DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4293 and si:ch211-225b10.3

DIOPT Version :9

Sequence 1:	NP_001033816.1	Gene:	CG4293 / 31001	FlyBaseID:	FBgn0024983	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_003199668.2	Gene:	si:ch211-225b10.3 / 557041	ZFINID:	ZDB-GENE-130531-53	Length:	365	Species:	Danio rerio

Alignment Length:	390	Identity:	127/390 - (32%)
Similarity:	197/390 - (50%)	Gaps:	51/390 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LEFAKNLDAFKKVPEKYTETSEIGGTLSLLSRLLIVYLVYTELHYYWHETDIVYQFEPDIALDEQ 79
            :...||||||.||||.|..||..|||::|...:|:..|..:|...| .:|.:.|::|.|.....:
Zfish    12 ISIIKNLDAFPKVPESYVATSAFGGTVTLTVFILMALLTISEFFVY-QDTWMKYEYEVDRDFTSK 75

  Fly    80 VQMHVDITVAMPCASLSGVDLMD---------ETQQDVFAYGTLQREGVWWEMSEHDRLQFQAIQ 135
            :::.:||||||.|..| |.|::|         |.:.|..::....::..|:::.:         |
Zfish    76 LKIKIDITVAMKCERL-GADVLDIAGAVVASKEIKYDSVSFDPSAQKKQWYQILQ---------Q 130

  Fly   136 IQNHYLREEFHSVADVLFKDIMRDNHPARESASKAPAAPPPGALPLSVDLHGRHNVQPESKFDAC 200
            |||. |||| .|:.|||||..::...     :..||...|                .|||: :||
Zfish   131 IQNR-LREE-QSLQDVLFKSALKGYF-----SDPAPRVDP----------------TPESQ-NAC 171

  Fly   201 RLHGTLGINKVAGVLHLVGGAQPVVGLFEDHWMIELRRMPANFTHRINRLSFGQYSGRIVQPLEG 265
            |:||.:.:|||||..|:..|..........|:...::....||:|||:.||||......:.||:|
Zfish   172 RIHGKIYVNKVAGNFHITLGKPIETHKGHAHYASFIKDEVYNFSHRIDHLSFGNDVPGHINPLDG 236

  Fly   266 DEIVIHEEATTVQYFLKVVPTEIHQTFTTIYAFQYAVTENVRKLDSERNSYGSPGIYFKYDWSAL 330
            .|....|:.|..|||:.||||::|.:..::...|::|||..|.:.:|:.:.|..||:|||..|.|
Zfish   237 MEKTTLEQNTLFQYFITVVPTKLHTSNVSVDMHQFSVTERERVVSNEKGNQGVSGIFFKYKLSPL 301

  Fly   331 KIIVRNDRDHLVTFAIRLCSIISGIIVISGAINAL------LLSIRSRLLRTFAPVLYNRLTRAK 389
            .:.|..:...|..|.:|||.|:.||...|..::.|      ::..|.||......|| ||:::::
Zfish   302 MVRVSEEHMPLAAFLVRLCGIVGGIFSTSDLLHRLIGSFVDIICFRFRLANKDREVL-NRVSQSE 365

Fly 390 389
Zfish 366 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4293	NP_001033816.1	ERGIC_N	19..104	CDD:290561	36/93 (39%)
CG4293	NP_001033816.1	COPIIcoated_ERV	<200..349	CDD:285244	53/148 (36%)
si:ch211-225b10.3	XP_003199668.2	ERGIC_N	15..100	CDD:316374	36/86 (42%)
si:ch211-225b10.3	XP_003199668.2	COPIIcoated_ERV	<171..342	CDD:311775	60/170 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593656
Domainoid	1	1.000	113	1.000	Domainoid score	I6101
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3909
OMA	1	1.010	-	-		QHG52864
OrthoDB	1	1.010	-	-		D1318747at2759
OrthoFinder	1	1.000	-	-		FOG0004385
OrthoInspector	1	1.000	-	-		otm26171
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10984
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.010