DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment svr and cpm

DIOPT Version :9

Sequence 1:NP_001284744.1 Gene:svr / 30998 FlyBaseID:FBgn0004648 Length:1439 Species:Drosophila melanogaster
Sequence 2:XP_012814387.2 Gene:cpm / 496721 XenbaseID:XB-GENE-991713 Length:461 Species:Xenopus tropicalis


Alignment Length:481 Identity:191/481 - (39%)
Similarity:270/481 - (56%) Gaps:60/481 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   416 LAPVETNFDGNFRKVKV---ERSEPPQKLK---KQ-----FNGFLTPT----KYEHHNFTAMESY 465
            :|.:|:|......|.:|   |.:..|.|:.   ||     |...:||.    .:.:||..|:|:|
 Frog    13 VAKLESNSGPLHNKAEVLTNELTVLPTKVSVILKQVVICCFLLGVTPVLCTLDFNYHNNKAVENY 77

  Fly   466 LRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVANMHGNEVVGKELLLIL 530
            |:.|:::|.|:|.|:|||.||.|..||||.|...|..|:.|:||.|||||||||||||:||:|.|
 Frog    78 LKDINNNYSSITYLHSIGSSVAGNQLWVLVIGLYPSQHMIGIPEMKYVANMHGNEVVGRELMLHL 142

  Fly   531 TKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEISIEGDRTGGVGRANAHGIDLNRNFPDQYG 595
            .:|::..|..|..|::|:|.||:|.:.||||||:|.|.. |..|.|||.|.:|.||||||||.:.
 Frog   143 IEYLVTSYKTDVVISQLINNTRIHIMPSMNPDGFEASAV-DCYGIVGRLNKNGYDLNRNFPDAFN 206

  Fly   596 TDRFNKVTEPEVAAVMNWTLSLPFVLSANLHGGSLVANYPFDDNENDFNDPFMRLRNSSINGRKP 660
            .:  ....:||..|||:|..|..||||||.|||::||:||:|:.            |:..||..|
 Frog   207 LN--PDPIQPETKAVMDWIKSETFVLSANFHGGAVVASYPYDNG------------NAENNGITP 257

  Fly   661 NPTEDNALFKHLAGIYSNAHPTMYLGQPCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCL 725
                |..:||:||.:|:..|..||.|..|....:  ||.|||||.|||.|.|||||:|||...|.
 Frog   258 ----DEDVFKYLATLYATKHANMYQGIQCPGMNS--FPAGITNGYQWYPVRGGMQDYNYVYGQCY 316

  Fly   726 ELTIEMGCDKFPKAAELSRYWEDHREPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANH-- 788
            |:|||:.|.|:|..:.||::|.|::..|:::|:|:|.||.|.|....|.||..|:|.:....|  
 Frog   317 EITIELSCCKYPDESTLSQFWSDNKVSLIEYIKQIHMGIKGRVFDLEGNPIPNAIVEVKDRKHIQ 381

  Fly   789 --STYSQVFGDYWKLALPGRHNLTVLGDNYAPLRMEVEVPDVHPFEMRMDITLMPDDPQHWASAN 851
              :|.|  .|:|:.|..||.:...:.....:.|:             .:|||   ::...:|:..
 Frog   382 PYTTNS--IGEYYHLLTPGSYTFNISAAGVSLLQ-------------TVDIT---NNKNLYATKY 428

  Fly   852 DFRIIENVVNTRYHTNPQVRARLAEL 877
            ||.|  ||..:..:::.||...|:.|
 Frog   429 DFSI--NVSASSANSHLQVYTLLSIL 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
svrNP_001284744.1 M14_CPD_I 40..334 CDD:199850
Peptidase_M14NE-CP-C_like 338..416 CDD:200604 191/481 (40%)
M14_CP_N-E_like 456..759 CDD:199842 145/302 (48%)
Peptidase_M14NE-CP-C_like 763..839 CDD:200604 20/79 (25%)
CarbopepD_reg_2 1125..1202 CDD:290434
CarboxypepD_reg 1223..1301 CDD:290350
cpmXP_012814387.2 Peptidase_M14_like 68..350 CDD:416253 145/302 (48%)
Peptidase_M14NE-CP-C_like 354..432 CDD:200604 24/95 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101221at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3496
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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