DRSC/TRiP Functional Genomics Resources

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Protein Alignment Appl and col6a4a

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:XP_017207020.1 Gene:col6a4a / 564005 ZFINID:ZDB-GENE-041111-303 Length:2568 Species:Danio rerio


Alignment Length:630 Identity:118/630 - (18%)
Similarity:200/630 - (31%) Gaps:156/630 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   275 GSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSG----GAKVVSLK 335
            |||  ||.|  ..|:...:.:....|:.||..|:...||.....:.......|    |.|  ..|
Zfish  1792 GSP--GSPG--RPGTKGSLGSRGQKGQPGDPGEKGSLGSAGSRGLPGKDGNDGYGYPGLK--GQK 1850

  Fly   336 SDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAAN-----SGNSGTGAGA----PPST 391
            .||..|                    ..|.|... ..|...|     .|:.|.|..|    ||  
Zfish  1851 GDSGFP--------------------GYPGLQGE-LGFKGTNGGVGPKGSRGRGGNAGRTGPP-- 1892

  Fly   392 AQPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQD----MRLADPKAA 452
            ..|.|.....|..|.....:.::|..:|....|:. ....||.........|    |.:::....
Zfish  1893 GDPGSGGMTGHRGPKGPRGARQMSDCQLISYVRDN-CMCCKDNIKCPAYPTDLVIGMDMSEDVTP 1956

  Fly   453 QSFKQRMTA---RFQTSVQALEEE--GNAEKHQLAAMHQQRVLAHIN--QRKREAMTCYTQALTE 510
            |.| :||.:   |...:::..|..  ..|....::.....:.|...|  .||::.:........|
Zfish  1957 QGF-ERMRSVVLRLLDNMKIAESSCPTGARVALVSYSSFTKYLIRFNDYHRKKQLIDAVNNIALE 2020

  Fly   511 QPPNAHHVEKCL----QKLLRALHK--------------------DRAHALAHYRHLLNSGGPGG 551
            :..|..::...:    :.:|:.:.|                    ....|:..|:.|...     
Zfish  2021 RTSNRRNIGAAMRFVGRNVLKRVRKGILMRKVAIFLTAGESQDSISLTTAILEYKALNIK----- 2080

  Fly   552 LEAAASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMN--------------------- 595
            |...|......:.|..:.|.:.:..:|:|.|..:.:|.::::.:                     
Zfish  2081 LGVIALRNVPAIRRAFEADESQSFILTVLGRVQDQNATLSKIQSCVICYDPCRPARECEGTNLPS 2145

  Fly   596 -------DYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKE---- 649
                   |:::.:.....|........:|...|:||:..|..:...|::: .|:|..|:..    
Zfish  2146 APQELDMDFVMVVDGSRSILADEFKGVKEVLGGVLDQIVVSSQPTRADRQ-ARVALYQQTSTYSD 2209

  Fly   650 -QRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAA 713
             |.|.|...|||...|       :::|:.:.::..|...|.......:...:|..       :|.
Zfish  2210 PQPAHEIFSLREFSDR-------NLMKTSIIQKLKQTGGSHELGSTLEFAFKKCF-------NAV 2260

  Fly   714 LVTAANPNL------ETTKSEKDLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQE 772
            ..:..|..|      ||...||...|:....|..|..|...| ||.|......||::|       
Zfish  2261 PESRKNKMLLAIIGEETALQEKKRLDSFSRLAKCSGIVLFTL-TVGDSIASSQVEELA------- 2317

  Fly   773 AEPQVQHFMTHDLGHRESSFSLRREFAQH-----AHAAKEGRNVY 812
            :.|..||.:  .|||.:..   .:|:.|.     .|...:..|.|
Zfish  2318 SYPLEQHII--HLGHLKHG---EQEYTQRFMRTFFHILSKNMNTY 2357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326
APP_N 33..141 CDD:280358
APP_Cu_bd 143..198 CDD:289676
APP_E2 387..580 CDD:289677 37/231 (16%)
GBP_C <629..682 CDD:303769 12/57 (21%)
APP_amyloid 834..887 CDD:287486
col6a4aXP_017207020.1 vWA_collagen 35..198 CDD:238749
VWA 230..>362 CDD:278519
VWA 416..588 CDD:278519
VWA 622..784 CDD:278519
VWA 807..975 CDD:278519
VWA 995..1164 CDD:278519
vWA_collagen 1184..1351 CDD:238749
VWA <1451..1548 CDD:214621
Collagen 1584..1676 CDD:189968
Collagen 1659..1739 CDD:189968
Collagen 1786..1840 CDD:189968 13/51 (25%)
Collagen 1842..1912 CDD:189968 20/94 (21%)
VWA 1943..2107 CDD:278519 24/169 (14%)
VWA 2153..2325 CDD:278519 42/194 (22%)
Kunitz_BPTI 2438..2490 CDD:278443
Kunitz_BPTI 2510..2561 CDD:278443
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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