Protein Alignment svr and Cpd

DIOPT Version :10

• Sequence 1: NP_996319.1
• Gene: svr / 30998
• FlyBaseID: FBgn0004648
• Length: 1439
• Species: Drosophila melanogaster
• Sequence 2: NP_036968.1
• Gene: Cpd / 25306
• RGDID: 2393
• Length: 1378
• Species: Rattus norvegicus
• Alignment Length: 1480
• Identity: 488/1480 - (32%)
• Similarity: 699/1480 - (47%)
• Gaps: 297/1480 - (20%)

  Fly    36 QQPHYASQEQL-EDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPP------ 93
            |..||..:..| |.|.|......|..|::..:|.|:|||.|..|:::..      |.||
  Rat    59 QFDHYYHEAALGEALEAAAAAGPPGLARLFSIGNSVEGRPLWVLRLTAG------LGPPPTPAAV 117

  Fly    94 --------------VKYIANMHGDETVGRQLLVYMAQYLLGNHERISD--LGQLVNSTDIYLVPT 142
                          ||.:.||||||||.||:|||:|:.|...:.| .|  |.:|:|:||:||:|:
  Rat   118 GLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRR-GDPRLVRLLNTTDVYLLPS 181

  Fly   143 MNPDGYALSQEGNC----ESLPNYVGRGNAANIDLNRDFPDRLEQSHVHQLRAQSRQPETAALVN 203
            :||||:..::||:|    ...|...||.|:...||||.|||:........|   ...||..||::
  Rat   182 LNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSL---DEVPEVRALID 243

  Fly   204 WIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGN-N 267
            ||....||||.|.|||:||||||:|:|..|......|.|.||.||:.||..|:.||||||.|. :
  Rat   244 WIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTGIYSKTSDDEVFRYLAKAYASNHPIMRTGEPH 308

  Fly   268 C----NDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASL 328
            |    .::|..|||||||||::.|||||:||.::||||:|:||||||||.||.|.|||:.|:.||
  Rat   309 CPGDEEETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESL 373

  Fly   329 LQLLRQAHIGIKGLVTDA-SGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGY 392
            :.|:.:.||||||.|.|: :|..:.:|.:.|||:... :.|.:.|::.|||.||.|::.|.:.||
  Rat   374 ITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHN-ITTGRFGDFHRLLIPGSYNLTAVSPGY 437

  Fly   393 QTSAPQQVRVTNDNQEALRLDFKLAPV-------ETNFDGNFRKVKVERSEPPQKLKKQFNGFLT 450
            .......:.|...  .|..:||.|.|.       .|........|.|....|......|   .:.
  Rat   438 MPLTINNIVVKEG--PATEIDFSLQPTVMSVVPDSTEAVTTPGTVAVPNIPPGTPSSHQ---PIQ 497

  Fly   451 PTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVAN 515
            |..:.||:|..||.:||..::.||::|||||:||||:.|:|:|:||...||.|.||.|||||:.|
  Rat   498 PKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGN 562

  Fly   516 MHGNEVVGKELLLILTKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEISIEGDRTGGVGRAN 580
            ||||||||:||||.|.:|:.:.:|.|..:|.||..||:|.:.||||||||.|.|||....|||.|
  Rat   563 MHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVRSTRIHLMPSMNPDGYEKSQEGDSISVVGRNN 627

  Fly   581 AHGIDLNRNFPDQYG--TDRFNKVTEPEVAAVMNWTLSLPFVLSANLHGGSLVANYPFDDNENDF 643
            ::..|||||||||:.  ||    .|:||..|||:|..:.||||||||||||||.|||:||||
  Rat   628 SNNFDLNRNFPDQFVPITD----PTQPETIAVMSWVKAYPFVLSANLHGGSLVVNYPYDDNE--- 685

  Fly   644 NDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMYLGQPC-ELFQNEFFPDGITNGAQW 707
                   :..:...:.|    |:|:|:.:|..||..:..|:.|:|| :::.||:||.||||||.|
  Rat   686 -------QGVATYSKSP----DDAVFQQIALSYSKENSQMFQGRPCKDMYLNEYFPHGITNGASW 739

  Fly   708 YSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQFIEQVHCGIHGFV-HST 771
            |:|.||||||||::..|.|:|||:||.|:|...||.:|||.:|..|:||::|||.|:.||| .:|
  Rat   740 YNVPGGMQDWNYLQTNCFEVTIELGCVKYPFEKELPKYWEQNRRSLIQFMKQVHQGVKGFVLDAT 804

  Fly   772 IGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAPLRMEVEVPDVHPFEMRMD 836
            .|..|..|.:.:...||...:...||||:|.:||.:.:|.....|.|:...|.|......::...
  Rat   805 DGRGILNATLSVAEINHPVTTYKAGDYWRLLVPGTYKITASARGYNPVTKNVTVRSEGAIQVNFT 869

