DRSC/TRiP Functional Genomics Resources

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Protein Alignment Appl and aplp1

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_001120906.1 Gene:aplp1 / 100151735 XenbaseID:XB-GENE-853203 Length:643 Species:Xenopus tropicalis


Alignment Length:893 Identity:212/893 - (23%)
Similarity:351/893 - (39%) Gaps:269/893 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLS-EEGRWVTDLSKKTTG- 67
            |:.:||..|..::|.   ||..:|   |.||:|:.|  |::  |.::. ..|:||:|    ..| 
 Frog     7 LKSSLLPASCLLLLG---AQCLSA---WRPQLALFC--GRV--PLHMDLTNGQWVSD----PRGI 57

  Fly    68 PTCL-RDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-G 130
            |:|: ..|.::|.||::.||...||.:.|::....:..||:   ...::|||....:.|:.|| |
 Frog    58 PSCIGSSKDEILKYCREIYPELQITGVAEAAQPVTVTNWCQ---TQRSECKGHQHIVVPYHCLVG 119

  Fly   131 PFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFV 195
            .|.|||||||:.|.|.|......|..:..|::|...||....:.:.|:.|||||.:..|.|||:|
 Frog   120 EFVSDALLVPDKCRFLHREQMDVCESYQHWHETARTACAAEDLDLHSYGMLLPCRLDRFRGVEYV 184

  Fly   196 CCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDD 260
            |||          .:..|||.|...:.|...|                   .::.:.||::..||
 Frog   185 CCP----------TRNPLPVEPTQGLPSPTPE-------------------PEEPEKEDEVEIDD 220

  Fly   261 EEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQ 325
            :..::|                                  |||   .||.||:|::....|.||.
 Frog   221 DNIEVV----------------------------------EEG---AEDPAGAETDQHTPAIWDD 248

  Fly   326 SGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPS 390
                ..|....:..:.|:||..|               |::..|                     
 Frog   249 ----YFVGPGDEEETTSAAPTLP---------------PEVKVS--------------------- 273

  Fly   391 TAQPTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQ 453
              :||.  |.||.......||.::..::..|||...:::..|||:|:  |..||...|  ||   
 Frog   274 --RPTDGVDIYFESPREGSEHANFLRAKMELEERRMKQINEVMKEWA--EADYQAKNL--PK--- 329

  Fly   454 SFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHV 518
            |.:|.:...|||.:|.||.:.:|::.:|...|..||:|.:|..:|.|:..|..::...|.:...|
 Frog   330 SDRQAINEHFQTILQTLEGQISAQRQRLVETHLGRVVASLNDNRRGALENYLASVQATPLDPERV 394

  Fly   519 EKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRY 583
            ...|::.:||..:|:.|.:.||:| ::|..|   :.|.:.:.:.|..|..|:..||||:::|.|.
 Frog   395 LLALKRYIRAEQRDQRHTVRHYQH-VSSAEP---DRAETIQFQVLTHLRVIEERVNQSLSLLYRN 455

  Fly   584 PELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRK 648
            |:|:.::...:..::               .:|...||.|                  |:..|: 
 Frog   456 PQLTPELRDQIESWL---------------RTEWVGAGDL------------------LSSTQK- 486

  Fly   649 EQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAA 713
                    |:.|:              |...|.:..|..|:..||.:..||              
 Frog   487 --------KMNED--------------SDYPEIRVPPQNSAETSQGEDSQQ-------------- 515

  Fly   714 LVTAANPNLETTKSEK-DLSDTEYGEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQV 777
                    :|...|.. ||    |.:...|.:..|.....|:.:|::.                 
 Frog   516 --------IERKGSAVWDL----YSDFPPSERTLTFPGPKDNGSVKQV----------------- 551

  Fly   778 QHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPH 842
             |:.:.|         ::|:..:........|.....|....:|:...:.:.:.:.:    |.|:
 Frog   552 -HYQSED---------IQRDQLEPDTLVTFNRGALIGLLVVAVAVAMVIIISLLLIR----RKPY 602

  Fly   843 ---AQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYFE 887
               :.|.|||:       .:..|   |:|.:..||..|||||||:|.|
 Frog   603 GTISHGIIEVE-------ASRSP---EDKHLSKMQNQGYENPTYRYLE 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 61/175 (35%)
APP_N 33..141 CDD:280358 38/111 (34%)
APP_Cu_bd 143..198 CDD:289676 20/54 (37%)
APP_E2 387..580 CDD:289677 58/194 (30%)
GBP_C <629..682 CDD:303769 6/52 (12%)
APP_amyloid 834..887 CDD:287486 19/55 (35%)
aplp1NP_001120906.1 A4_EXTRA 28..187 CDD:128326 60/169 (36%)
APP_N 30..130 CDD:280358 38/110 (35%)
APP_Cu_bd 132..187 CDD:289676 20/54 (37%)
APP_E2 270..452 CDD:289677 59/215 (27%)
APP_amyloid 593..640 CDD:287486 19/60 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 109 1.000 Domainoid score I6271
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I3201
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D405630at33208
OrthoFinder 1 1.000 - - FOG0001588
OrthoInspector 1 1.000 - - otm48427
Panther 1 1.100 - - LDO PTHR23103
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X996
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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