DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elav and elavl3

DIOPT Version :9

Sequence 1:	NP_001245447.1	Gene:	elav / 31000	FlyBaseID:	FBgn0260400	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_009298008.1	Gene:	elavl3 / 30732	ZFINID:	ZDB-GENE-980526-76	Length:	366	Species:	Danio rerio

Alignment Length:	382	Identity:	195/382 - (51%)
Similarity:	251/382 - (65%)	Gaps:	61/382 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 TNGNAGSGSQNG----SNGST-ETRTNLIVNYLPQTMTEDEIRSLFSSVGEIESVKLIRDKSQVY 188
            :||.:|:...||    :||:| :::||||||||||.||::|.:|||.|:|||||.||:|||
Zfish    13 SNGPSGTSLPNGPVISTNGATDDSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDK---- 73

  Fly   189 IDPLNPQAPSKGQSLGYGFVNYVRPQDAEQAVNVLNGLRLQNKTIKVSFARPSSDAIKGANLYVS 253
                     ..||||||||||||.|.||::|:|.||||:||.||||||:|||||.:|:.||||||
Zfish    74 ---------ITGQSLGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVS 129

  Fly   254 GLPKTMTQQELEAIFAPFGAIITSRILQNAGNDTQTKGVGFIRFDKREEATRAIIALNGTTPSSC 318
            ||||||:|:::|.:|:.:|.|||||||.:......::||||||||||.||..||..|||..|...
Zfish   130 GLPKTMSQKDMEQLFSQYGRIITSRILVDQVTAGISRGVGFIRFDKRNEAEEAIKGLNGQKPLGA 194

  Fly   319 TDPIVVKFSNTPG-STSKIIQPQLPAFLNPQLVRRIGGAMHTPVNK------------------G 364
            .:||.|||:|.|. .|.:.:..|    |.....||..|.:|....:                  .
Zfish   195 AEPITVKFANNPSQKTGQALLTQ----LYQTAARRYTGPLHHQTQRFRLDNLLNASYGVKSSLSV 255

  Fly   365 LARFSPMAGDMLDVMLPNGLGAAAAAATTLA----SGPGGA-YPIFIYNLAPETEEAALWQLFGP 424
            |.||||:..|.:               |:||    :||.|| :.||:|||:||.:|:.|||||||
Zfish   256 LPRFSPITIDSM---------------TSLAGVNLTGPTGAGWCIFVYNLSPEADESVLWQLFGP 305

  Fly   425 FGAVQSVKIVKDPTTNQCKGYGFVSMTNYDEAAMAIRALNGYTMGNRVLQVSFKTNK 481
            ||||.:||:::|.|||:|||:|||:|||||||||||.:||||.:|:|||||||||:|
Zfish   306 FGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elav	NP_001245447.1	ELAV_HUD_SF	146..483	CDD:273741	187/360 (52%)
elavl3	XP_009298008.1	ELAV_HUD_SF	35..365	CDD:273741	187/360 (52%)
		RRM1_Hu	37..114	CDD:241094	56/89 (63%)
		RRM_SF	119..209	CDD:302621	49/89 (55%)
		RRM3_HuC	282..366	CDD:241099	57/81 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0145
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55893
OrthoDB	1	1.010	-	-		D425303at33208
OrthoFinder	1	1.000	-	-		FOG0000313
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.890