DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and Cpxm1

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_001099981.1	Gene:	Cpxm1 / 296156	RGDID:	1306937	Length:	722	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	233/842 - (27%)
Similarity:	349/842 - (41%)	Gaps:	209/842 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 NLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYL-----VPTMNPDG 147
            ::..|..|  ||...::.| |..::...:.::...:::...|.||.:..:..     .||: |:
  Rat    40 SIAQPSTK--ANETSEQHV-RLRVIKKKKIVVKKRKKLRQPGPLVTARPLVTTHPAKTPTL-PE- 99

  Fly   148 YALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQSHVHQLRAQSRQPETAALVNWIVSKPFVL 212
               .||..|..|                         .:..||....|.|.::      |:.|.|
  Rat   100 ---KQEPGCPPL-------------------------GLESLRVSDSQLEASS------SQSFGL 130

  Fly   213 SANFHGGAV-VASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGI 276
            ..  |.|.: :.|...|..|.....|.|.               .||.|.::........|||.:
  Rat   131 GP--HRGRLNIQSGLEDGDLYDGAWCAEQ---------------QDNEPWLQVDARSPARFSGIV 178

  Fly   277 TNGAH--W-YELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEW--QRNKASLLQLLRQAH 336
            |.|.:  | |:   .:..|...|||.                  .|.|  .||.:.:..:
  Rat   179 TQGRNSVWRYD---WVTSFKVQFSND------------------SQSWWMSRNSSGMDMV----- 217

  Fly   337 IGIKGLVTDASGFPI-ADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQV 400
                        ||. :||...|..|..:|    :...:.||| |..:        :|..||
  Rat   218 ------------FPANSDAETPVLNLLPEP----QVARFIRLL-PQTW--------FQGGAP--- 254

  Fly   401 RVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQFN-GFLTPTKYEHHNFTAMES 464
                    .||.:....||               |:|.....:... |......:.|||:.||..
  Rat   255 --------CLRAEILACPV---------------SDPNDLFPEAHTLGSSDSLDFRHHNYKAMRK 296

  Fly   465 YLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVANMHGNEVVGKELLLI 529
            .::.::...|::||:||||||.||..|:|:|:...||.|..|.||.:|||.|||||.:|:||||:
  Rat   297 LMKEVNEQCPNITRIYSIGKSHQGLKLYVMEMSDHPGEHELGEPEVRYVAGMHGNEALGRELLLL 361

  Fly   530 LTKYMLERY-GNDDRITKLVNGTRMHFLYSMNPDGYEISI-EGDRTGG--VGRANAHGIDLNRNF 590
            |.:::...: ..|.|:|:|:..||:|.|.||||||||.:. :|....|  .||....|||||.||
  Rat   362 LMQFLCREFLRGDPRVTRLLTETRIHLLPSMNPDGYETAYHKGSELVGWAEGRWTHQGIDLNHNF 426

  Fly   591 PD-----QYGTDRF--------------------NKVTEPEVAAVMNWTLSLPFVLSANLHGGSL 630
            .|     .|..|..                    |....||..||:.|...:|||||||||||.|
  Rat   427 ADLNTQLWYAEDDGLVPHTVPNHHLPLPTYYTLPNATVAPETWAVIKWMKRIPFVLSANLHGGEL 491

  Fly   631 VANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMY--LGQPCELFQ 693
            |.:||||            :..:....|:..||.|:|:|:.|:.:|:..:..|.  ..:||.  .
  Rat   492 VVSYPFD------------MTRTPWAARELTPTPDDAVFRWLSTVYAGTNRAMQDTDRRPCH--S 542

  Fly   694 NEFFPDG-ITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQFI 757
            .:|...| :.|||.|::|.|.|.|::|:...|.|:|:|:.|||||...||.:.||::::.||.::
  Rat   543 QDFSLHGNVINGADWHTVPGSMNDFSYLHTNCFEVTVELSCDKFPHEKELPQEWENNKDALLTYL 607

  Fly   758 EQVHCGIHGFVH---STIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAPL 819
            |||..||.|.|.   :.:|  ||.||:.::|.||...:...||||:|..||.:.:|...:.|...
  Rat   608 EQVRMGITGVVRDKDTELG--IADAVIAVEGINHDVTTAWGGDYWRLLTPGDYVVTASAEGYHTA 670

  Fly   820 RMEVEVP-DVHPFEMRMDITLMPDDPQHWASANDFRIIENVVNTRYHTNPQVRARLAELENQ 880
            :....|. :..|......:|..|..          |::| ::.......|.:|.:|..|..|
  Rat   671 KQHCRVTFEEGPVPCNFLLTKTPKQ----------RLLE-LLAAGAKLPPDLRRKLEWLRGQ 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	48/256 (19%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	16/78 (21%)
		M14_CP_N-E_like	456..759	CDD:199842	129/334 (39%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	23/79 (29%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Cpxm1	NP_001099981.1	FA58C	106..262	CDD:238014	49/265 (18%)
		FA58C	107..263	CDD:214572	49/265 (18%)
		M14_CPX_like	284..609	CDD:199851	129/338 (38%)
		Peptidase_M14NE-CP-C_like	613..689	CDD:200604	23/77 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10067
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920