DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and Cpxm1

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_062670.2	Gene:	Cpxm1 / 56264	MGIID:	1934569	Length:	722	Species:	Mus musculus

Alignment Length:	741	Identity:	215/741 - (29%)
Similarity:	319/741 - (43%)	Gaps:	175/741 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 VHQLRAQSRQPETAALVNWIVSKPFVLSANFHGGAV-VASYPYDNSLAHNECCEESLTPDDRVFK 249
            :..||....|.|.::      |:.|.|.|  |.|.: :.|...|..|.....|.|.
Mouse   110 LESLRVSDSQLEASS------SQSFGLGA--HRGRLNIQSGLEDGDLYDGAWCAEQ--------- 157

  Fly   250 QLAHTYSDNHPIMRKGNNCNDSFSGGITNGAH--W-YELSGGMQDFNYAFSNCFELTIELSCCKY 311
                  .|..|.::........|:|.:|.|.:  | |:   .:..|...|||.
Mouse   158 ------QDTEPWLQVDAKNPVRFAGIVTQGRNSVWRYD---WVTSFKVQFSND------------ 201

  Fly   312 PAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPI-----ADANVYVAGLEEKPMRTSKR 371
                  .|.|.:::                   :::|..|     :||...|..|..:|    :.
Mouse   202 ------SQTWWKSR-------------------NSTGMDIVFPANSDAETPVLNLLPEP----QV 237

  Fly   372 GEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSE 436
            ..:.||| |..:        :|..||           .||.:....||               |:
Mouse   238 ARFIRLL-PQTW--------FQGGAP-----------CLRAEILACPV---------------SD 267

  Fly   437 PPQKLKKQFN-GFLTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATP 500
            |.....:... |......:.|||:.||...::.::...|::||:||||||.||..|:|:|:...|
Mouse   268 PNDLFPEAHTLGSSNSLDFRHHNYKAMRKLMKQVNEQCPNITRIYSIGKSHQGLKLYVMEMSDHP 332

  Fly   501 GSHVPGVPEFKYVANMHGNEVVGKELLLILTKYMLERY-GNDDRITKLVNGTRMHFLYSMNPDGY 564
            |.|..|.||.:|||.|||||.:|:||||:|.:::...: ..|.|:|:|:..||:|.|.|||||||
Mouse   333 GEHELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGDPRVTRLLTETRIHLLPSMNPDGY 397

  Fly   565 EISI-EGDRTGG--VGRANAHGIDLNRNFPD-----QYGTDRF--------------------NK 601
            |.:. .|....|  .||....|||||.||.|     .|..|..                    |.
Mouse   398 ETAYHRGSELVGWAEGRWTHQGIDLNHNFADLNTQLWYAEDDGLVPDTVPNHHLPLPTYYTLPNA 462

  Fly   602 VTEPEVAAVMNWTLSLPFVLSANLHGGSLVANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDN 666
            ...||..||:.|...:|||||||||||.||.:||||            :..:....|:..||.|:
Mouse   463 TVAPETWAVIKWMKRIPFVLSANLHGGELVVSYPFD------------MTRTPWAARELTPTPDD 515

  Fly   667 ALFKHLAGIYSNAHPTMY--LGQPCELFQNEFFPDG-ITNGAQWYSVTGGMQDWNYVRAGCLELT 728
            |:|:.|:.:|:..:..|.  ..:||.  ..:|...| :.|||.|::|.|.|.|::|:...|.|:|
Mouse   516 AVFRWLSTVYAGTNRAMQDTDRRPCH--SQDFSLHGNVINGADWHTVPGSMNDFSYLHTNCFEVT 578

  Fly   729 IEMGCDKFPKAAELSRYWEDHREPLLQFIEQVHCGIHGFVH---STIGTPIAGAVVRLDGANHST 790
            :|:.|||||...||.:.||::::.||.::|||..||.|.|.   :.:|  ||.||:.::|.||..
Mouse   579 VELSCDKFPHEKELPQEWENNKDALLTYLEQVRMGITGVVRDKDTELG--IADAVIAVEGINHDV 641

  Fly   791 YSQVFGDYWKLALPGRHNLTVLGDNYAPLRMEVEVP-DVHPFEMRMDITLMPDDPQHWASANDFR 854
            .:...||||:|..||.:.:|...:.|..:|...:|. :..|......:|..|.:.
Mouse   642 TTAWGGDYWRLLTPGDYVVTASAEGYHTVRQHCQVTFEEGPVPCNFLLTKTPKER---------- 696

  Fly   855 IIENVVNTRYHTNPQVRARLAELENQ 880
             :..::.||....|.:|.:|..|..|
Mouse   697 -LRELLATRGKLPPDLRRKLERLRGQ 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	29/151 (19%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	16/82 (20%)
		M14_CP_N-E_like	456..759	CDD:199842	129/334 (39%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	24/79 (30%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Cpxm1	NP_062670.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..54
		FA58C	106..262	CDD:238014	45/238 (19%)
		FA58C	107..263	CDD:214572	45/239 (19%)
		M14_CPX_like	284..609	CDD:199851	129/338 (38%)
		Peptidase_M14NE-CP-C_like	613..689	CDD:200604	24/77 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10282
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910