DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Appl and apl-1

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_508870.3 Gene:apl-1 / 180783 WormBaseID:WBGene00000149 Length:686 Species:Caenorhabditis elegans


Alignment Length:940 Identity:239/940 - (25%)
Similarity:374/940 - (39%) Gaps:320/940 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LLRSLWVVLAIGTAQVQ---AASPRWE---PQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGP 68
            |:..|.:.:.:.|...:   |.|.|.|   |.:|..|.    |:.||::|||.|.||..:..   
 Worm     6 LMIGLLIPILVATVYAEGSPAGSKRHEKFIPMVAFSCG----YRNQYMTEEGSWKTDDERYA--- 63

  Fly    69 TCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPF 132
            ||...|:|:|.||:||||:.:||||||.||...|..|||:   ..:.||.:|. ::|:.|: |.|
 Worm    64 TCFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCRE---EGSPCKWTHS-VRPYHCIDGEF 124

  Fly   133 QSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQ------ERGMQMRSFAMLLPCGISVFSG 191
            .|:||.||..|.|.|:::..:|..:..|.......|:      .:.|.:||||:|.||.:.:|:|
 Worm   125 HSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPCALDMFTG 189

  Fly   192 VEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDL 256
            |||||||                                ||:.:..|...:|       :|||| 
 Worm   190 VEFVCCP--------------------------------NDQTNKTDVQKTK-------EDEDD- 214

  Fly   257 MGDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEA 321
              ||:|||...|                             |..||.|                 
 Worm   215 --DDDEDDAYED-----------------------------DYSEESD----------------- 231

  Fly   322 SWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAG 386
                         :.|...|||                                           
 Worm   232 -------------EKDEEEPSS------------------------------------------- 240

  Fly   387 APPSTAQPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKA 451
                     .||||...:...||..:|.::.|::|.||:||.:|||:|.|||.:|.:.:..|||.
 Worm   241 ---------QDPYFKIANWTNEHDDFKKAEMRMDEKHRKKVDKVMKEWGDLETRYNEQKAKDPKG 296

  Fly   452 AQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTE--QPPN 514
            |:.||.:|.||||.:|.:||||....:.::.|:|::||.|.:|::||:|...|.|||..  ..||
 Worm   297 AEKFKSQMNARFQKTVSSLEEEHKRMRKEIEAVHEERVQAMLNEKKRDATHDYRQALATHVNKPN 361

  Fly   515 AHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTM 579
            .|.|.:.|:..:||..|||.|.|..|||||.:..    :.||:.:|..:.||..||..:|.::.|
 Worm   362 KHSVLQSLKAYIRAEEKDRMHTLNRYRHLLKADS----KEAAAYKPTVIHRLRYIDLRINGTLAM 422

  Fly   580 LKRYPEL--------------------------SAKIAQLMNDYILALRSKDDI----------- 607
            |:.:|:|                          .:::..:::|...:..:|.|:           
 Worm   423 LRDFPDLEKYVRPIAVTYWKDYRDEVSPDISVEDSELTPIIHDDEFSKNAKLDVKAPTTTAKPVK 487

  Fly   608 --------PGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLR 664
                    |..:....|||:....|:...::::....|:::::.:.:.||.:....|:.:..||.
 Worm   488 ETDNAKVLPTEASDSEEEADEYYEDEDDEQVKKTPDMKKKVKVVDIKPKEIKVTIEEEKKAPKLV 552

  Fly   665 LEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEK 729
            ..:.:.||       |...:.:.|||.|:: .:.::|::  |||..|                  
 Worm   553 ETSVQTDD-------EDDDEDSSSSTSSES-DEDEDKNI--KELRVD------------------ 589

  Fly   730 DLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSL 794
                              :.|.:|:.|                      .|..||          
 Worm   590 ------------------IEPIIDEPA----------------------SFYRHD---------- 604

  Fly   795 RREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTT 859
              :..|.....:...:|:.....|....:.|:.: :|.|.....|....:||||||        .
 Worm   605 --KLIQSPEVERSASSVFQPYVLASAMFITAICI-IAFAITNARRRRAMRGFIEVD--------V 658

  Fly   860 HHPIVREEKIVPNMQINGYENPTYKYFEVK 889
            :.|   ||:.|..||:||||||||.:|:.|
 Worm   659 YTP---EERHVAGMQVNGYENPTYSFFDSK 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 72/184 (39%)
APP_N 33..141 CDD:280358 47/111 (42%)
APP_Cu_bd 143..198 CDD:289676 21/60 (35%)
APP_E2 387..580 CDD:289677 75/194 (39%)
GBP_C <629..682 CDD:303769 9/52 (17%)
APP_amyloid 834..887 CDD:287486 21/52 (40%)
apl-1NP_508870.3 A4_EXTRA 28..196 CDD:128326 71/178 (40%)
APP_N 36..133 CDD:280358 46/107 (43%)
APP_Cu_bd 135..196 CDD:289676 21/60 (35%)
APP_E2 238..423 CDD:289677 78/240 (33%)
APP_amyloid 637..683 CDD:287486 23/56 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160163326
Domainoid 1 1.000 150 1.000 Domainoid score I2700
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 339 1.000 Inparanoid score I1401
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50020
OrthoDB 1 1.010 - - D405630at33208
OrthoFinder 1 1.000 - - FOG0001588
OrthoInspector 1 1.000 - - oto18144
orthoMCL 1 0.900 - - OOG6_104222
Panther 1 1.100 - - LDO PTHR23103
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2378
SonicParanoid 1 1.000 - - X996
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1313.030

Return to query results.
Submit another query.