DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and Cpz

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	XP_038948430.1	Gene:	Cpz / 83575	RGDID:	620496	Length:	660	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	199/549 - (36%)
Similarity:	271/549 - (49%)	Gaps:	134/549 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PTLGLLFASIGIAVLAMGVPHCRGYTIKEDESFLQQP---------------------------- 38
            |.|.||    |.:|||   |.|:|       ...|:|
  Rat   106 PDLRLL----GCSVLA---PRCQG-------GHTQRPCRRVCEGLREACQPAFDAIDMAWPYFLD 156

  Fly    39 ---HYASQEQ-----LEDLFAGL--EKAYPN------------------------------QAKV 63
               ::|.:|:     ||.|...|  |:|.|:                              .||.
  Rat   157 CTQYFAPEEEGCYDPLEQLRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKT 221

  Fly    64 HFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQ-----YLLGNHE 123
            :.:|||.||::|:.::.|.......|:.|.||.|.|:||:|..||::|:|:||     ||||| .
  Rat   222 YSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGN-P 285

  Fly   124 RISDLGQLVNSTDIYLVPTMNPDGYAL-SQEGNCESLPNY----VGRGNAANIDLNRDFPDRLEQ 183
            ||.   :|:|:|.|:|:|:||||||.: :.||     ..|    .||.||.|:||||:|||.  .
  Rat   286 RIQ---RLLNTTRIHLLPSMNPDGYEVAAAEG-----AGYNGWTSGRQNAQNLDLNRNFPDL--T 340

  Fly   184 SHVHQLRAQSR------------------QPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNS 230
            |..::| |.:|                  .|||.|::.||.:.||||||:.|||.:|.|||:|.|
  Rat   341 SEYYRL-ASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFS 404

  Fly   231 LAHNECCEESLTPDDRVFKQLAHTYSDNHPIM--RKGNNCNDSF--SGGITNGAHWYELSGGMQD 291
            ...:|....|.|||:::||.||..|:|.||:|  |..|.|..:|  .|.|.|||.||..:|||.|
  Rat   405 KHPHEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSD 469

  Fly   292 FNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANV 356
            |||..:||||:|:||.|.|:|....|...||.||..||..|...|.||||:|||..|.|:.:|.:
  Rat   470 FNYLHTNCFEITVELGCVKFPPEEALYGLWQHNKEPLLNFLEMVHRGIKGVVTDKYGKPVKNARI 534

  Fly   357 YVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPVET 421
            .|.|:.. .:.|:..|:|||||.||.:.|.|.|.|| :...::|.:....:.|.|:||.|.|:.|
  Rat   535 LVKGIRH-DVTTAPDGDYWRLLPPGSHIVIAQAPGY-SKVMKRVTIPLRMKRAGRVDFILQPLGT 597

  Fly   422 ---NF-DGNFRKVKVERSEPPQKLKKQFN 446
               || .|..|  .:.||..||....|.:
  Rat   598 GPKNFLPGPSR--ALPRSLDPQGAPAQLD 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	142/362 (39%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	31/77 (40%)
		M14_CP_N-E_like	456..759	CDD:199842
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Cpz	XP_038948430.1	CRD_FZ	51..178	CDD:413323	18/85 (21%)
		M14_CPZ	198..512	CDD:349439	133/325 (41%)
		Peptidase_M14NE-CP-C_like	516..592	CDD:200604	31/77 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10592
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920