DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Appl and Ambp

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	XP_008761981.1	Gene:	Ambp / 25377	RGDID:	2102	Length:	361	Species:	Rattus norvegicus

Alignment Length:	255	Identity:	50/255 - (19%)
Similarity:	81/255 - (31%)	Gaps:	83/255 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CAALRR--NLLLRSLWVVLAIGT-AQVQAASPRWEPQIAVLC-EAGQIYQP-----QYLSEEGRW 57
            |..|||  |.:..|..|:....| |::...|.:|...:   | |...:||.     ::|..:.:|
  Rat    52 CPWLRRIKNKMSVSTLVLQEGATEAEISVTSTQWRKGV---CEEISGVYQKTDIDGKFLYHKSKW 113

  Fly    58 VTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRW 122
                                         |..:.:.|..::|.:.       |:...| |.|||.
  Rat   114 -----------------------------NATLESYVVHTNYDEY-------AIFLTK-KFSHRH 141

  Fly   123 IKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAML--LPCG 185
                   ||..:..|...|..|.|.:                   .||    .|..|:.  :|..
  Rat   142 -------GPTITAKLYGREPQLRDSL-------------------LQE----FREVALSVGIPEN 176

  Fly   186 ISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMN--DEDDSNDSNYSK 243
            ..||......|.|...:.:.....:....|:|.....|.::.|:..  .::||...|||:
  Rat   177 SIVFMADRGECVPGDREVESTSFARARRAVLPQENEGSGSEPLITGTLKKEDSCQLNYSE 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	31/179 (17%)
		APP_N	33..141	CDD:280358	18/113 (16%)
		APP_Cu_bd	143..198	CDD:289676	10/56 (18%)
		APP_E2	387..580	CDD:289677
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
Ambp	XP_008761981.1	Lipocalin	41..185	CDD:278490	39/202 (19%)
		Kunitz_BPTI	230..281	CDD:278443	3/7 (43%)
		Kunitz_BPTI	285..337	CDD:278443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900