DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4293 and ERV41

DIOPT Version :9

Sequence 1:	NP_001033816.1	Gene:	CG4293 / 31001	FlyBaseID:	FBgn0024983	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_013644.1	Gene:	ERV41 / 854935	SGDID:	S000004532	Length:	352	Species:	Saccharomyces cerevisiae

Alignment Length:	354	Identity:	94/354 - (26%)
Similarity:	151/354 - (42%)	Gaps:	40/354 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KNLDAFKKVPEKYTETSEIGGTLSLLSRLLIVYLVYTELHYYWHETDIVYQFEPDIALDEQVQMH 83
            |..|||.|..|:|.:.|..||..|||:.|.::::.:||...|:... |..|:..|..:.:.||::
Yeast     5 KTFDAFPKTEEQYKKKSTKGGLTSLLTYLFLLFIAWTEFGEYFGGY-IDQQYVVDSQVRDTVQIN 68

  Fly    84 VDITVAMPCASLSGVDLMDETQQDVFAYGTLQREGVWWEMSEHDRLQFQAIQIQNHYLREEFHSV 148
            :||.|...|..|. :::.|:|.........||.|    ||........:...| |..:..|...:
Yeast    69 MDIYVNTKCDWLQ-INVRDQTMDRKLVLEELQLE----EMPFFIPYDTKVNDI-NEIITPELDEI 127

  Fly   149 ADVLFKDIMRDNHPARESASKAPAAPPPGALPLSVDLHGRHNVQPESKFDACRLHGTLGINKVAG 213
            .........|:....|....::.  |....||               :|:.|.:.|::.:|:|:|
Yeast   128 LGEAIPAEFREKLDTRSFFDESD--PNKAHLP---------------EFNGCHVFGSIPVNRVSG 175

  Fly   214 VLHLVGGAQPVVGLFEDHWMIELRRMP---ANFTHRINRLSFGQYSGRIVQPLEGD-EIVIHEEA 274
            .|.:...:...|.         .|:.|   ..|.|.||..|||.:...|..||:.. :....|..
Yeast   176 ELQITAKSLGYVA---------SRKAPLEELKFNHVINEFSFGDFYPYIDNPLDNTAQFNQDEPL 231

  Fly   275 TTVQYFLKVVPTEIHQTFTTIYAFQYAVTENVRKLDSERNSYGS--PGIYFKYDWSALKIIVRND 337
            ||..|:..||||...:....:...||:|.: .|.|..:..:.|.  |||:|||::..|.|:|.:.
Yeast   232 TTYVYYTSVVPTLFKKLGAEVDTNQYSVND-YRYLYKDVAAKGDKMPGIFFKYNFEPLSIVVSDV 295

  Fly   338 RDHLVTFAIRLCSIISGIIVISGAINALL 366
            |...:.|.:||.:|.|.::..:..|..||
Yeast   296 RLSFIQFLVRLVAICSFLVYCASWIFTLL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4293	NP_001033816.1	ERGIC_N	19..104	CDD:290561	28/84 (33%)
CG4293	NP_001033816.1	COPIIcoated_ERV	<200..349	CDD:285244	45/154 (29%)
ERV41	NP_013644.1	ERGIC_N	4..92	CDD:404692	29/88 (33%)
ERV41	NP_013644.1	COPIIcoated_ERV	<161..320	CDD:400361	48/168 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345799
Domainoid	1	1.000	46	1.000	Domainoid score	I3073
eggNOG	1	0.900	-	-		E1_COG0445
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6574
Inparanoid	1	1.050	92	1.000	Inparanoid score	I1530
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52864
OrthoFinder	1	1.000	-	-		FOG0004385
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105529
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5010
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.730