DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4293 and SPBC2G5.04c

DIOPT Version :9

Sequence 1:	NP_001033816.1	Gene:	CG4293 / 31001	FlyBaseID:	FBgn0024983	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_596065.1	Gene:	SPBC2G5.04c / 2540311	PomBaseID:	SPBC2G5.04c	Length:	333	Species:	Schizosaccharomyces pombe

Alignment Length:	369	Identity:	95/369 - (25%)
Similarity:	172/369 - (46%)	Gaps:	76/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SNLLEFAKNLDAFKKVPEKY-TETSEIGGTLSLLSRLLIVYLVYTELHYY---WHETDI-VYQFE 71
            :|:..|    |||.|..::| .::|..||..::|..:|||.||:::...|   ..|.:: :|.
pombe     8 ANIRAF----DAFPKFSKEYRRQSSSRGGFFTILLSVLIVVLVFSQCVQYIRGIREQELFIYD-- 66

  Fly    72 PDIALDEQVQMHVDITVAMPCASLSGVDLMDETQQDVFAYGTLQREGVWWEMSEHDRLQFQAIQI 136
               ::.|.:.:::|||:||||::|. :|::|.|:..|.|                    .:|:.:
pombe    67 ---SVSELMDLNIDITIAMPCSNLR-IDVVDRTKDLVLA--------------------TEALTL 107

  Fly   137 QNHYLREEFHSVADVLFKDIMRDNHPARESASKAPAAPPPGALPLSVDLHGRHNVQPESKFDACR 201
            :..::::  ...:..::|:   |.:.....|.             :.....::|.:|.|. .|||
pombe   108 EEAFIKD--MPTSSTIYKN---DRYAGLRWAR-------------TEKFRKKNNAEPGSG-TACR 153

  Fly   202 LHGTLGINKVAGVLHLVGGAQPVVGLFEDHWMIELRRMP---ANFTHRINRLSFGQYSGRIVQPL 263
            ::|.|.:|:|.|.||:....          |......:|   .||||.|..||||:|...:|..|
pombe   154 IYGQLVVNRVNGQLHITAPG----------WGYGRSNIPFHSLNFTHYIEELSFGEYYPALVNAL 208

  Fly   264 EGDEIVIHEEATTVQYFLKVVPTEIHQTFTTIYAFQYAVTEN--VRKLDSERNSYGS--PGIYFK 324
            :|.....::.....||:|.|:||....:|.:....||::|||  ||:|     .:||  |||:..
pombe   209 DGHYGHANDHPFAFQYYLSVLPTSYKSSFRSFETNQYSLTENSVVRQL-----GFGSLPPGIFID 268

  Fly   325 YDWSALKIIVRNDRDHLVTFAIRLCSIISGIIVISGAINALLLS 368
            ||...|.:.|.:...::.:..:|:.:|..|:|.::..|..:..|
pombe   269 YDLEPLAVRVVDKHPNVASTLLRILAISGGLITVASWIERVYSS 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4293	NP_001033816.1	ERGIC_N	19..104	CDD:290561	28/89 (31%)
CG4293	NP_001033816.1	COPIIcoated_ERV	<200..349	CDD:285244	49/155 (32%)
SPBC2G5.04c	NP_596065.1	ERGIC_N	10..100	CDD:290561	30/99 (30%)
SPBC2G5.04c	NP_596065.1	COPIIcoated_ERV	136..306	CDD:285244	56/185 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2322
eggNOG	1	0.900	-	-		E1_COG0445
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6574
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1623
OMA	1	1.010	-	-		QHG52864
OrthoFinder	1	1.000	-	-		FOG0004385
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105529
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5010
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.800