DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Appl and Y43F8B.3

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001256874.1	Gene:	Y43F8B.3 / 180277	WormBaseID:	WBGene00012814	Length:	1658	Species:	Caenorhabditis elegans

Alignment Length:	236	Identity:	47/236 - (19%)
Similarity:	65/236 - (27%)	Gaps:	85/236 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCK 82
            :|:||.  .|..|||......:    |..|..|....|......|::....||    ...::.|.
Worm   866 MAVGTG--GATLPRWYYNAQTM----QCVQFNYAGRMGNQNNFQSQQACEQTC----PVYVNVCP 920

  Fly    83 KAYPNRDI-----------TNIVESSHYQKIGGWCRQGAL------------NAAKCKG------ 118
            ...|..|.           :|...:.|      ||..|.:            |...|:|
Worm   921 TGSPMLDASTNKPVPCTFGSNSCGADH------WCHLGLVPDEYQCCPGSPTNPGACQGLPESEG 979

  Fly   119 --------SHRW--------IKPFRCLG-PFQSDALLVPEGCLFDHIHNASRCWPFVR-WNQ--- 162
                    :.||        .|.|...| ....:..|..|.|       |:.|..|.. .||
Worm   980 VTGAPAPPTSRWYYDQTDMQCKQFTYNGRRGNQNNFLTQEDC-------AATCDVFTNPCNQPIA 1037

  Fly   163 TGAAACQERGMQMRSFAMLLPCGISVFSGV-----EFVCCP 198
            ..|..|...|...       .||.:::..:     ..||||
Worm  1038 LPATLCSGTGSSD-------TCGANMWCHIGANQDSTVCCP 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	42/226 (19%)
		APP_N	33..141	CDD:280358	24/153 (16%)
		APP_Cu_bd	143..198	CDD:289676	13/63 (21%)
		APP_E2	387..580	CDD:289677
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
Y43F8B.3	NP_001256874.1	KU	76..126	CDD:238057
		KU	129..182	CDD:238057
		Kunitz_BPTI	231..282	CDD:278443
		Lustrin_cystein	287..329	CDD:291299
		Kunitz_BPTI	335..386	CDD:278443
		Lustrin_cystein	393..434	CDD:291299
		KU	438..490	CDD:197529
		Lustrin_cystein	497..540	CDD:291299
		Kunitz_BPTI	545..596	CDD:278443
		KU	649..703	CDD:238057
		KU	752..804	CDD:238057
		Lustrin_cystein	811..853	CDD:291299
		Kunitz_BPTI	861..912	CDD:278443	12/51 (24%)
		Lustrin_cystein	919..962	CDD:291299	8/48 (17%)
		Kunitz_BPTI	981..1025	CDD:278443	9/50 (18%)
		Kunitz_BPTI	1076..1128	CDD:278443
		Lustrin_cystein	1132..1176	CDD:291299
		Kunitz_BPTI	1182..1234	CDD:278443
		Lustrin_cystein	1241..1282	CDD:291299
		Kunitz_BPTI	1287..1338	CDD:278443
		Kunitz_BPTI	1395..1447	CDD:278443
		Lustrin_cystein	1453..1492	CDD:291299
		Kunitz_BPTI	1499..1549	CDD:278443
		KU	1600..1652	CDD:197529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2378
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030