Protein Alignment Appl and app

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_001005698.1
• Gene: app / 448208
• XenbaseID: XB-GENE-479154
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 922
• Identity: 237/922 - (25%)
• Similarity: 366/922 - (39%)
• Gaps: 233/922 - (25%)

  Fly    16 VVLAIGTAQVQA-----ASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKM 75
            :|||.|...::.     |....|||||:.|  |::.....: :.|:|.||:| .|.|  |:..|.
 Frog     8 LVLAAGALALEVPADGNAGLLAEPQIAMFC--GKLNMHMNV-QNGKWETDVS-GTKG--CIGTKE 66

  Fly    76 DLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLV 139
            .:|.||:..||...|||:||::....|..||::|   ..:||.....:.|:||| |.|.||||||
 Frog    67 GILQYCQDVYPELQITNVVEANQPVTIQNWCKRG---RKQCKSRTHIVVPYRCLVGEFVSDALLV 128

  Fly   140 PEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTD 204
            |:.|.|.|......|...:.|:.....:|.|:.|.:..:.|||||||..|.||||||||
 Frog   129 PDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCP------ 187

  Fly   205 EIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKD--------ANEDDLDDEDDLMGD-- 259
                                     ..||.:|.||..::|        |:.|.:|..||...:
 Frog   188 -------------------------TADESESFDSADAEDDSDVWWGGADADYIDRSDDKAVEAQ 227

  Fly   260 -DEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASW 323
             :||:::|..|.                              ||.|:.|:|  |.|:|.|.|..:
 Frog   228 PEEEEEVVEVEE------------------------------EEADDDEDD--GDEAEEEPEEPY 260

  Fly   324 DQSGGAKVVSLKSDSSSPSSAPVAPAPEKA--PVKSESVTSTP-----------QLSASAAAFVA 375
            :::      :.::.|.:.::.....:.|:.  .|.||...:.|           ......|.|:.
 Frog   261 EEA------TERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIPRWYYDVTERKCAQFIY 319

  Fly   376 ANSGNSGT------------GAGAPPSTAQPTS---DPYFTHFDPHYEHQSYKVSQKRLEESHRE 425
            ...|.:..            |:...|:||..|.   |.|..:.:...||..:..:::|||..|||
 Frog   320 GGCGGNRNNFDSEDYCMAVCGSVTVPATAASTPDAVDKYLENPNDENEHDRFLKAKERLEGKHRE 384

  Fly   426 KVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVL 490
            |::.|||:|.:.|.:.:::..||.||       :...||..|::||:|...|:.||...|..||.
 Frog   385 KMSEVMKEWEEAERQAKNLPKADKKA-------VIQHFQEKVESLEQEAANERQQLVETHMARVE 442

  Fly   491 AHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAA 555
            |.:|.|:|.|:..|..||...||...||...|:|.:||..|||.|.|.|:.| :....|   :.|
 Frog   443 AMLNDRRRIALENYITALQADPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEH-VRMVDP---KKA 503

  Fly   556 ASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEA 620
            |..|.:.:..|..|:..:|||.::|.:.|    .:|:.:.|.:..|..|:.      ..|::..:
 Frog   504 AQIRSQVMTHLRVINERMNQSFSLLYKVP----AVAEEIQDEVEELFQKEQ------NYSDDMVS 558

  Fly   621 GILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQP 685
            .::..:|:.....                   |....|.|.|..:|...||    .:...:..||
 Frog   559 NMVSDHRISYGND-------------------ALMPSLTETKTTVELLPVD----GEFNVEDLQP 600

  Fly   686 TQS-STQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLS----DTEYGEATVSTKV 745
            ..| ...|.....:.|..........|..|.|.....|...|:| ::|    |:||.
 Frog   601 WHSFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTE-EISEVKMDSEYR-------- 656

  Fly   746 QTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRN 810
                            .|.|..|.||:..     |...::|                    ..:.
 Frog   657 ----------------HDAAYEVHHQKLV-----FFAEEVG--------------------SNKG 680

  Fly   811 VYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQI 875
            ....|...|:.:...:.:.:.:.|.:...:.| .|.:|||..          :..||:.:..||.
 Frog   681 AIIGLMVGGVVIATVIVITLVMLKKKQYTTIH-HGVVEVDAA----------VTPEERHLTKMQQ 734

  Fly   876 NGYENPTYKYFE 887
            |||||||||:||
 Frog   735 NGYENPTYKFFE 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	68/177 (38%)
		APP_E2	388..580	CDD:463752	68/194 (35%)
		DDRGK	632..>682	CDD:370664	7/49 (14%)
		APP_amyloid	834..887	CDD:463129	19/52 (37%)
app	NP_001005698.1	A4_EXTRA	23..187	CDD:128326	68/172 (40%)
		Kunitz_ABPP-like	292..339	CDD:438650	4/46 (9%)
		APP_E2	347..528	CDD:463752	67/191 (35%)
		JMTM_Notch_APP	673..747	CDD:425406	24/105 (23%)