DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment svr and Cpn1

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	XP_011245709.1	Gene:	Cpn1 / 93721	MGIID:	2135874	Length:	463	Species:	Mus musculus

Alignment Length:	419	Identity:	188/419 - (44%)
Similarity:	252/419 - (60%)	Gaps:	45/419 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 FLTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKY 512
            |:||..:.||.:..:...|..:.:..|.:||||:||:||:||.|:|||....||.|.|..||.||
Mouse    17 FVTPVTFRHHRYDDLVRTLYKVHNQCPDITRLYNIGRSVKGRYLYVLEFSDYPGIHEPLEPEVKY 81

  Fly   513 VANMHGNEVVGKELLLILTKYMLERYGN-DDRITKLVNGTRMHFLYSMNPDGYEISI-------E 569
            |.|||||||:|:||||.|::::.|.:.| :.||.:|:..||:|.|.||||||||::.       |
Mouse    82 VGNMHGNEVLGRELLLQLSEFLCEEFRNRNQRILRLIQDTRIHILPSMNPDGYEVAAAQVHSPRE 146

  Fly   570 GDRTGG--VGRANAHGIDLNRNFPD-----QYGT------------DRFNKVTEPEVAAVMNWTL 615
            |....|  |||.||:|:||||||||     .|.:            |.:....|||..||:.|..
Mouse   147 GPNMSGYLVGRNNANGVDLNRNFPDLNTYFYYNSKNGGPNHHLPLPDNWKSQVEPETRAVIQWIR 211

  Fly   616 SLPFVLSANLHGGSLVANYPFDDN-ENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNA 679
            ||.||||||:|||::|||||:|.: |:.|..|. |..||        ||.|:.||:.||.:||.|
Mouse   212 SLNFVLSANMHGGAVVANYPYDKSLEHRFRGPH-RTSNS--------PTPDDELFQTLAKVYSYA 267

  Fly   680 HPTMYLGQPCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSR 744
            |..|:.|..|    .::|||||||||.|||::.||||:||:...|.|:|:|:.|||||:..||.|
Mouse   268 HGWMHQGWNC----GDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPRQEELQR 328

  Fly   745 YWEDHREPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNL 809
            .|..:||.|:||:||||.||.|.|.......:.|||:.:.|.||...|...|||::|.|||.:::
Mouse   329 EWLGNREALIQFLEQVHQGIKGMVLDENSNNLTGAVISVTGINHDVTSGEHGDYFRLLLPGTYSV 393

  Fly   810 TVLGDNYAPLRMEVEV----PDVHPFEMR 834
            |.....|.|..:.|.|    |.|..|:::
Mouse   394 TAKAPGYDPKTVTVTVGPAGPTVVDFQLK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604
		M14_CP_N-E_like	456..759	CDD:199842	155/330 (47%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	26/76 (34%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Cpn1	XP_011245709.1	Peptidase_M14_like	25..343	CDD:386095	155/330 (47%)
Cpn1	XP_011245709.1	Peptidase_M14NE-CP-C_like	347..421	CDD:200604	26/73 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10946
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11532
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950