DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Appl and appa

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_571639.1	Gene:	appa / 58083	ZFINID:	ZDB-GENE-000616-13	Length:	738	Species:	Danio rerio

Alignment Length:	911	Identity:	227/911 - (24%)
Similarity:	369/911 - (40%)	Gaps:	216/911 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRD 73
            :||.::...||:............|||||:.|  |::.....: :.|:|..|.|   ...:|:.:
Zfish     8 ILLMAVASTLAVEVPSDSGTGLLAEPQIAMFC--GKLNMHINI-QSGKWEPDPS---GSKSCIGN 66

  Fly    74 KMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDAL 137
            |..:|.||::.||...|||:||::....|..||::   :..:|:.....:.|:||| |.|.||||
Zfish    67 KEGILQYCQEVYPELQITNVVEANQPVSIWDWCKK---SRKQCRSHMHIVVPYRCLVGEFVSDAL 128

  Fly   138 LVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFK 202
            |||:.|.|.|......|...:.|:.....:|.:|.|.:..:.|||||||..|.||||||||
Zfish   129 LVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCGIDRFRGVEFVCCP---- 189

  Fly   203 TDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSN------DSNYSKDANEDDLDDEDDLMGDDE 261
                            |.....::...: :||||:      :::|::::...|...|..::.|||
Zfish   190 ----------------ADAGKESESAAV-EEDDSDVWWGGAEADYTENSMTRDAAAEPAVLEDDE 237

  Fly   262 EDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQS 326
            :    |||                          |.|..::||. :.|....|.|.|.|.:  ||
Zfish   238 D----ADE--------------------------EEDEDQDGDG-DRDEKIEEEEEEEERT--QS 269

  Fly   327 GGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLS--------ASAAAFVAANSGNSG- 382
            ..|   :|.|.:::.:.:......|.....:|:......||        ...|.|:....|.:.
Zfish   270 TSA---ALTSTTTTTTESVEEVVREVCFASAETGPCRAMLSRWYYVREERRCAPFIYGGCGGNRN 331

  Fly   383 ------------TGAGAPPSTAQPTS-DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDW 434
                        :|....||::.|.: |.|........||..:..:::.||..|||::::||::|
Zfish   332 NFESEEYCLSVCSGVLPTPSSSPPDAVDRYLETPADENEHAHFLQAKESLETKHRERMSQVMREW 396

  Fly   435 SDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKRE 499
            .:.|.:.:.:...|.||       :...||..|:|||:|..:|:.||...|..||.|.:|.|:|.
Zfish   397 EEAERQAKSLPRNDKKA-------VIQHFQEKVEALEQESASERQQLVETHMARVEALLNDRRRL 454

  Fly   500 AMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLE 564
            |:..|..||...||...||...|:|.:||..|||.|.|.|:.| :....|   :.||..||:.|.
Zfish   455 ALESYLSALQADPPRPRHVFSLLKKYVRAEQKDRQHTLKHFEH-VRMVDP---KKAAQIRPQVLT 515

  Fly   565 RLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVE 629
            .|..|:..:|||:.:|.:.|.::                 |||
Zfish   516 HLRVIEERMNQSLGLLYKVPGVA-----------------DDI---------------------- 541

  Fly   630 IERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQA 694
                   ::::.|.:::::|                        :.:|:|..||    .:..|..
Zfish   542 -------QDQVELLQREQQE------------------------MSAQLANLQS----DARVSYG 571

  Fly   695 QQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEATVSTKVQTV--LPTVDDDAV 757
            .......|..|.||.|           .|.|:....:....:.:.....:|:.|  .|..|.|..
Zfish   572 NDALMPDSTAGLELLP-----------AEDTQGFGFIHPESFNQPNTHNQVEPVDARPVPDLDLA 625

  Fly   758 QRAVEDVAA-AVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIA 821
            .|.|..:.. .:.....|.:.:|   .::.|::..|     ||:...:.|   .....|...|:.
Zfish   626 TRPVSGLKPDDIPELRMEAEERH---SEVYHQKLVF-----FAEDVSSNK---GAIIGLMVGGVV 679

  Fly   822 LMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYF 886
            :...:.:.:.:.:.:...|.| .|.||||..          :..||:.:..||.|||||||||:|
Zfish   680 IATIIVITLVMLRKKQYTSIH-HGIIEVDAA----------VTPEERHLSKMQQNGYENPTYKFF 733

  Fly   887 E 887
            |
Zfish   734 E 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	62/172 (36%)
		APP_N	33..141	CDD:280358	39/108 (36%)
		APP_Cu_bd	143..198	CDD:289676	22/54 (41%)
		APP_E2	387..580	CDD:289677	66/193 (34%)
		GBP_C	<629..682	CDD:303769	4/52 (8%)
		APP_amyloid	834..887	CDD:287486	20/52 (38%)
appa	NP_571639.1	A4_EXTRA	28..189	CDD:128326	62/169 (37%)
		APP_N	32..132	CDD:280358	39/108 (36%)
		APP_Cu_bd	134..189	CDD:289676	22/54 (41%)
		Kunitz_BPTI	293..343	CDD:278443	6/49 (12%)
		APP_E2	349..531	CDD:289677	66/192 (34%)
		Beta-APP	643..681	CDD:281491	9/48 (19%)
		APP_amyloid	684..734	CDD:287486	20/60 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589117
Domainoid	1	1.000	113	1.000	Domainoid score	I6081
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3103
OMA	1	1.010	-	-		QHG50020
OrthoDB	1	1.010	-	-		D405630at33208
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		otm25078
orthoMCL	1	0.900	-	-		OOG6_104222
Panther	1	1.100	-	-	O	PTHR23103
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000