Protein Alignment Appl and Aplp1

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_031493.2
• Gene: Aplp1 / 11803
• MGIID: 88046
• Length: 654
• Species: Mus musculus
• Alignment Length: 891
• Identity: 204/891 - (22%)
• Similarity: 314/891 - (35%)
• Gaps: 280/891 - (31%)

  Fly     9 LLLRSLWVV--LAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCL 71
            ||||:...|  ||:|:.  .||......|:|.||  |::...:.| ..|||..|..:..   .||
Mouse    29 LLLRAQLAVGNLAVGSP--SAAEAPGSAQVAGLC--GRLTLHRDL-RTGRWEPDPQRSR---RCL 85

  Fly    72 RDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSD 135
            .|...:|:||::.||...|..:.:::....:..||  |...:.:|...|..:.||.|| |.|.|:
Mouse    86 LDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWC--GGTRSGRCAHPHHEVVPFHCLPGEFVSE 148

  Fly   136 ALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKH 200
            ||||||||.|.|.....:|....|.:|....||..:|:.:....||||||...|.|||:||||.
Mouse   149 ALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPP- 212

  Fly   201 FKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDM 265
                         |..|
Mouse   213 -------------PATP------------------------------------------------ 216

  Fly   266 VADEAATAGGSPNTGS--SGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGG 328
              :.:..|.|.|:|.|  .|....|..|:...|.......|.:.|.....|.|.|.|
Mouse   217 --NPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEE-------- 271

  Fly   329 AKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQ 393
                         ..||  |.....||....||.||                            :
Mouse   272 -------------ERAP--PPSSHTPVMVSRVTPTP----------------------------R 293

  Fly   394 PTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFK 456
            ||.  |.||.......||:.:..::..|||....::..||::|:..:.:.:::..||       :
Mouse   294 PTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKAD-------R 351

  Fly   457 QRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKC 521
            |.:...||:.:|.|||:.:.|:.:|...|..||:|.||.::|.|:..:..||...||.|..|...
Mouse   352 QALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMA 416

  Fly   522 LQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPEL 586
            |::.|||..|::.|.|.||:|:. :..|   |.|...|.:....|..|:..:|||:.:|.:.|.|
Mouse   417 LRRYLRAEQKEQRHTLRHYQHVA-AVDP---EKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHL 477

  Fly   587 SAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQR 651
            :.::...:.:.:||         ..||.||
Mouse   478 AQELRPQIQELLLA---------EHLGPSE----------------------------------- 498

  Fly   652 AAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVT 716
                         |:|               |.|..||....:.|..:.|.      .|...|..
Mouse   499 -------------LDA---------------SVPGSSSEDKGSLQPPESKD------DPPVTLPK 529

  Fly   717 AANPNLETTKSEKDLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFM 781
            .:.....::...:.|:..|..|..|:.......|....| :||           .|..|
Mouse   530 GSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSD-IQR-----------DELAP------ 576

  Fly   782 THDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAA-----VFVGVAVAKWRTSRSP 841
                    |...:.||                  :.:|:.:|.|     :.:.:.:.:.:.....
Mouse   577 --------SGTGVSRE------------------ALSGLLIMGAGGGSLIVLSLLLLRKKKPYGT 615

  Fly   842 HAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887
            .:.|.:|||.:          :..||:.:..:|.:|||||||::.|
Mouse   616 ISHGVVEVDPM----------LTLEEQQLRELQRHGYENPTYRFLE 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	61/172 (35%)
		APP_E2	388..580	CDD:463752	57/193 (30%)
		DDRGK	632..>682	CDD:370664	2/49 (4%)
		APP_amyloid	834..887	CDD:463129	14/52 (27%)
Aplp1	NP_031493.2	A4_EXTRA	46..211	CDD:128326	61/172 (35%)
		GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	50..146		29/103 (28%)
		CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	154..212		24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..297		27/183 (15%)
		APP_E2	289..471	CDD:463752	60/220 (27%)
		Heparin-binding. /evidence=ECO:0000250	314..346		6/31 (19%)
		Heparin-binding. /evidence=ECO:0000250	414..445		11/34 (32%)
		Collagen-binding. /evidence=ECO:0000250	446..463		4/16 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..580		23/177 (13%)
		JMTM_Notch_APP	568..652	CDD:425406	26/138 (19%)
		Basolateral sorting signal. /evidence=ECO:0000250	608..619		0/10 (0%)
		Interaction with DAB1	636..652		9/16 (56%)
		Interaction with DAB2. /evidence=ECO:0000269|PubMed:11247302	640..654		8/12 (67%)
		NPXY motif, contains endocytosis signal	644..647		2/2 (100%)