DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Appl and APLP2

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001633.1	Gene:	APLP2 / 334	HGNCID:	598	Length:	763	Species:	Homo sapiens

Alignment Length:	900	Identity:	227/900 - (25%)
Similarity:	374/900 - (41%)	Gaps:	234/900 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESS 97
            |||||:.|  |::.....: :.|:|..|   .|...:|...|.::|.||::.||...|||::|::
Human    49 EPQIAMFC--GKLNMHVNI-QTGKWEPD---PTGTKSCFETKEEVLQYCQEMYPELQITNVMEAN 107

  Fly    98 HYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWN 161
            ....|..|||:   :..:||.  |::.||:|| |.|.||.|||||.|.|.|......|.....|:
Human   108 QRVSIDNWCRR---DKKQCKS--RFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 167

  Fly   162 QTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSAND 226
            .....||..:||.:.|:.||||||:..|.|.|:||||           :|.: :...::.....|
Human   168 TVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCP-----------QTKI-IGSVSKEEEEED 220

  Fly   227 ELVMNDEDDSNDSNYSKD--ANEDDLDD-EDDLMGDDEEDDMVADEAATAGGSPNTGSSGDSNSG 288
            |....:||:..|.:..|.  ..|.||:| .:..:.:|:||:...:|.
Human   221 EEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEV------------------ 267

  Fly   289 SLDDINAEYDSGEEGDNYEEDGA------GSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPVA 347
             ::|.:..||: .:||:|.|:..      |:.|:.|:      :...|.|..:...:.|..| |.
Human   268 -VEDRDYYYDT-FKGDDYNEENPTEPGSDGTMSDKEI------THDVKAVCSQEAMTGPCRA-VM 323

  Fly   348 PAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTG------------AGAPPSTAQPTS--DP 398
            |.......|.:.|           .|:....|.:...            |..|| |..||:  |.
Human   324 PRWYFDLSKGKCV-----------RFIYGGCGGNRNNFESEDYCMAVCKAMIPP-TPLPTNDVDV 376

  Fly   399 YFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARF 463
            ||.......||..::.::::||..||.::.||.|:|.:.|.:.:::    |||.   :|.:...|
Human   377 YFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNL----PKAE---RQTLIQHF 434

  Fly   464 QTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRA 528
            |..|:|||:|..:||.||...|..||.|.:|.|:|.|:..|..||...||..|.:.:.|::.:||
Human   435 QAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRA 499

  Fly   529 LHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQL 593
            .:|||.|.:.||:|:| :..|   |.||..:.:.:..|..|:...|||:::|.:.|.::.:|.:.
Human   500 ENKDRLHTIRHYQHVL-AVDP---EKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEE 560

  Fly   594 MNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKL 658
            :::                         :|.:.|.::::..|.
Human   561 IDE-------------------------LLQEQRADMDQFTAS---------------------- 578

  Fly   659 REEKLRLEAKKVDDMLKSQVAEQ----------QSQPTQSSTQSQAQQQQQEKSLPGKELGPDAA 713
                  :....||..:.|:.:|:          .:.|....||.:.....::.|..|::   |..
Human   579 ------ISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQ---DGG 634

  Fly   714 LVTAANPNLETTKSEKDLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQ 778
            |:.|.                   |..:::|.:     ||::.|.....||...:.:.|....::
Human   635 LIGAE-------------------EKVINSKNK-----VDENMVIDETLDVKEMIFNAERVGGLE 675

  Fly   779 HFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVA---------- 833
            .       .|||...||.:|                 |.:..||:..:.:.||:|
Human   676 E-------ERESVGPLREDF-----------------SLSSSALIGLLVIAVAIATVIVISLVML 716

  Fly   834 -KWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887
             |.:.....|  |.:|||.:          :..||:.:..||.:|||||||||.|
Human   717 RKRQYGTISH--GIVEVDPM----------LTPEERHLNKMQNHGYENPTYKYLE 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	63/165 (38%)
		APP_N	33..141	CDD:280358	40/108 (37%)
		APP_Cu_bd	143..198	CDD:289676	21/54 (39%)
		APP_E2	387..580	CDD:289677	68/194 (35%)
		GBP_C	<629..682	CDD:303769	5/62 (8%)
		APP_amyloid	834..887	CDD:287486	19/52 (37%)
APLP2	NP_001633.1	A4_EXTRA	42..204	CDD:128326	63/165 (38%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	46..139		34/100 (34%)
		APP_N	49..147	CDD:280358	40/108 (37%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	147..205		24/68 (35%)
		APP_Cu_bd	149..204	CDD:289676	21/54 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..299		22/107 (21%)
		Kunitz_BPTI	309..361	CDD:278443	9/63 (14%)
		APP_E2	365..547	CDD:289677	68/193 (35%)
		APP_amyloid	709..759	CDD:287486	19/61 (31%)
		Interaction with DAB2. /evidence=ECO:0000250	749..763		9/10 (90%)
		NPXY motif	750..755		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153900
Domainoid	1	1.000	108	1.000	Domainoid score	I6423
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3526
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50020
OrthoDB	1	1.010	-	-		D405630at33208
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		otm41214
orthoMCL	1	0.900	-	-		OOG6_104222
Panther	1	1.100	-	-	O	PTHR23103
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2378
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800