DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and cpd-1

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_491619.2	Gene:	cpd-1 / 172206	WormBaseID:	WBGene00019074	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	1068	Identity:	290/1068 - (27%)
Similarity:	453/1068 - (42%)	Gaps:	249/1068 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 LKKQFNGFL--TPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSH 503
            :|.:...|:  ..||.::||:..|.::|:|...:||::|.|||.||||:||:||||.|...|..|
Worm    61 MKAKIGDFINVNSTKLKNHNYNEMTAWLKATRLNYPNITHLYSAGKSVEGRELWVLIISDKPKEH 125

  Fly   504 VPGVPEFKYVANMHGNEVVGKELLLILTKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEISI 568
            ....||.|.|.|||||||||:|.:|.|.:.:...||.:..:|.|||..|:|.:.||||||||...
Worm   126 KLMEPELKIVGNMHGNEVVGREAVLYLAEILCLNYGKNKYLTDLVNNARIHLMPSMNPDGYEKGF 190

  Fly   569 EGDRTGGVGRANAHGIDLNRNFPDQYGTDR-FNKVTEPEV--AAVMNWTLSLPFVLSANLHGGSL 630
            .|||...:|||||:.:|||||||.::.:.| .:..:|||.  .|||.|..:.|||||.|||||||
Worm   191 PGDRISAMGRANANDVDLNRNFPTKFESHRETSGGSEPEKENIAVMKWLQAYPFVLSTNLHGGSL 255

  Fly   631 VANYPFDDNENDFNDPFMRLRNSSINGRKP--NPTEDNALFKHLAGIYSNAHPTMY-LGQPCEL- 691
            |||||:||               |:.|:..  ..:.|:.||..|:..|:.||..|: .|:.|.|
Worm   256 VANYPYDD---------------SVTGQDGIYTASADDKLFVELSYRYARAHTKMWKTGRRCGLS 305

  Fly   692 FQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQF 756
            ...:.|.:||||||.||.:.||||||.|....|||:||||||.|||....:.:.||:|:..||.|
Worm   306 ADGDNFINGITNGAGWYHLAGGMQDWQYEHTNCLEITIEMGCFKFPTDDMMPKLWEEHQFSLLSF 370

  Fly   757 IEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAPLRM 821
            :|....|:.|.|.......:|.|.:.:| ......|...|:||:|..||.|.:||     :...:
Worm   371 LEMGLSGVTGLVTDRNNNTVANATISVD-TGKDIISTEAGEYWRLLPPGDHQITV-----SARGL 429

  Fly   822 EVEVPDVHPFEMRMDITLMPDDPQHWASANDFRII---ENVVNTRYHTNPQVRARLAELENQNGQ 883
            |.:.         ..:|::|...   |:.:|..::   :|...:..:    :|.|...|
Worm   430 ESDT---------FTVTIVPGAR---AARHDITLLACGDNETKSEMY----IRGRGKNL------ 472

  Fly   884 IASFGYADSEFGTIFNYLKMTSDIGEPEEHKYKLLVVSSLYDTTAPLGREILLNLIRHLVEGFKL 948
            ||...:               .|||.....:...|..:..:    .:.:::.|.||.::....|.
Worm   473 IAVLSF---------------DDIGGKAVDELARLTCTGDF----VIDKDVSLMLIPNMTGELKG 518

  Fly   949 Q----DTSVVELLKRSVIYFLPQTSKFQ------NVFDMYNSNTSICDPVLGDEL-AERILGPET 1002
            :    |.:.|.::.:.::    :|:.|.      .:||....:.|:. ..||:.: .||.|....
Worm   519 RLTDFDPAAVLIISKGIV----ETATFSVSENEPKLFDKAKMDESLL-KALGNSIQCERTLLESK 578

  Fly  1003 DQAKDVFLQFLRSERFDLMLTFGAGNSDLNYPKGDSVLVKFAHRMQR-------TEFNYSPLQCP 1060
            ...:...||..::  |:|.::.|.  .|.|..|..:.:...|..::.       :||:..|...|
Worm   579 TAMRVDDLQLKKA--FELGISIGC--DDTNVEKKAATIGTIADMIKNELIKDSVSEFSVVPSAHP 639

  Fly  1061 -------------PSATRQLHR-ETTERLTNMMYRIYNL----PVYTLGISCCRMPHQKKIASVW 1107
                         .:|..:|.| |..:.:|....:.|.:    |.|||            ||:|.
Worm   640 GDHFTPDQMIHVTSAAVAELERKECVQEVTRGPSKFYLMGSGKPPYTL------------IAAVE 692

  Fly  1108 RK-------------NIDKIKNFLALVKTGVSGLV-------------QNDKGQPLREAYVRLLE 1146
            ::             |.|....|..::..  |.||             ..|...|.     :||.
Worm   693 KRTEAMAYEMMSTYCNPDTKSEFSDILDE--STLVFMPEIPHTQLNCHDYDTISPF-----KLLF 750

  Fly  1147 HDRIINVTKNVARFQLMLPHGLYGLEVTAPNYESQMIKVDVEDGRVTELGIIRMHPFTLIRGVVL 1211
            .|.|..|.:  ..|.::|..|  |::|...|....:.||..|..| |...:::.   |...|...
Worm   751 DDAIAAVPQ--LDFVIILATG--GMKVRYINDTLGIGKVIAETYR-TNHDLMKA---TDQEGCAK 807

  Fly  1212 ELPN----------NDNRATTSIAGV-------------------------VLDESNHPVRNA-- 1239
            ..||          |||.:....:||                         :..|:...::.|
Worm   808 GFPNEKEAIRAFSWNDNASRMDKSGVDHATDNLDALLVQIGCCYENMASGHLYSENQRAIKTALI 872

  Fly  1240 ----KVSVVGQT--------QLRNFTGSMGQYRISAVPLGTITLKVEAPRHLEATRQMHLIQGGL 1292
                .|.::|.|        .:......:|..|...:|.|...:||..|     ..|||
Worm   873 ERSRGVRIIGGTDGMSVSVDHMHKRLPLLGGRRFVPLPNGEHLVKVRTP-----GGQMH------ 926

  Fly  1293 ATENVVFHLKVNEHVFGLPRFLFILCASVLII-VGVIVCVLCAQFWFYRR------HRGDKPYYN 1350
                ..|.:.:::....:.:|:.:..::::|| :..|:.::|..|...:|      .||   ::|
Worm   927 ----AQFAVVISDRTPTVEKFVGVQSSNMVIITIASILMIICCTFMCRQRVTSVLNRRG---FFN 984

  Fly  1351 FSLLPQRGKEQFGLEDDDGGDDGETELF 1378
             .:..:.|.|:..|...|  |:.|.|:|
Worm   985 -GMGSKGGFERIPLYKSD--DEDEDEVF 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604
		M14_CP_N-E_like	456..759	CDD:199842	145/309 (47%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	17/75 (23%)
		CarbopepD_reg_2	1125..1202	CDD:290434	21/89 (24%)
		CarboxypepD_reg	1223..1301	CDD:290350	18/116 (16%)
cpd-1	NP_491619.2	M14_CP_N-E_like	79..373	CDD:199842	145/308 (47%)
cpd-1	NP_491619.2	Peptidase_M14NE-CP-C_like	377..451	CDD:200604	21/91 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165976
Domainoid	1	1.000	262	1.000	Domainoid score	I1037
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4819
orthoMCL	1	0.900	-	-		OOG6_104026
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3496
SonicParanoid	1	1.000	-	-		X3326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780