DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Appl and Y49G5A.1

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_504413.1	Gene:	Y49G5A.1 / 190090	WormBaseID:	WBGene00021731	Length:	182	Species:	Caenorhabditis elegans

Alignment Length:	192	Identity:	40/192 - (20%)
Similarity:	56/192 - (29%)	Gaps:	70/192 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLR 72
            ||||..|..:|.:.                   |.....||     |.:...|:.|    ..|..
Worm     2 NLLLTFLATILCVS-------------------ELVSTLQP-----ECKLPLDMGK----TPCKN 38

  Fly    73 DKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDAL 137
            .|.::      .|.....:||..:..|...|| .:......::|:        |.|.|..||
Worm    39 GKKEI------RYHFDQKSNIPLAFEYSGCGG-NKNNFKTESECR--------FTCTGYDQS--- 85

  Fly   138 LVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPK 199
                ||       |:...|.   |.......:|.|          |.||..:|....:||.|
Worm    86 ----GC-------AAGSKPI---NDKNCQTDEECG----------PKGICRYSNHINICCDK 123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	32/171 (19%)
		APP_N	33..141	CDD:280358	20/107 (19%)
		APP_Cu_bd	143..198	CDD:289676	11/54 (20%)
		APP_E2	387..580	CDD:289677
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
Y49G5A.1	NP_504413.1	KU	25..79	CDD:197529	12/72 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900