Protein Alignment Appl and Spint1

DIOPT Version :9

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_001004265.2
• Gene: Spint1 / 311331
• RGDID: 1303138
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 396
• Identity: 82/396 - (20%)
• Similarity: 128/396 - (32%)
• Gaps: 139/396 - (35%)

  Fly    53 EEGRWVTDLSKKTTGPTCLRDKMDLL----------DYCKKAYPNRDITNIVESSHYQKIGGWCR 107
            :||.::..|::  |....|.:.::|.          |||..:|               |:|
  Rat   208 KEGTYLFQLTR--TDSDQLEETVNLTITVLTAEQTEDYCLASY---------------KVG---- 251

  Fly   108 QGALNAAKCKGSH-RW--------IKPFR---CLGPFQSDALLVPEGCLFDHIHNASRCWPFVRW 160
                   :|:||. ||        .|.|.   |||  ..:..|..|.|:.
  Rat   252 -------RCRGSFPRWYYDPKEQICKSFTFGGCLG--NKNNYLREEECML--------------- 292

  Fly   161 NQTGAAACQE-RGMQMRSFAMLLPCGISVFSGVEFV----CCPKHFKTDEIHVKKTDLPVMPAAQ 220
                  ||:: :|:..:....:  |..|..| .:|.    ||...|      ::..|.|..|
  Rat   293 ------ACKDVKGISPKRHHPV--CTGSCHS-TQFQCSNGCCIDGF------LECDDTPDCP--- 339

  Fly   221 INSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDM--VADEAATAGGSPNTGSSG 283
                      :..|::....||.              |.||...:  ::|:...| ..|:||.
  Rat   340 ----------DGSDEATCEKYSS--------------GFDELQSIHFLSDKGYCA-ELPDTGF-- 377

  Fly   284 DSNSGSLDDINAEYDS--GEEGDNYEEDGA-GSESEAEVEASWDQS--GGAK--VVSLKSDSSSP 341
                 ..::|...|.:  .|....:...|. |:::..|.|....:|  |.:|  |..|:.:||.|
  Rat   378 -----CKENIPRWYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVP 437

  Fly   342 SSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTSDPYFTHFDPH 406
            |:..|    |.|.....:|.....|:.....|......|..:....||.|  |.|....|..|.
  Rat   438 SAGSV----EVAIAVLLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPT--PASSTVSTTEDT- 495

  Fly   407 YEHQSY 412
             ||..|
  Rat   496 -EHLVY 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	33/171 (19%)
		APP_N	33..141	CDD:280358	23/109 (21%)
		APP_Cu_bd	143..198	CDD:289676	9/59 (15%)
		APP_E2	387..580	CDD:289677	10/26 (38%)
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
Spint1	NP_001004265.2	MANEC	44..133	CDD:284837
		Kunitz_BPTI	243..295	CDD:278443	19/100 (19%)
		LDLa	313..344	CDD:197566	8/50 (16%)
		Kunitz_BPTI	368..420	CDD:278443	12/59 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900