DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and Cpn1

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_445978.1	Gene:	Cpn1 / 365466	RGDID:	70931	Length:	457	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	188/417 - (45%)
Similarity:	256/417 - (61%)	Gaps:	39/417 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 FLTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKY 512
            |:||..:.||.:..:...|..:.:..|.:||||:||:||:||.|:|||....||:|.|..||.||
  Rat    17 FVTPVTFRHHRYDDLVRTLYKVHNQCPDITRLYNIGRSVKGRYLYVLEFSDYPGTHEPLEPEVKY 81

  Fly   513 VANMHGNEVVGKELLLILTKYMLERYGN-DDRITKLVNGTRMHFLYSMNPDGYEI-SIEGDRTGG 575
            |.|||||||:|:||||.|::::.|.:.| :.||.:|:..||:|.|.||||||||: :.:|..|.|
  Rat    82 VGNMHGNEVLGRELLLQLSEFLCEEFRNRNQRILRLIQDTRIHILPSMNPDGYEVAAAQGPNTSG 146

  Fly   576 --VGRANAHGIDLNRNFPD---------QYG--------TDRFNKVTEPEVAAVMNWTLSLPFVL 621
              |||.||:|:||||||||         :||        .|.:....|||..||:.|..||.|||
  Rat   147 YLVGRNNANGVDLNRNFPDLNTYFYYNSKYGGPNHHLPLPDNWKSQVEPETRAVIQWIRSLNFVL 211

  Fly   622 SANLHGGSLVANYPFDDN-ENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMYL 685
            |||:|||::|||||:|.: |:.|..|. |..||        ||.|:.||:.||.:||.||..|:.
  Rat   212 SANMHGGAVVANYPYDKSLEHRFRSPH-RTSNS--------PTPDDELFQTLAKVYSYAHGWMHQ 267

  Fly   686 GQPCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHR 750
            |..|    .::|||||||||.|||::.||||:||:...|.|:|:|:.|:|||:..||.|.|..:|
  Rat   268 GWNC----GDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCNKFPRQEELQREWLGNR 328

  Fly   751 EPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDN 815
            |.|:||:||||.||.|.|.......:.|||:.:.|.||...|...|||::|.|||.:::|.....
  Rat   329 EALIQFLEQVHQGIKGMVLDENYNNLTGAVISVTGINHDVTSGEHGDYFRLLLPGTYSVTAKASG 393

  Fly   816 YAPLRMEVEV----PDVHPFEMRMDIT 838
            |.|..:.|.|    |.:..|:::...|
  Rat   394 YEPKTVTVTVGPAGPTLVDFQLKRSTT 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604
		M14_CP_N-E_like	456..759	CDD:199842	155/324 (48%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	26/80 (33%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Cpn1	NP_445978.1	Catalytic. /evidence=ECO:0000250	21..340		158/331 (48%)
		Peptidase_M14_like	25..337	CDD:416253	155/324 (48%)
		Peptidase_M14NE-CP-C_like	341..415	CDD:200604	25/73 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..457		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10592
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11532
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920