DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Appl and App

DIOPT Version :10

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_001185752.1 Gene:App / 11820 MGIID:88059 Length:770 Species:Mus musculus


Alignment Length:951 Identity:239/951 - (25%)
Similarity:380/951 - (39%) Gaps:263/951 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLLRSLWVVLAI-----GTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGP 68
            |||.:.|.|.|:     |.|.:.|     |||||:.|  |::.....: :.|:|.:|.|..   .
Mouse     7 LLLLAAWTVRALEVPTDGNAGLLA-----EPQIAMFC--GKLNMHMNV-QNGKWESDPSGT---K 60

  Fly    69 TCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPF 132
            ||:..|..:|.||::.||...|||:||::....|..||::|   ..:||.....:.|:||| |.|
Mouse    61 TCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRG---RKQCKTHTHIVIPYRCLVGEF 122

  Fly   133 QSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCC 197
            .|||||||:.|.|.|......|...:.|:......|.|:...:..:.|||||||..|.|||||||
Mouse   123 VSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCC 187

  Fly   198 PKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSN------DSNYS-------------- 242
            |...::|               .::||:.|     ||||:      |::|:              
Mouse   188 PLAEESD---------------SVDSADAE-----EDDSDVWWGGADTDYADGGEDKVVEVAEEE 232

  Fly   243 --KDANEDDLDDEDDLMGDDEEDDMVAD--EAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEG 303
              .|..|::.||::|:...||.::...:  |.||. .:.:|.::..:.:.|::::..|..| |:.
Mouse   233 EVADVEEEEADDDEDVEDGDEVEEEAEEPYEEATE-RTTSTATTTTTTTESVEEVVREVCS-EQA 295

  Fly   304 DN-----------------------YEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAP 345
            :.                       |...|....:....|......|.....||...:|.    |
Mouse   296 ETGPCRAMISRWYFDVTEGKCVPFFYGGCGGNRNNFDTEEYCMAVCGSVSTQSLLKTTSE----P 356

  Fly   346 VAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTSDPYFTHFDPHYEHQ 410
            :...|:|.|.                           |.|..|.:.     |.|........||.
Mouse   357 LPQDPDKLPT---------------------------TAASTPDAV-----DKYLETPGDENEHA 389

  Fly   411 SYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGN 475
            .::.:::|||..|||::::||::|.:.|.:.:::..||.||       :...||..|::||:|..
Mouse   390 HFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKA-------VIQHFQEKVESLEQEAA 447

  Fly   476 AEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHY 540
            .|:.||...|..||.|.:|.|:|.|:..|..||...||..|||...|:|.:||..|||.|.|.|:
Mouse   448 NERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHF 512

  Fly   541 RHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKD 605
            .| :....|   :.||..|.:.:..|..|...:|||:::|...|.::.:|             :|
Mouse   513 EH-VRMVDP---KKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEI-------------QD 560

  Fly   606 DIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKV 670
            ::                                                    :|.|:.|....
Mouse   561 EV----------------------------------------------------DELLQKEQNYS 573

  Fly   671 DDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKS-------- 727
            ||:|.:.::|                       |....|.||.:     |:|..||:        
Mouse   574 DDVLANMISE-----------------------PRISYGNDALM-----PSLTETKTTVELLPVN 610

  Fly   728 -EKDLSDTE----YGEATVSTKVQTVLPTVD-DDAVQRAVED-VAAAVAHQEAEPQVQHFMTHDL 785
             |..|.|.:    :|..:|....:..:..|| ..|..|.:.. ..:.:.:.:.|...:..|..:.
Mouse   611 GEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEF 675

  Fly   786 GHRESSFSLRRE----FAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGF 846
            || :|.|.:|.:    ||:...:.|   .....|...|:.:...:.:.:.:.|.:...|.| .|.
Mouse   676 GH-DSGFEVRHQKLVFFAEDVGSNK---GAIIGLMVGGVVIATVIVITLVMLKKKQYTSIH-HGV 735

  Fly   847 IEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887
            :|||..          :..||:.:..||.|||||||||:||
Mouse   736 VEVDAA----------VTPEERHLSKMQQNGYENPTYKFFE 766

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 65/172 (38%)
APP_E2 388..580 CDD:463752 64/191 (34%)
DDRGK 632..>682 CDD:370664 7/49 (14%)
APP_amyloid 834..887 CDD:463129 20/52 (38%)
AppNP_001185752.1 A4_EXTRA 24..188 CDD:128326 67/177 (38%)
GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 28..123 36/108 (33%)
CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 131..189 22/57 (39%)
Zinc-binding. /evidence=ECO:0000250 181..188 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..284 22/111 (20%)
Kunitz_ABPP-like 294..341 CDD:438650 3/46 (7%)
OX-2. /evidence=ECO:0000250|UniProtKB:P05067 344..365 6/24 (25%)
APP_E2 366..548 CDD:463752 66/224 (29%)
Heparin-binding. /evidence=ECO:0000250 391..423 10/31 (32%)
Heparin-binding. /evidence=ECO:0000250 491..522 12/34 (35%)
Collagen-binding. /evidence=ECO:0000250|UniProtKB:P05067 523..540 5/16 (31%)
JMTM_Notch_APP 693..767 CDD:425406 25/88 (28%)
Interaction with PSEN1. /evidence=ECO:0000250|UniProtKB:P05067 695..722 3/29 (10%)
Basolateral sorting signal 724..734 3/10 (30%)
Interaction with G(o)-alpha. /evidence=ECO:0000250 732..751 7/29 (24%)
Interaction with DAB2. /evidence=ECO:0000269|PubMed:11247302 756..770 10/11 (91%)
Required for the interaction with KIF5B and for anterograde transport in axons. /evidence=ECO:0000250|UniProtKB:P05067 756..770 10/11 (91%)
YENPXY motif, contains endocytosis signal. /evidence=ECO:0000250|UniProtKB:P05067 757..762 4/4 (100%)

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