Protein Alignment Appl and Appl

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: XP_061503924.1
• Gene: Appl / 1273174
• VectorBaseID: AGAMI1_008885
• Length: 909
• Species: Anopheles gambiae
• Alignment Length: 951
• Identity: 589/951 - (61%)
• Similarity: 675/951 - (70%)
• Gaps: 118/951 - (12%)

  Fly    13 SLW-------VVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTC 70
            |:|       :|....|...|||||||||||:|||||||.|.||:|||||||.||||.|..|.||
Mosquito     4 SVWPVAFALVLVTLYSTVPSQAASPRWEPQISVLCEAGQTYHPQFLSEEGRWTTDLSIKVPGSTC 68

  Fly    71 LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQS 134
            |||||||||||||.||.|||||||||||||||||||||||||||||||:.||||||||| |||||
Mosquito    69 LRDKMDLLDYCKKVYPGRDITNIVESSHYQKIGGWCRQGALNAAKCKGAQRWIKPFRCLEGPFQS 133

  Fly   135 DALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPK 199
            |||||||||||||||||||||||||||||||||||:|.|||||||||||||||:|||||||||||
Mosquito   134 DALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQDRNMQMRSFAMLLPCGISLFSGVEFVCCPK 198

  Fly   200 HFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDD 264
            |||...:.||||||||:|       .|..::...||.:|.  :.|.|.:| |:|:|.|.|:|:::
Mosquito   199 HFKAVPMKVKKTDLPVLP-------QDTDMLPALDDGSDG--ASDNNSED-DEEEDEMDDEEDEE 253

  Fly   265 MVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDN-YEEDGAGSESEAEVEASWDQSGG 328
            |:.||...                |.||   ||||.|:.|: .::..||:::.....|:||
Mosquito   254 MLGDEPIE----------------SEDD---EYDSDEDFDSGSDKPAAGADTIDTGSAAWD---- 295

  Fly   329 AKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTS--TPQLSASAAAFVAANSGNSGTGA---GAP 388
                      |..:..|.|...:.|..|.:...|  ...|.|:|..:.||:|.....|.   ...
Mosquito   296 ----------SFTTPPPPATGNKDALKKQQQPDSLGAGMLYAAAGGYAAASSTERAAGGIELVTT 350

  Fly   389 PSTAQPTSDPYFTHFDPHYEHQSYK-------VSQKRLEESHREKVTRVMKDWSDLEEKYQDMRL 446
            |.||.||.|||||||||..||||:|       .:|:|||||||||||||||||||||||||||||
Mosquito   351 PITAIPTPDPYFTHFDPRNEHQSFKNLHAEFQEAQQRLEESHREKVTRVMKDWSDLEEKYQDMRL 415

  Fly   447 ADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQ 511
            ||||:||:|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
Mosquito   416 ADPKSAQTFKQRMTARFQTSVQALEEEGNSEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQ 480

  Fly   512 PPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQS 576
            ||::|.||||||||||||||||||||:||||||.|||.|||||||||||||||||:|||||||||
Mosquito   481 PPSSHRVEKCLQKLLRALHKDRAHALSHYRHLLGSGGTGGLEAAASERPRTLERLVDIDRAVNQS 545

  Fly   577 MTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLR 641
            |.|||||||||.|::|||:|||.||||||:.|||.|.|:|||||.||||||:||||||:||||.|
Mosquito   546 MAMLKRYPELSVKLSQLMDDYIQALRSKDETPGSMLAMTEEAEAAILDKYRMEIERKVSEKERQR 610

  Fly   642 LAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGK 706
            |||||||||||.||||:|||||||||||::...|.|..:||.|..|...|.|.|:|||.:....:
Mosquito   611 LAEKQRKEQRAQEREKIREEKLRLEAKKMEAAYKQQQQQQQQQQQQQQQQQQQQKQQQAQQQAQQ 675

  Fly   707 ELGPDAALVTAA-------------------NPNL----ETTKSEKDL---SDTE----YGEATV 741
            :....||...|.                   .|.|    :|.|.:.|:   .:||    |.|..|
Mosquito   676 QAQMIAATFAATQQQQQQQQQQQQQQSMQTQQPTLSEQPQTQKQQPDMEAQKETETTKDYSEEAV 740

  Fly   742 STKVQ-TVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAA 805
            .|..| |.||||||:|||||||:||||||||||||::||.:.||:||.|.|:|:|||.  ::.:.
Mosquito   741 VTSPQPTALPTVDDEAVQRAVEEVAAAVAHQEAEPKMQHVLAHDIGHGEPSYSVRREV--YSSSG 803

  Fly   806 KEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVG--------CQNVTTHH- 861
            ::.:|||||:.|||||||||||||||||||:.|||||||||:|||||.        |..:..|:
Mosquito   804 RDSKNVYFTVGFAGIALMAAVFVGVAVAKWKASRSPHAQGFVEVDQVSGATGHGQRCPGIVLHYN 868

  Fly   862 ------------PIVREEKIVPNMQINGYENPTYKYFEVKE 890
                        |:..||:.|.||||||||||||||||:||
Mosquito   869 SNILPVFQAVGAPVTPEERHVANMQINGYENPTYKYFEIKE 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	155/172 (90%)
		APP_E2	388..580	CDD:463752	170/198 (86%)
		DDRGK	632..>682	CDD:370664	36/49 (73%)
		APP_amyloid	834..887	CDD:463129	36/73 (49%)
Appl	XP_061503924.1	None