Protein Alignment Appl and Aplp1

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: XP_038944236.1
• Gene: Aplp1 / 502317
• RGDID: 69257
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 894
• Identity: 199/894 - (22%)
• Similarity: 313/894 - (35%)
• Gaps: 285/894 - (31%)

  Fly     9 LLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRD 73
            ||||:...|..:......||......|:|.||  |::...:.| ..|||..|..:..   .||.|
  Rat    29 LLLRAQLAVGNLAGGSPSAAEAPGSAQVAGLC--GRLTLHRDL-RTGRWEPDPQRSR---RCLLD 87

  Fly    74 KMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDAL 137
            ...:|:||::.||...|..:.:::....:..||  |...:.:|...|..:.||.|| |.|.|:||
  Rat    88 PQRVLEYCRQMYPELHIARVEQAAQAIPMERWC--GGTRSGRCAHPHHEVVPFHCLPGEFVSEAL 150

  Fly   138 LVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFK 202
            ||||||.|.|.....:|....|.:|....||..:|:.:....||||||...|.|||:||||.
  Rat   151 LVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPP--- 212

  Fly   203 TDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVA 267
                       |..|
  Rat   213 -----------PATP-------------------------------------------------- 216

  Fly   268 DEAATAGGSPNTGS--SGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAK 330
            :.:..|.|.|:|.|  .|....|..|:...|.......|.:.|.....|.|.|.|
  Rat   217 NPSGMAVGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEE---------- 271

  Fly   331 VVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPT 395
                       ..||  |.....||....||.||                            :||
  Rat   272 -----------ERAP--PPSSHTPVMVSRVTPTP----------------------------RPT 295

  Fly   396 S--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQR 458
            .  |.||.......||:.:..::..|||....::..||::|:..:.:.:::..||       :|.
  Rat   296 DGVDVYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKAD-------RQA 353

  Fly   459 MTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQ 523
            :...||:.:|.|||:.:.|:.:|...|..||:|.||.::|.|:..:..||...||.|..|...|:
  Rat   354 LNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALR 418

  Fly   524 KLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYP---- 584
            :.|||..|::.|.|.||:|:. :..|   |.|...|.:....|..:...:|||:.:|.:.|
  Rat   419 RYLRAEQKEQRHTLRHYQHVA-AVDP---EKAQQMRFQVQTHLQVVQERMNQSLGLLDQNPHLAQ 479

  Fly   585 ELSAKIAQLMN-DYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRK 648
            ||..:|.:|:: :::.....:..:||||   ||:
  Rat   480 ELRPQIQELLHAEHLGPSELEASVPGSS---SED------------------------------- 510

  Fly   649 EQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAA 713
                                      |..:...:|:...:..........||.|..|:|
  Rat   511 --------------------------KGSLQPPESKDADAPVTLPKGSTDQESSSSGRE------ 543

  Fly   714 LVTAANPNLETTKSEKDLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQ 778
                            .|:..|..|..|:.......|....| :||  :::|.|
  Rat   544 ----------------KLTPLEQYEQKVNASAPRGFPFHSSD-IQR--DELAPA----------- 578

  Fly   779 HFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAA-----VFVGVAVAKWRTS 838
                        ...:.||                  :.:|:.:|.|     :.:.:.:.:.:..
  Rat   579 ------------GTGVSRE------------------ALSGLLIMGAGGGSLIVLSLLLLRKKKP 613

  Fly   839 RSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887
            ....:.|.:|||.:          :..||:.:..:|.:|||||||::.|
  Rat   614 YGTISHGVVEVDPM----------LTLEEQQLRELQRHGYENPTYRFLE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	61/172 (35%)
		APP_E2	388..580	CDD:463752	56/193 (29%)
		DDRGK	632..>682	CDD:370664	1/49 (2%)
		APP_amyloid	834..887	CDD:463129	14/52 (27%)
Aplp1	XP_038944236.1	A4_EXTRA	46..211	CDD:128326	61/172 (35%)
		APP_E2	289..471	CDD:463752	59/220 (27%)
		JMTM_Notch_APP	569..653	CDD:425406	25/138 (18%)