DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and cpdb

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_001315329.1	Gene:	cpdb / 555848	ZFINID:	ZDB-GENE-060929-1270	Length:	1275	Species:	Danio rerio

Alignment Length:	1339	Identity:	379/1339 - (28%)
Similarity:	613/1339 - (45%)	Gaps:	250/1339 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VLAMGVPHCRGYTIK----------EDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRS 69
            :|.:.|||.....::          .:|::....:||   ::.|...|..:.:|....:..:|:|
Zfish     3 ILWLIVPHILTLPLQILALRRTNKVNEETYRGYYNYA---EMTDRLKGFSRKFPRICSLASIGQS 64

  Fly    70 LEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNS 134
            :|.|.|..::|:.|........|.|||:.|:||||.:.||:|||:.:|||..:.|...:.:||:.
Zfish    65 VEDRELWVMRITSNPTQDVPGKPKVKYVGNIHGDEALSRQVLVYLVEYLLTRYGRDVRVTELVDR 129

  Fly   135 TDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQSHVHQLRAQSRQPETA 199
            ||||::.:|||||:..:.||.|.....  .|.||.|.|||:.||.:.|.|.    ......||..
Zfish   130 TDIYILASMNPDGFERALEGECSGTTE--ARDNAKNYDLNKSFPVQDEPSS----ETAGDIPEVM 188

  Fly   200 ALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRK 264
            |::.||..:.||||.:.|||:|:||||:::..::..      :.||.:|:.||..|.:|||:|..
Zfish   189 AVIRWIQERKFVLSGSLHGGSVMASYPFEDDSSYTR------SGDDALFRNLAQAYIENHPVMGT 247

  Fly   265 GN-NCND--SFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKA 326
            .| :|.|  :.|.|          .|.|||:||...||||::.||||||||.||.|..||..|:.
Zfish   248 NNADCPDDPNKSSG----------EGSMQDYNYLKGNCFEVSFELSCCKYPPASQLYTEWSNNRE 302

  Fly   327 SLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFG 391
            :||..:::||||::|.|.:.||..:.||.:.|:|::.. :.|.|.|:|:|||.||.|.:.||:.|
Zfish   303 ALLAFIQKAHIGVRGFVLNKSGLGLPDATISVSGIDHN-ITTWKFGDYYRLLLPGKYDITASSPG 366

  Fly   392 YQTSAPQQVRVTNDN------------QEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQ 444
            |.::....|.|.:..            :|.|.||....|:.|:.|.|.....:.:| |.|.|
Zfish   367 YLSNTVMNVPVIDGRVMLVNFTLEEPLEEMLMLDTFGQPIITHQDLNTPAPPISKS-PIQTL--- 427

  Fly   445 FNGFLTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPE 509
                    .:.:|.:..:|::|:..|:.:|.:|.|.|.|:|||.|:|:|:||..:||....|.||
Zfish   428 --------DFRYHTYDELETFLQLFSAVHPFITSLKSAGRSVQDRNLYVMEISTSPGVEQQGKPE 484

  Fly   510 FKYVANMHGNEVVGKELLLILTKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEISIEGDR-- 572
            ..:|.|:||||.:|.|:||.|.:|:...||.|..:|:|||.||:|.:.||||||||::::..:
Zfish   485 VLFVGNLHGNEFIGCEILLNLIEYLCRNYGKDPLVTRLVNSTRIHIMPSMNPDGYELALKAQKEQ 549

  Fly   573 -TGG---VGRANAHGIDLNRNFPDQYGTDRFNKVTEPEVAAVMNWTLSLPFVLSANLHGGSLVAN 633
             :|.   :|..|:|.:|||.|||:   ..|.....|.|..||:||..:..|||:|::.||.....
Zfish   550 LSGDPSIIGHGNSHRVDLNTNFPE---VSRSRNSVEAETKAVINWIKAHFFVLTASIRGGFRGIV 611

  Fly   634 YPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMYLGQPCELFQNEFFP 698
            :|     |.. ||.                 |.::||.:|..|..........|.|::.:.:
Zfish   612 FP-----NSL-DPV-----------------DESMFKSVADAYYMESQAFQEPQTCDVPKTK--- 650

  Fly   699 DGITNGAQWYS--VTG-GMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQFIEQV 760
              ...|.:.:.  |.| .:..|.|..:..|.:.|.:.|:..|....||.|||.:.:.||||::||
Zfish   651 --QKRGLKHHRPVVRGTDILTWAYRGSDTLAVNIGLSCELLPPEKSLSVYWEKNHKALLQFMQQV 713

