DRSC/TRiP Functional Genomics Resources

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Protein Alignment Appl and ZC84.6

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_499035.2 Gene:ZC84.6 / 176299 WormBaseID:WBGene00013849 Length:1491 Species:Caenorhabditis elegans


Alignment Length:316 Identity:63/316 - (19%)
Similarity:99/316 - (31%) Gaps:125/316 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 ASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKK---------------------------- 64
            |:|  ||:    |..||.|:    ..:|::||..:.:                            
 Worm   509 AAP--EPR----CPQGQAYK----DNQGKFVTCTTNRQSSSCPANFECYFDGNMHGCCPTKAFTC 563

  Fly    65 ----TTGPTC------------LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCR------ 107
                :.|.||            ...:.:..:|......:....:..|..:|..:||...      
 Worm   564 SLSPSPGKTCGPGVSFKYHYNPQTQECESFEYLGCDGNSNTFASRAECENYCGVGGCANGGSPLR 628

  Fly   108 --QGALNAAK-----CKGSHRW--------IKPFRC---------LGPFQ-----SDALLVPEGC 143
              .|||.:..     |..||..        :..:||         |.|.|     |..|.|....
 Worm   629 DSNGALQSCSERDGGCPSSHECYGVSLGPDMMSYRCCPTKTYICGLPPQQGSSLCSGGLTVVTRY 693

  Fly   144 LFDHIHNASRCWPFV----RWNQTGAAACQERGMQMRSFAMLLPC--GISVF----SGVEFVC-- 196
            .|:.:  ..:|.|||    ..|....|:..    |..:|.|...|  |..|:    :.:...|  
 Worm   694 YFNIV--TRKCSPFVYNGCDGNPNNFASLN----QCNNFCMASACNAGDVVYLNPNTALPISCND 752

  Fly   197 -----CPKHFK------TDE-IHVKKTDLPVMP---AAQINSAND---ELVMNDED 234
                 |||.|:      ||: :....||:.|.|   .|.|||.:.   |.::|:.:
 Worm   753 ELQNNCPKSFQCIYDSLTDQSVCCGATDMGVCPDNEKAYINSMDGTVRECLINEHN 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 47/265 (18%)
APP_N 33..141 CDD:280358 31/186 (17%)
APP_Cu_bd 143..198 CDD:289676 14/71 (20%)
APP_E2 387..580 CDD:289677
GBP_C <629..682 CDD:303769
APP_amyloid 834..887 CDD:287486
ZC84.6NP_499035.2 KU 230..286 CDD:197529
KU <368..409 CDD:197529
Kunitz_BPTI 455..507 CDD:278443
Lustrin_cystein 515..557 CDD:291299 7/45 (16%)
Kunitz_BPTI 562..616 CDD:278443 6/53 (11%)
Kunitz_BPTI 671..728 CDD:278443 15/62 (24%)
Lustrin_cystein 1003..1046 CDD:291299
EB 1100..1151 CDD:279949
EB 1162..1213 CDD:279949
Endonuclease_V <1390..1409 CDD:294433
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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