DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Appl and app

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_001005698.1 Gene:app / 448208 XenbaseID:XB-GENE-479154 Length:750 Species:Xenopus tropicalis


Alignment Length:922 Identity:237/922 - (25%)
Similarity:366/922 - (39%) Gaps:233/922 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VVLAIGTAQVQA-----ASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKM 75
            :|||.|...::.     |....|||||:.|  |::.....: :.|:|.||:| .|.|  |:..|.
 Frog     8 LVLAAGALALEVPADGNAGLLAEPQIAMFC--GKLNMHMNV-QNGKWETDVS-GTKG--CIGTKE 66

  Fly    76 DLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLV 139
            .:|.||:..||...|||:||::....|..||::|   ..:||.....:.|:||| |.|.||||||
 Frog    67 GILQYCQDVYPELQITNVVEANQPVTIQNWCKRG---RKQCKSRTHIVVPYRCLVGEFVSDALLV 128

  Fly   140 PEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTD 204
            |:.|.|.|......|...:.|:.....:|.|:.|.:..:.|||||||..|.||||||||      
 Frog   129 PDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCP------ 187

  Fly   205 EIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKD--------ANEDDLDDEDDLMGD-- 259
                                     ..||.:|.||..::|        |:.|.:|..||...:  
 Frog   188 -------------------------TADESESFDSADAEDDSDVWWGGADADYIDRSDDKAVEAQ 227

  Fly   260 -DEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASW 323
             :||:::|..|.                              ||.|:.|:|  |.|:|.|.|..:
 Frog   228 PEEEEEVVEVEE------------------------------EEADDDEDD--GDEAEEEPEEPY 260

  Fly   324 DQSGGAKVVSLKSDSSSPSSAPVAPAPEKA--PVKSESVTSTP-----------QLSASAAAFVA 375
            :::      :.::.|.:.::.....:.|:.  .|.||...:.|           ......|.|:.
 Frog   261 EEA------TERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIPRWYYDVTERKCAQFIY 319

  Fly   376 ANSGNSGT------------GAGAPPSTAQPTS---DPYFTHFDPHYEHQSYKVSQKRLEESHRE 425
            ...|.:..            |:...|:||..|.   |.|..:.:...||..:..:::|||..|||
 Frog   320 GGCGGNRNNFDSEDYCMAVCGSVTVPATAASTPDAVDKYLENPNDENEHDRFLKAKERLEGKHRE 384

  Fly   426 KVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVL 490
            |::.|||:|.:.|.:.:::..||.||       :...||..|::||:|...|:.||...|..||.
 Frog   385 KMSEVMKEWEEAERQAKNLPKADKKA-------VIQHFQEKVESLEQEAANERQQLVETHMARVE 442

  Fly   491 AHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAA 555
            |.:|.|:|.|:..|..||...||...||...|:|.:||..|||.|.|.|:.| :....|   :.|
 Frog   443 AMLNDRRRIALENYITALQADPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEH-VRMVDP---KKA 503

  Fly   556 ASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEA 620
            |..|.:.:..|..|:..:|||.::|.:.|    .:|:.:.|.:..|..|:.      ..|::..:
 Frog   504 AQIRSQVMTHLRVINERMNQSFSLLYKVP----AVAEEIQDEVEELFQKEQ------NYSDDMVS 558

  Fly   621 GILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQP 685
            .::..:|:.....                   |....|.|.|..:|...||    .:...:..||
 Frog   559 NMVSDHRISYGND-------------------ALMPSLTETKTTVELLPVD----GEFNVEDLQP 600

  Fly   686 TQS-STQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLS----DTEYGEATVSTKV 745
            ..| ...|.....:.|..........|..|.|.....|...|:| ::|    |:||.        
 Frog   601 WHSFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTE-EISEVKMDSEYR-------- 656

  Fly   746 QTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRN 810
                            .|.|..|.||:..     |...::|                    ..:.
 Frog   657 ----------------HDAAYEVHHQKLV-----FFAEEVG--------------------SNKG 680

  Fly   811 VYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQI 875
            ....|...|:.:...:.:.:.:.|.:...:.| .|.:|||..          :..||:.:..||.
 Frog   681 AIIGLMVGGVVIATVIVITLVMLKKKQYTTIH-HGVVEVDAA----------VTPEERHLTKMQQ 734

  Fly   876 NGYENPTYKYFE 887
            |||||||||:||
 Frog   735 NGYENPTYKFFE 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 68/177 (38%)
APP_N 33..141 CDD:280358 44/108 (41%)
APP_Cu_bd 143..198 CDD:289676 22/54 (41%)
APP_E2 387..580 CDD:289677 68/195 (35%)
GBP_C <629..682 CDD:303769 7/52 (13%)
APP_amyloid 834..887 CDD:287486 19/52 (37%)
appNP_001005698.1 A4_EXTRA 23..187 CDD:128326 68/172 (40%)
Kunitz_BPTI 292..339 CDD:333766 4/46 (9%)
APP_E2 346..528 CDD:372388 67/192 (35%)
Beta-APP 657..693 CDD:367525 9/60 (15%)
APP_amyloid 696..746 CDD:371108 19/60 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 109 1.000 Domainoid score I6271
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I3201
OMA 1 1.010 - - QHG50020
OrthoDB 1 1.010 - - D405630at33208
OrthoFinder 1 1.000 - - FOG0001588
OrthoInspector 1 1.000 - - otm48427
Panther 1 1.100 - - O PTHR23103
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2378
SonicParanoid 1 1.000 - - X996
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.200

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