  Fly   837 ITLMPDDPQ--------HWASANDFRIIENVVNTRYHTNPQVRARLAELENQNG----------Q 883
            :.....|..        |..|.:|         |...|:.:..|.:..|..:||          .
  Rat   870 LVRSSTDANNESKKGKGHSTSTDD---------TSDPTSKEFEALIKHLSAENGLEGFMLSSSSD 925

  Fly   884 IASFGYAD----SEF--GTIFNYLKMTS----------------------DIGEPEEHKYKLLVV 920
            :|.:.|..    |||  |.:.||..:|:                      :|.||||.|.:.  |
  Rat   926 LALYRYHSYKDLSEFLRGLVMNYPHITNLTTLGQSVEYRHIWSLEISNKPNISEPEEPKIRF--V 988

  Fly   921 SSLYDTTAPLGREILLNLIRHLVEGFKLQDTSVVELLKRSVIYFLPQ--------------TSKF 971
            :.::. .||:|.|:||.|...|...:| ::..|.:|:.|:.|..:|.              |||
  Rat   989 AGIHG-NAPVGTELLLALAEFLCLNYK-KNPVVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSK- 1050

  Fly   972 QNVFDMYNSNTSICDPVLGDELAERILGPETDQAKDVFLQFLRSERFDLMLTFGAGNSDLNYPKG 1036
                   ..:|:.....|..:.......|||   |.:....::.:.|.|.:....|:..:.||..
  Rat  1051 -------TGHTNARGRDLDTDFTSNASQPET---KAIIENLIQKQDFSLSIALDGGSVLVTYPYD 1105

  Fly  1037 DSVLV-----KFAHRMQRTEFNYSPL-----QCPPSATRQL------HRETTERLTNMM-YRIY- 1083
            ..|..     ...|.......|:..:     .||.::...:      ..|....|.:|. |.:.
  Rat  1106 KPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNNSDENIPGGVMRGAEWHSHLGSMKDYSVTY 1170

  Fly  1084 -NLPVYTLGISCCRMPHQKKIASVWRKNIDKIKNFLALVKTGVSGLVQNDKGQPLREAYVRLLEH 1147
             :.|..|:..|||..|...::.::|.:|...:.:.|..|..||.|||::..|:|:.:|.:.|.|.
  Rat  1171 GHCPEITVYTSCCYFPSAAQLPALWAENKKSLLSMLVEVHKGVHGLVKDKTGKPISKAVIVLNEG 1235

  Fly  1148 DRIINVTKNVARFQLMLPHGLYGLEVTAPNYESQMIKVDVEDGRVTELGIIRMHPFTLIRGVVLE 1212
            .|:  .||....|.::|..|::.:...|..|:.|..:|.|.
  Rat  1236 IRV--HTKEGGYFHVLLAPGVHNINAIADGYQQQHSQVFVH------------------------ 1274

  Fly  1213 LPNNDNRATTSIAGVVLDESNHPVRNAKVSVVGQTQLRNFTGSMGQYRISAVPLGTITLKVEAPR 1277
                 :.|.:|:. :|.|..|
  Rat  1275 -----HDAASSVV-IVFDTDN-------------------------------------------- 1289

  Fly  1278 HLEATRQMHLIQGGLATENVVFHLKVNEHVFGLPRFLFILCA----SVLIIVGVIVCVLCA---- 1334
                                        .:|||||.|.:..:    |.||:...|:..:|:
  Rat  1290 ----------------------------RIFGLPRELVVTVSGATMSALILTACIIWCICSIKSN 1326

  Fly  1335 --QFWFYRRHRGDKPYYNFSLLPQRG--KEQFGLEDDDGGDDGETELFRS 1380
              :..|:|..:....|.:...:...|  |.....|..|..|..|..|:.|
  Rat  1327 RHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSS 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_996319.1	M14_CPD_I	40..334	CDD:349440	143/325 (44%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	26/78 (33%)
		M14_CP_N-E_like	456..759	CDD:349431	161/305 (53%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	22/76 (29%)
		Peptidase_M14NE-CP-C_like	1124..1190	CDD:473874	21/65 (32%)
		CarboxypepD_reg	1223..1301	CDD:433354	4/77 (5%)
Cpd	NP_036968.1	Peptidase_M14_like	86..378	CDD:472171	136/301 (45%)
		Cell attachment site. /evidence=ECO:0000255	162..164		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..232		14/42 (33%)
		Peptidase_M14NE-CP-C_like	383..459	CDD:200604	26/78 (33%)
		M14_CPD_II	496..791	CDD:349435	162/312 (52%)
		Peptidase_M14NE-CP-C_like	795..870	CDD:200604	22/74 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	875..898		5/31 (16%)
		M14_CPD_III	931..1208	CDD:349464	61/291 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1039..1068		5/36 (14%)
		Peptidase_M14NE-CP-C_like	1212..1286	CDD:200604	24/105 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1357..1378		6/20 (30%)