Protein Alignment Appl and aplp1

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: XP_001342921.4
• Gene: aplp1 / 404233
• ZFINID: ZDB-GENE-040319-1
• Length: 723
• Species: Danio rerio
• Alignment Length: 891
• Identity: 211/891 - (23%)
• Similarity: 357/891 - (40%)
• Gaps: 225/891 - (25%)

  Fly    20 IGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKA 84
            :|..||.      :||||:.|....::..   :|.|:|..|...:   ..|......:|.||::.
Zfish    32 VGGPQVA------DPQIAMFCGRQLLHMN---TESGQWEPDPQGR---QGCFTQPSKILSYCQEM 84

  Fly    85 YPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLVPEGCLFDHI 148
            ||...|:::.|:|....|.|||::|   ...|:.....:.|:||| |.:.|:|||||:.|.|.|.
Zfish    85 YPGLQISHVEEASSPATIQGWCKKG---WGHCQTRTFIVVPYRCLVGEYVSEALLVPDRCRFLHQ 146

  Fly   149 HNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCP---------KHFKTD 204
            .....|..:|.|:.....||....:::.|:.|||||| ..|.|||:||||         :....|
Zfish   147 EQMDSCESYVYWHNIAKEACTADSLELHSYGMLLPCG-DRFRGVEYVCCPGRTGSSGRGETETAD 210

  Fly   205 EIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADE 269
            .:..:.|.|       ::.|.|:.:.:.:......:.|.   |.|: :|||:  ::|||::|.:|
Zfish   211 IVQGETTPL-------VSMAGDKTITSVKTTPPTPSPSP---ETDI-EEDDM--EEEEDEVVEEE 262

  Fly   270 AATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSL 334
            |                              ||.:..||:| .:|:.||||.: ::...|..|..
Zfish   263 A------------------------------EEEEEEEEEG-NNEAAAEVEEA-EEEETATTVKY 295

  Fly   335 KSDSSSPSSAPVAPAP-------EKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTA 392
            :.:...|..:.:....       :| .:::...::.||                 |.....| |.
Zfish   296 QEEYEYPIDSHLQGQDYMDNFYYDK-NLQTAKASTQPQ-----------------TRMDNMP-TP 341

  Fly   393 QPTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSF 455
            :||.  |.||.......||.::..::..|||...:::..:||:|::.:.:.:::    ||   |.
Zfish   342 RPTDGVDVYFEMPGDDSEHANFLRAKMDLEERRMKRINEIMKEWAEADNQSKNL----PK---SD 399

  Fly   456 KQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEK 520
            :|.:...||:.:|.|||:...|:.:|...|..||:|.:|..:|.|:..|..|:...||....|.:
Zfish   400 RQALNEHFQSVLQTLEEQVAGERQRLVETHLARVVATLNNNRRLALESYLSAVQSDPPQPDRVLQ 464

  Fly   521 CLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPE 585
            .|::.:.|..|||.|.|.||:| :.|..|   :.|...:.:....|..|:..:|||:.:|.:.|.
Zfish   465 ALKRYMAAEQKDRRHTLRHYQH-IESADP---QKAEQMKFQVYTHLHVIEERMNQSLALLYKVPG 525

  Fly   586 LSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQ 650
            |:.|:...:.:.:                  ..|.|.:.:.......:....|.|..||.:  |:
Zfish   526 LAEKLHDEIQELV------------------RTERGDISELMTTSFSETRTTEELLPAESE--EE 570

  Fly   651 RAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALV 715
            |..|.|:.|..:.|....::|           .||......|     ..|......|.||
Zfish   571 RDDEEEEDRAFQNRPYPPRID-----------PQPVDKKVSS-----VDEYDYTTSERGP----- 614

  Fly   716 TAANPNLETTKSEKDLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHF 780
                             ..|| |..::|.|:..........:||           .|.:|.|  .
Zfish   615 -----------------TYEY-EEKINTSVELKQVVYKSPGIQR-----------DELQPDV--L 648

  Fly   781 MTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMA-AVFVGVAVAKWRTSRSPH-- 842
            .|.:.|                             :..|:.::| |:.:.:.::.....|.|:
Zfish   649 ETFNRG-----------------------------AMVGLLVVAVAIAMVMVISLLLVRRKPYGT 684

  Fly   843 -AQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887
             :.|.:|||.:          :..||:.:..||.:||||||||:||
Zfish   685 ISHGIVEVDPM----------LTPEERQLNKMQNHGYENPTYKFFE 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	56/172 (33%)
		APP_E2	388..580	CDD:463752	57/193 (30%)
		DDRGK	632..>682	CDD:370664	11/49 (22%)
		APP_amyloid	834..887	CDD:463129	18/55 (33%)
aplp1	XP_001342921.4	A4_EXTRA	37..195	CDD:128326	57/173 (33%)
		APP_E2	339..520	CDD:463752	57/192 (30%)
		JMTM_APLP1	637..721	CDD:411991	30/136 (22%)