DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Appl and SPINT2

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_066925.1	Gene:	SPINT2 / 10653	HGNCID:	11247	Length:	252	Species:	Homo sapiens

Alignment Length:	67	Identity:	16/67 - (23%)
Similarity:	23/67 - (34%)	Gaps:	13/67 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 DSNDSNYSKDANEDDLDDEDDL-----MGDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDIN 294
            |.|.:||        |..|:.|     :.::...|:.....|.....|:.....||...|.|..|
Human    72 DGNSNNY--------LTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFN 128

  Fly   295 AE 296
            .|
Human   129 YE 130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326
		APP_N	33..141	CDD:280358
		APP_Cu_bd	143..198	CDD:289676
		APP_E2	387..580	CDD:289677
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
SPINT2	NP_066925.1	Kunitz_BPTI	37..88	CDD:394972	7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..122		4/21 (19%)
		Kunitz_BPTI	132..183	CDD:394972
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900