  Fly   761 HCGIHGFV-HSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAPLRMEVE 824
            |..:.|.| ....|..||.|.|.::|:.|...:...|.||:...||.:::|.....|.|:.:.|.
Zfish   714 HLSVRGVVTDGNSGRGIANATVMVEGSKHLVRTSGTGQYWRPLAPGSYHITASAPGYTPVSVSVR 778

  Fly   825 VPD--VHPFEMRMDITLMPDDPQHWASANDFRIIENVVNTRYHTNPQVRARLAELENQNGQIASF 887
            |.:  |...::::...:....|:. ....||..:..::......|..||:.|..   |..|..::
Zfish   779 VLETRVEQVDIKLTRDVSQSSPEE-GKQKDFEKLVELLLVPGALNQLVRSLLPA---QTLQYRTY 839

  Fly   888 GYADSEF--GTIFNY--------------------LKMTSDIGEPEEHKYKLLVVSSLYDTTAPL 930
             ...|||  |..||:                    |:::.::|.|:..:.|:..|:.::...| :
Zfish   840 -RERSEFLRGLAFNFPRITRLHSLGQSAEFRTLWALEISGNVGIPQLSEPKIRFVAGVHGNAA-V 902

  Fly   931 GREILLNLIRHLVEGFKLQDTSVVELLKRSVIYFLPQTSKFQNVFDMYNSNTSICDP------VL 989
            |.|:||.....|...:. ::|::.:|:.||.|..||..    |......::..:|..      .:
Zfish   903 GPELLLEFASVLCLNYG-RNTAITKLIDRSRIMILPCV----NPDGREQAHEGLCSSSVGFANAI 962

  Fly   990 GDELAERILG------PETDQAKDVFLQFLRSERFDLMLTFGAGNSDLNYP--------KGDSVL 1040
            |.:|....|.      |||....|:    :.:..|.|.:....|:....||        |.:..|
Zfish   963 GVDLDTNFLSSNASVQPETRAVMDL----ISTGGFSLSVVLDGGSLVATYPYDKSNQHAKNEETL 1023

  Fly  1041 -----------------------------------VKF-AHRMQRTEFNYSPLQCPPSATRQLHR 1069
                                               ..| ||.....:|:.....||
Zfish  1024 RYLASLYAGNHPFMHLGNVGCSEKSVEIPGGILKGADFNAHTGSMKDFSLDVGVCP--------- 1079

  Fly  1070 ETTERLTNMMYRIYNLPVYTLGISCCRMPHQKKIASVWRKNIDKIKNFLALVKTGVSGLVQNDKG 1134
                          .:.|||   .||..|...::.::|.:|...:...|..|...:||:|::.||
Zfish  1080 --------------EITVYT---GCCMFPPDTQLFAMWMENRLPLFRMLLEVHRRLSGVVRDSKG 1127

  Fly  1135 QPLREAYVRLLEHDRIINVTKNV-----ARFQLMLPHGLYGLEVTAPNYESQMIKVDVEDGRVTE 1194
            ||:.:|.:       ::|.:.:|     ..|..::..|.:.|:|.|..|:.::.:|.|...||:.
Zfish  1128 QPVPDAVI-------VVNGSLSVRADSQGHFSALVAPGTHQLQVQAHGYQQELQQVIVSSDRVSS 1185

  Fly  1195 LGIIRMHPFTL----IRGVVLELPNNDNRATTSIAGVVL 1229
            ..:|   .||.    :..|||.:      ||.::..|::
Zfish  1186 PIVI---DFTADSSPLSHVVLVI------ATATLMSVLI 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	113/296 (38%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	29/89 (33%)
		M14_CP_N-E_like	456..759	CDD:199842	104/311 (33%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	20/78 (26%)
		CarbopepD_reg_2	1125..1202	CDD:290434	21/81 (26%)
		CarboxypepD_reg	1223..1301	CDD:290350	1/7 (14%)
cpdb	NP_001315329.1	Peptidase_M14_like	35..310	CDD:299699	113/299 (38%)
		Peptidase_M14NE-CP-C_like	314..389	CDD:200604	25/75 (33%)
		Peptidase_M14_like	431..712	CDD:299699	104/311 (33%)
		Peptidase_M14NE-CP-C_like	717..791	CDD:200604	20/73 (27%)
		Peptidase_M14_like	835..1113	CDD:299699	56/314 (18%)
		Peptidase_M14NE-CP-C_like	1120..1192	CDD:200604	20/81 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594186
Domainoid	1	1.000	60	1.000	Domainoid score	I10537
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I630
OMA	1	1.010	-	-		QHG50157
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25794
orthoMCL	1	0.900	-	-		OOG6_104026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.710