DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment svr and CPXM2

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_937791.2	Gene:	CPXM2 / 119587	HGNCID:	26977	Length:	756	Species:	Homo sapiens

Alignment Length:	652	Identity:	193/652 - (29%)
Similarity:	285/652 - (43%)	Gaps:	167/652 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 SFSGGITNGAH-WYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTL----PQEWQRNKASLLQ 330
            |:...::|.:| |..:..|..|..:..::..|:.: |:....|..:..    ||.|..|.:..::
Human   224 SYKVMVSNDSHTWVTVKNGSGDMIFEGNSEKEIPV-LNELPVPMVARYIRINPQSWFDNGSICMR 287

  Fly   331 LLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTS 395
            :             :..|.|:.|.|.|                |.|
Human   288 M-------------EILGCPLPDPNNY----------------YHR------------------- 304

  Fly   396 APQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQFNGFLTPTKYEHHNFT 460
             ..::..|:|      ||||                                        |||:.
Human   305 -RNEMTTTDD------LDFK----------------------------------------HHNYK 322

  Fly   461 AMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVANMHGNEVVGKE 525
            .|...::.::...|::||:|:||||.||..|:.:||...||.|..|.|||.|:|..|||||:|:|
Human   323 EMRQLMKVVNEMCPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYIAGAHGNEVLGRE 387

  Fly   526 LLLILTKYMLERY-GNDDRITKLVNGTRMHFLYSMNPDGYEISIE-GDRTGG--VGRANAHGIDL 586
            |||:|.:::.:.| ..:.||..||..||:|.|.|:||||||.:.| |...||  :||....|||:
Human   388 LLLLLVQFVCQEYLARNARIVHLVEETRIHVLPSLNPDGYEKAYEGGSELGGWSLGRWTHDGIDI 452

  Fly   587 NRNFPD-----QYGTDRFN---KV-----------------TEPEVAAVMNWTLSLPFVLSANLH 626
            |.||||     ....||.|   ||                 ...|..||:.|...:||||..||.
Human   453 NNNFPDLNTLLWEAEDRQNVPRKVPNHYIAIPEWFLSENATVAAETRAVIAWMEKIPFVLGGNLQ 517

  Fly   627 GGSLVANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTM--YLGQPC 689
            ||.||..||:|            |..|....::..||.|:.:|:.||..|::.|..|  ...:.|
Human   518 GGELVVAYPYD------------LVRSPWKTQEHTPTPDDHVFRWLAYSYASTHRLMTDARRRVC 570

  Fly   690 --ELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREP 752
              |.||.|   :|..|||.|::|.|.:.|::|:...|.||:|.:||||:|..::|...||::||.
Human   571 HTEDFQKE---EGTVNGASWHTVAGSLNDFSYLHTNCFELSIYVGCDKYPHESQLPEEWENNRES 632

  Fly   753 LLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYA 817
            |:.|:||||.||.|.|..:.|..|..|::.::|.||...:...||||:|..||.:.:|...:.:.
Human   633 LIVFMEQVHRGIKGLVRDSHGKGIPNAIISVEGINHDIRTANDGDYWRLLNPGEYVVTAKAEGFT 697

  Fly   818 PLRMEVEVPDVHPFEM---RMDITLMPDDPQHWASANDFRIIENVVNTRYHTNP-QVRARLAELE 878
            .......|    .::|   |.|.||        :..|..||.|  :..::...| .:.||..:|.
Human   698 ASTKNCMV----GYDMGATRCDFTL--------SKTNMARIRE--IMEKFGKQPVSLPARRLKLR 748

  Fly   879 NQ 880
            .|
Human   749 GQ 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	13/67 (19%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	12/77 (16%)
		M14_CP_N-E_like	456..759	CDD:199842	130/335 (39%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	22/78 (28%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
CPXM2	NP_937791.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..131
		FA58C	137..292	CDD:238014	13/81 (16%)
		FA58C	138..293	CDD:214572	13/82 (16%)
		M14_CPX_like	314..639	CDD:199851	134/379 (35%)
		Peptidase_M14NE-CP-C_like	643..718	CDD:200604	22/78 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10468
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920