DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Appl and Aplp2

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001344627.1	Gene:	Aplp2 / 11804	MGIID:	88047	Length:	763	Species:	Mus musculus

Alignment Length:	923	Identity:	242/923 - (26%)
Similarity:	375/923 - (40%)	Gaps:	227/923 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LWVVLAIGTAQVQAASPRW---------------EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSK 63
            |.|:|.:|.....||...:               |||||:.|  |::.....: :.|:|..|
Mouse    15 LLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFC--GKLNMHVNI-QTGKWEPD--- 73

  Fly    64 KTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRC 128
            .|...:||..|.::|.||::.||...|||::|::....|..|||:   :..:|| ||..| ||:|
Mouse    74 PTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRR---DKRQCK-SHIVI-PFKC 133

  Fly   129 L-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGV 192
            | |.|.||.||||:.|.|.|......|....||:.....||...|:.:.|:.||||||:..|.|.
Mouse   134 LVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGT 198

  Fly   193 EFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLM 257
            |:||||   :|..:....|    |...:.....||   .||::..|.:.|:...|.||:|..:..
Mouse   199 EYVCCP---QTKTVDSDST----MSKEEEEEEEDE---EDEEEDYDLDKSEFPTEADLEDFTEAA 253

  Fly   258 GDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEED------GAGSESE 316
            .|:||:|....|..                  ::|.:..||. .:||:|.|:      ..|:.|:
Mouse   254 ADEEEEDEEEGEEV------------------VEDRDYYYDP-FKGDDYNEENPTEPSSEGTISD 299

  Fly   317 AEVEASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNS 381
            .|:...      .|.|..:...:.|..| |.|.......|.:.|           .|:....|.:
Mouse   300 KEIVHD------VKAVCSQEAMTGPCRA-VMPRWYFDLSKGKCV-----------RFIYGGCGGN 346

  Fly   382 GTG------------AGAPPSTAQPTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMK 432
            ...            |..|| |..||:  |.||.......||..::.::::||..||.::.||.|
Mouse   347 RNNFESEDYCMAVCKAMIPP-TPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKK 410

  Fly   433 DWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRK 497
            :|.:.|.:.:::    ||..   :|.:...||..|:|||:|..:||.||...|..||.|.:|.|:
Mouse   411 EWEEAELQAKNL----PKTE---RQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRR 468

  Fly   498 REAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRT 562
            |.|:..|..||...||..|.:.:.|::.:||.:|||.|.:.||:|:| :..|   |.||..:.:.
Mouse   469 RIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL-AVDP---EKAAQMKSQV 529

  Fly   563 LERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYR 627
            :..|..|:...|||:::|.:.|    .:||
Mouse   530 MTHLHVIEERRNQSLSLLYKVP----YVAQ----------------------------------- 555

  Fly   628 VEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQS 692
             ||:.::.|     |.::||.:.                     |...|.::|.......||.:|
Mouse   556 -EIQEEIDE-----LLQEQRADM---------------------DQFTSSISENPVDVRVSSEES 593

  Fly   693 QAQQQQQEKSLPGKELGPDAALVTAANPNLET-------TKSEKDLSDTEYGEATVSTKVQTVLP 750
                   |:..|...|.|..:|    :.|.:|       .|....:::.:.|......||.....
Mouse   594 -------EEIPPFHPLHPFPSL----SENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSKN 647

  Fly   751 TVDDDAVQRAVEDV------AAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGR 809
            .:|::.|.....||      |..|...|.||             ||...||.:|:..:
Mouse   648 KMDENMVIDETLDVKEMIFNAERVGGLEEEP-------------ESVGPLREDFSLSS------- 692

  Fly   810 NVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQ 874
            |....|....:|:...:.:.:.:.:.| .....:.|.:|||.:          :..||:.:..||
Mouse   693 NALIGLLVIAVAIATVIVISLVMLRKR-QYGTISHGIVEVDPM----------LTPEERHLNKMQ 746

  Fly   875 INGYENPTYKYFE 887
            .:|||||||||.|
Mouse   747 NHGYENPTYKYLE 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	67/187 (36%)
		APP_N	33..141	CDD:280358	43/108 (40%)
		APP_Cu_bd	143..198	CDD:289676	21/54 (39%)
		APP_E2	387..580	CDD:289677	67/194 (35%)
		GBP_C	<629..682	CDD:303769	9/52 (17%)
		APP_amyloid	834..887	CDD:287486	18/52 (35%)
Aplp2	NP_001344627.1	A4_EXTRA	42..204	CDD:128326	65/172 (38%)
		Kunitz_BPTI	309..361	CDD:278443	9/63 (14%)
		APP_E2	365..547	CDD:315580	67/193 (35%)
		APP_amyloid	709..759	CDD:313694	18/60 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844133
Domainoid	1	1.000	108	1.000	Domainoid score	I6427
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3265
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50020
OrthoDB	1	1.010	-	-		D405630at33208
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		otm43278
orthoMCL	1	0.900	-	-		OOG6_104222
Panther	1	1.100	-	-	O	PTHR23103
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2378
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.890