Protein Alignment Appl and aplp2

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: XP_017951425.2
• Gene: aplp2 / 100380132
• XenbaseID: XB-GENE-5894468
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 911
• Identity: 225/911 - (24%)
• Similarity: 353/911 - (38%)
• Gaps: 255/911 - (27%)

  Fly    33 EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESS 97
            |||:|:.|  |::.....: :.|:|..|.|..   .:|:..|.::|.||::.:|:..|||:||::
 Frog    38 EPQVAMFC--GKLNMHVNI-QTGKWEPDPSGT---KSCIGTKEEVLQYCQEVFPDLQITNVVEAN 96

  Fly    98 HYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWN 161
            ....|..||::|   ..:|||....:.||:|| |.|.||.|||||.|.|.|......|.....|:
 Frog    97 QPVSIDNWCKKG---KKQCKGHSHIVVPFKCLVGEFVSDVLLVPEKCKFFHKERMDVCEGHQHWH 158

  Fly   162 QTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSAND 226
            .....||....|.:.|:.|||||.:..|.|.|:||||:                      ....|
 Frog   159 NVAKEACMTEVMVLHSYGMLLPCAVDQFRGAEYVCCPQ----------------------TKILD 201

  Fly   227 ELVMNDEDDSNDSNYSKDANEDDLD----------DEDDLMGDDEEDDMVADEAATAGGSPNTGS 281
            |.:..:|::.:|    ::.:|||.|          |.:|.....||::.|.||.
 Frog   202 EALSKEEEEEDD----EEEDEDDYDLYKSEFPTEADVEDFTAAAEEEEEVEDEV----------- 251

  Fly   282 SGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPV 346
                    ::|.:..|      |||:::...:|:..|.......||...:..:||..|  ..|..
 Frog   252 --------VEDRDYYY------DNYKDEDYNNENPTEPPNERQPSGKDIITDVKSVCS--QEAMT 300

  Fly   347 APAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTG--------------AGAPPSTAQPTSD 397
            .|.....|.....:.     ......|:....|.:...              ....|:.|... |
 Frog   301 GPCRAMMPRWYFDLG-----QKKCVRFIYGGCGGNRNNFESEDYCMAVCKVMMAQTPAPADDV-D 359

  Fly   398 PYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTAR 462
            .||.......||..::.::::||..|..::.||.|:|.:.|.:.|.:    |||.   :|.:...
 Frog   360 VYFETLADDNEHARFQKAKEQLEVRHHNRMERVKKEWEEAESQAQSL----PKAE---RQTLIQH 417

  Fly   463 FQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLR 527
            ||.:|:|||:|..:||.||...|..||.|.:|.::|.|:..|..||....|..|.:.:.|::.:|
 Frog   418 FQATVKALEKEAASEKQQLVETHLARVEAMLNDKRRNALENYLSALQADSPRPHRILQALKRYVR 482

  Fly   528 ALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQ 592
            |.:|||.|.:.||.|:| :..|   |.||..:.:.:..|..|:..:|||:::|.:.|.
 Frog   483 AENKDRLHTIRHYHHVL-AVDP---EKAAQMKSQVMTHLHVIEERMNQSLSLLYKVPY------- 536

  Fly   593 LMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREK 657
                                         :.|:.:.||:         .|.::||.:.
 Frog   537 -----------------------------VADEIQDEID---------ELFQEQRTDM------- 556

  Fly   658 LREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLP--GKELGPDAALVTAANP 720
                          |...|..:|.|.....||.:|       |:.||  ||...|   ......|
 Frog   557 --------------DQFTSSFSESQGDVRVSSEES-------EEILPKDGKPFRP---FQVKTFP 597

  Fly   721 NLETTKSEKDLSDTEY------GEATVST------KVQTVLPTVDDDAVQRAVEDVAAAVAHQEA 773
            ::  |:||:...|:..      |.|.::|      |:.......|...|.....||...:.:.|.
 Frog   598 SI--TESEETQRDSYLPVRKGSGMADLNTLIGAEEKIINSKSKADQKVVIDETLDVKEMIFNAER 660

  Fly   774 ------EPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAV 832
                  ||             ::...||.||                 ||:..||:..:.:.||:
 Frog   661 VSGLVDEP-------------DTDGPLRNEF-----------------SFSSGALIGLLVIAVAI 695

  Fly   833 A-----------KWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYF 886
            |           |.:.....|  |.:|||.:          :..||:.:..||.:|||||||||.
 Frog   696 ATIIVISLVLLRKRQYGTISH--GIVEVDPM----------LTPEERHLNKMQNHGYENPTYKYL 748

  Fly   887 E 887
            |
 Frog   749 E 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	60/165 (36%)
		APP_E2	388..580	CDD:463752	63/191 (33%)
		DDRGK	632..>682	CDD:370664	6/49 (12%)
		APP_amyloid	834..887	CDD:463129	19/52 (37%)
aplp2	XP_017951425.2	A4_EXTRA	31..195	CDD:128326	60/165 (36%)
		Kunitz_ABPP-like	293..344	CDD:438650	6/57 (11%)
		APP_E2	350..531	CDD:463752	63/192 (33%)
		JMTM_APLP2	670..750	CDD:411992	31/109 (28%)