DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and aebp1b

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	901	Identity:	211/901 - (23%)
Similarity:	314/901 - (34%)	Gaps:	334/901 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 FSGGITNG---------------------AHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAAS 315
            |:|.||.|                     ..|..|..|..::.: |.|..:.|..||....|..:
Zfish   470 FTGVITQGRDDPLESDYVSTYYVAFSNDSREWTFLHDGYAEWLF-FGNSDKNTPVLSQFMEPVVA 533

  Fly   316 ----TLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWR 376
                .|||.|.......:::|               |.|:.|           |:
Zfish   534 RYIRILPQSWNGTMCMRMEIL---------------GCPVQD-----------PL---------- 562

  Fly   377 LLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKL 441
                   |.|.|                 ..|..|.|        |.|
Zfish   563 -------SQHQS-----------------ENEVTRRD--------NLD----------------- 578

  Fly   442 KKQFNGFLTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPG 506
                        |.|||:..||..:::||...|::||.||:|||.:|.:::.:||...||.|..|
Zfish   579 ------------YTHHNYLDMEKLMKSISDECPNITRFYSLGKSFKGLEIYAMEITDNPGVHETG 631

  Fly   507 VPEFKYVANMHGNEVVGKELLLILTKYMLERY--GNDDRITKLVNGTRMHFLYSMNPDGYEISIE 569
            .|||:|.|..||||.:|:||||:..:|:.:.|  || .|:..||:.||:|.:.|:||||:..:.|
Zfish   632 EPEFRYTAGYHGNEALGRELLLMFMQYLCKEYKDGN-PRVRHLVDETRIHLVPSVNPDGHVKAFE 695

  Fly   570 -GDRTGG--VGRANAHGIDLNRNFPDQYGT--DRFNKVTEP-----------------------E 606
             |...|.  :|.....|.|:.:||||....  |..:|...|                       |
Zfish   696 KGSELGSWTLGHWTEDGHDIFQNFPDLNNIYWDSEDKGMVPKLTPNHHIPIPEGILSSNGSIAME 760

  Fly   607 VAAVMNWTLSLPFVLSANLHGGSLVANYPFD--------------------------DNENDFND 645
            ..|:::|..|.||||.|||.||..:..||||                          :.|.:..:
Zfish   761 TLALISWMESHPFVLGANLQGGEKLVTYPFDMRRLTKESEAMEKKLGSRANRRKRQYEEEEEEPN 825

  Fly   646 PFMRL--RNSSINGRKPN----------------------------------------------- 661
            |::.:  ...|.:|.:.|
Zfish   826 PYLHIGYHQESYSGPQENHAYDHESYGYHQESYGYHHQSQGYHEETQGYHDETQGYHNENQGYHN 890

  Fly   662 -----------------------------------------------PTEDNALFKHLAGIYSNA 679
                                                           ..||.:||:.||..|::.
Zfish   891 ENQGYHNENQRYHHEGYSEGYNEGYQEGYPEGYRGGYGEGEQEEEIRMVEDQSLFRWLAISYAST 955

  Fly   680 HPTMYLGQPCELFQNEFFPD------GITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPK 738
            |.||     .:.:|.....|      ||.|.|:|..:.|.|.|::|:...|.||::.:||||||.
Zfish   956 HRTM-----TQSYQRGCHSDDPTGGMGIVNRAKWKPIPGSMDDFSYLHTNCFELSVFLGCDKFPH 1015

  Fly   739 AAELSRYWEDHREPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLAL 803
            .:||.|.||.:||.||.|:.|||.||.|.|....|.||..|.|.::|.||...:...||||:|..
Zfish  1016 QSELLREWEHNREALLTFMAQVHRGIKGVVRDNEGNPITNATVSVEGVNHDVKTGEAGDYWRLLN 1080

  Fly   804 PGRHNLTVLGDNYAPL-RMEVEVPDVHPFEMRMDITLMPDDPQHWASANDFRIIENVVNTRYHTN 867
            ||.:.:|...:.|:|. |:.|...|........|:     :..:|........:        |.|
Zfish  1081 PGEYRVTARAEGYSPFTRLCVVGFDPGATLCNFDL-----NKSNWDRIKQIMAL--------HGN 1132

  Fly   868 PQVRARLAELENQNGQIASFGYADSEFGTIFNYLKMTSDIGEPEEHKYKLLVVSSLYDTTAPLGR 932
            ..:  ||....::||              :.:|           .|....:.||:..|.:....|
Zfish  1133 KPI--RLLSSGSRNG--------------VRHY-----------SHSSNQIPVSNSGDMSRARLR 1170

  Fly   933 EILLNLIRHLVEGFKLQDTSVVELLKRSVIYFLPQTSKFQNVF-----DMYNSNTS 983
            .:.|..||.|.:. :|....::..........||.|::...|:     :::..||:
Zfish  1171 RLRLMRIRRLRQQ-RLLAQKIIPTTTTVTTTSLPTTAETTTVWYDSLPEIFEENTT 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	19/86 (22%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	10/77 (13%)
		M14_CP_N-E_like	456..759	CDD:199842	126/460 (27%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	26/76 (34%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
aebp1b	XP_696022.6	Ig	56..147	CDD:299845
		IG_like	62..145	CDD:214653
		FA58C	402..555	CDD:238014	19/100 (19%)
		FA58C	403..556	CDD:214572	19/101 (19%)
		Peptidase_M14_like	577..1036	CDD:299699	128/493 (26%)
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604	25/74 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10537
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920