Protein Alignment Appl and appb

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: XP_068079378.1
• Gene: appb / 170846
• ZFINID: ZDB-GENE-020220-1
• Length: 751
• Species: Danio rerio
• Alignment Length: 931
• Identity: 230/931 - (24%)
• Similarity: 356/931 - (38%)
• Gaps: 244/931 - (26%)

  Fly     9 LLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLS-EEGRWVTDLSKKTTGPTCLR 72
            |||....:.|||......:.....|||:|:.|  |::  ..::: :.|:|..|   .|...:|:.
Zfish     9 LLLMLTTLSLAIEVPSDDSVGLLAEPQVAMFC--GKL--NMHINVQSGKWEPD---PTGTKSCIS 66

  Fly    73 DKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDA 136
            .|..:|.||::.||:..|||:||::....|..||:.|   ..:|:.....:.|:||| |.|.|||
Zfish    67 TKEGILQYCQEVYPDLQITNVVEANQPVSIQNWCKMG---RRQCRSHTHIVVPYRCLVGEFVSDA 128

  Fly   137 LLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCP--- 198
            ||||:.|.|.|......|...:.|:.....:|.:|.|.:..:.|||||||..|.||||||||
Zfish   129 LLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCGIDRFRGVEFVCCPMEE 193

  Fly   199 -KHFKTDE------------IHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDL 250
             |...::|            ...:.||..|: ..|:.:..|..|..|::|.|:.......|::|.
Zfish   194 QKDLDSEEQEEANSDVWWGGAETEYTDASVL-KEQVTAKPDPAVTEDDEDLNNEEDQVWDNDEDG 257

  Fly   251 DDEDDLMGDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSES 315
            |.|||   :|||||   ||                      ||..|.|:.|:..|.......:.:
Zfish   258 DGEDD---EDEEDD---DE----------------------DIIDEQDTSEQTSNIAMTTTTTTT 294

  Fly   316 EAEVE-----ASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVA 375
            ...:|     ..|                    ||....|..|.:......:.   ....|:|..
Zfish   295 TESIEEVVRAVCW--------------------APARSGPCHAKLPRWYFVAE---KGRCASFTF 336

  Fly   376 ANSGNSGTG-------AGAPPSTAQPTSDPYFTHFDPHY--------EHQSYKVSQKRLEESHRE 425
            ...|.:...       .....|:..||..|........|        ||..::.:::.||..|||
Zfish   337 GGCGGNRNNFESEEYCMAVCSSSVLPTMAPSPADAVDRYLEAPGDINEHMRFQKAKESLEAKHRE 401

  Fly   426 KVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVL 490
            |::.||::|.:.|.:.:::..||       |:.:..|||..|::||:|...|:.||...|..||.
Zfish   402 KMSEVMREWEEAERQAKNLPRAD-------KKTIIQRFQEKVESLEKEAAGERQQLVETHMARVE 459

  Fly   491 AHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAA 555
            |.:|.|:|:|:..|..:|....|....|...|:|.:||..|||.|.|.|:.| :....|   :.|
Zfish   460 ALLNDRRRQALESYLSSLQSDQPRPRQVLNLLKKYIRAEQKDRQHTLKHFEH-VREVDP---KKA 520

  Fly   556 ASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEA 620
            :..||..:..|..|:..:|||:..|.:.|       |:.||
Zfish   521 SQIRPFVMTHLRVIEERMNQSLGYLYKVP-------QVAND------------------------ 554

  Fly   621 GILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQP 685
             |.|:..|.::|                                                .|::.
Zfish   555 -IQDQVAVLVQR------------------------------------------------DQAEV 570

  Fly   686 TQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKD----LSDTEYGEATVSTKVQ 746
            ||   |..:.|.:...|.....|.||  |..:..| |:....|:|    :....:.:|.....|:
Zfish   571 TQ---QLSSLQSKMRVSYGNDALMPD--LPDSTTP-LDNLPPEQDGLGFIHPESFNQANTDNHVE 629

  Fly   747 TV---------LPTVDD-DAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQH 801
            .|         |||..: ..|:..:|:  ...|..:...:...|:..|:|
Zfish   630 PVDARPIPERGLPTRPEIPKVRLDIEE--RHNAGYDVRDKRLMFLAEDMG--------------- 677

  Fly   802 AHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVRE 866
                 ..:.....|...|:.:...:.:.:.:.:.:...|.| .|.||||..          :..|
Zfish   678 -----SNKGAIIGLMVGGVVIATVIVITLVMLRKKQYTSIH-HGVIEVDAA----------VTPE 726

  Fly   867 EKIVPNMQINGYENPTYKYFE 887
            |:.:..||.|||||||||:||
Zfish   727 ERHLAKMQQNGYENPTYKFFE 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	62/173 (36%)
		APP_E2	388..580	CDD:463752	62/199 (31%)
		DDRGK	632..>682	CDD:370664	1/49 (2%)
		APP_amyloid	834..887	CDD:463129	20/52 (38%)
appb	XP_068079378.1	A4_EXTRA	29..190	CDD:128326	62/170 (36%)
		Kunitz_ABPP-like	305..356	CDD:438650	8/73 (11%)
		APP_E2	363..545	CDD:463752	60/192 (31%)
		JMTM_Notch_APP	672..748	CDD:425406	26/107 (24%)