Protein Alignment Appl and F22E12.1

DIOPT Version :9

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_505684.2
• Gene: F22E12.1 / 179460
• WormBaseID: WBGene00009058
• Length: 763
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 101/583 - (17%)
• Similarity: 201/583 - (34%)
• Gaps: 168/583 - (28%)

  Fly   294 NAEYDSGE----EGDNYEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAP 354
            |:.|||..    ..||                 ||..  ...:::......||....|||
 Worm   191 NSYYDSHPRRYGNSDN-----------------WDNK--LMTINISHRDDGPSYFHAAPA----- 231

  Fly   355 VKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTSDPYFTHFDPHYEHQSYKVSQ--- 416
                  .:.|..|.:|.:|.....|.:.....:.|...|....      |.:::.|....:|
 Worm   232 ------VTVPMFSRAAQSFKTQADGLTIHRYDSEPRPMQVLDQ------DVNWQIQEQASAQQNG 284

  Fly   417 --KRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTA--------RFQTSVQALE 471
              ||..:..::|:...|            :.|....|:||...|:..        |..|.....|
 Worm   285 FMKRRFKMQKKKLPPRM------------IHLGTRPASQSNSYRIQLDSEINEHNRPVTYQVVRE 337

  Fly   472 EEGNAEKHQLAAMHQQRVLAHINQRKREAM--TCYTQALTEQPP-------------------NA 515
            ::.:.::|...:...|.......:|.::.|  ..:.||..::||                   |.
 Worm   338 QDAHVQQHNQISQSLQNEAEETQRRIQDTMRRNYFEQARYQRPPVQMPPPPPPPQQNSPSVNENY 402

  Fly   516 H---------HV---EKCLQKLLRALHKDRAHALAHYRHLLNSGGPGG-------LEAAASERPR 561
            |         |:   ||.|::.|.|...|  |.:....|:.....|.|       ::..|..:..
 Worm   403 HPELVNQFKSHLDEHEKALRRKLEAQFPD--HIITLIPHIETVRNPDGSNVVRQRIKWTAYPKGA 465

  Fly   562 TLERLIDIDRAVNQSMTMLKRYPELSAKIAQLM---------NDYILALRSKDDIPGSSLGMSEE 617
            .:...:.:     ..:..|...|.:...|..::         ..||..:.:   :|...:...:.
 Worm   466 RIPEHVPV-----PPVAQLPPLPPMQQVIQPILTTQAVYTTEEPYIPLITT---VPTHEISRLKH 522

  Fly   618 AEAGILDKYRVEIERKVAEKER-----------LRLAEKQRKEQRAAEREKLREEKLRLEAKKVD 671
            .|  :..||:.::|::..|::|           |:.|:::.:|:...||||...:: ||   |.:
 Worm   523 EE--MQRKYKEDLEKRQEEQKRQQEEHKKKIQELKAAQQRERERMMVEREKAENDR-RL---KYE 581

  Fly   672 DMLKSQVAEQQSQ------PTQSSTQSQAQQ--QQQEKSLPGKELGPDAALVTAANPNLETTKSE 728
            :.:|.:..|.|::      ||.::|.....:  .....:||..|:..||.:    ...:.|:||
 Worm   582 NEMKQRAEEYQARMRLTTIPTPTTTVETTTEYVHVPYPTLPVNEVVYDAHI----RKPIPTSKS- 641

  Fly   729 KDLSDTEYGEATVSTKVQTVLPTVDD-DAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRES 790
                        ::..|:...|.::: .....::||: .|:.:|.::.:.::.:..|....|:
 Worm   642 ------------IAEPVEHFRPIIENVTPASLSLEDI-IAMDNQRSDYEDEYDVPMDFPDTEA 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326
		APP_N	33..141	CDD:280358
		APP_Cu_bd	143..198	CDD:289676
		APP_E2	387..580	CDD:289677	39/245 (16%)
		GBP_C	<629..682	CDD:303769	15/63 (24%)
		APP_amyloid	834..887	CDD:287486
F22E12.1	NP_505684.2	KU	25..76	CDD:238057
		KU	85..138	CDD:238057

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900