DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment svr and cpxm1b

DIOPT Version :9

Sequence 1:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	XP_009289577.1	Gene:	cpxm1b / 100330305	ZFINID:	ZDB-GENE-141212-305	Length:	959	Species:	Danio rerio

Alignment Length:	636	Identity:	195/636 - (30%)
Similarity:	297/636 - (46%)	Gaps:	155/636 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 KGLVTDASGFPIADANVYVAG----LEEK----PMRTSKRGEYWRLLTPGLYSV----HASAFGY 392
            :|.:...||  :.|.::|..|    .|::    .:...|...:..::..|..|:    :..:|
Zfish   351 RGRLNIQSG--VEDGDIYDGGWCAQYEDQQQWLQIHAQKLTRFTAVILQGRSSIWSLDYVESF-- 411

  Fly   393 QTSAPQQVRVTNDNQEALRLDFKLAPV-----ETNFDGNF---RKVKVERSEP---------PQK 440
                  :|:|:||.       .|..|.     |..|:||.   ..|.....||         ||.
Zfish   412 ------KVQVSNDT-------IKWKPCMNGTQEAVFEGNTDSETPVLALLPEPAVAQYIRINPQS 463

  Fly   441 --------LKKQFNGFLTP-----------------TKYEHHNFTAMESYLRAISSSYPSLTRLY 480
                    |:.:..|...|                 ..:.|||:..|...:::::...|.:||:|
Zfish   464 WFKNGTICLRAEIMGCELPDPNNIYPWQSEDGSQDKLDFRHHNYKEMRKLMKSVNEMCPDITRIY 528

  Fly   481 SIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVANMHGNEVVGKELLLILTKYMLERY--GNDDR 543
            |||||..|..|:|:||...||.|..|.|||:|||.||||||:|:||.|.|.:::.:.|  || .|
Zfish   529 SIGKSYMGLKLYVMEISDNPGKHELGEPEFRYVAGMHGNEVLGRELQLNLMQFICQEYRRGN-QR 592

  Fly   544 ITKLVNGTRMHFLYSMNPDGYEISI-EGDRTGG--VGRANAHGIDLNRNF--------------- 590
            |..||..||:|.|.:|||||||::. :|....|  :||.:..|||:|.||
Zfish   593 ILHLVKETRIHLLPAMNPDGYEMAYKKGSELAGWALGRYSYEGIDMNHNFADLNTVMWDAIELQT 657

  Fly   591 ------------PDQYGTDRFNKVTEPEVAAVMNWTLSLPFVLSANLHGGSLVANYPFDDNENDF 643
                        |:||.::  :....||..||::|..::|||||||||||.||..||| |...|:
Zfish   658 DKSKLINHYFPIPEQYTSE--DAWVAPETRAVISWMQTIPFVLSANLHGGELVVTYPF-DMTRDW 719

  Fly   644 NDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMYL--GQPCELFQNEFF--PDGITNG 704
            ..            |:..||.|::.|:.||.:|::.:..|..  .:||   .||.|  .:.|.||
Zfish   720 AP------------REQTPTADDSFFRWLATVYASTNHVMSNPDRRPC---HNEDFLRHNNIING 769

  Fly   705 AQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQFIEQVHCGIHGFVH 769
            |.|::|.|.|.|::|:...|.|:|:|:.|||||.|:||...|::::|.||.::||||.||.|.:.
Zfish   770 ANWHTVPGSMNDFSYLHTNCFEVTVELSCDKFPHASELPTEWQNNKESLLVYMEQVHRGIKGVIR 834

  Fly   770 -STIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAPLRMEVEVPDVHPFEM 833
             ......||.|::::|..:|...|...||:|:|..||.:::||..:.|.|......|
Zfish   835 DKDTEAGIADAIIKVDDIDHHIRSAADGDFWRLLNPGDYDITVTAEGYFPASRSCRV-------- 891

  Fly   834 RMDITLMPDDPQHWASANDFRIIENVVNTRYHTNPQVRARLAELENQNGQI 884
                     :.:|:.:..|||:.:.           .:.||.|:..:.|:|
Zfish   892 ---------EYEHYPTLCDFRLTKT-----------PKQRLREILAKGGKI 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	15/87 (17%)
		M14_CP_N-E_like	456..759	CDD:199842	133/338 (39%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	20/76 (26%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
cpxm1b	XP_009289577.1	CAF-1_p60_C	94..294	CDD:292150
		DUF4663	<109..219	CDD:292296
		Sec_Non_Glob	164..>297	CDD:275213
		FA58C	321..479	CDD:214572	27/144 (19%)
		FA58C	323..478	CDD:238014	27/143 (19%)
		M14_CPX_like	500..824	CDD:199851	133/342 (39%)
		Peptidase_M14NE-CP-C_like	828..904	CDD:200604	23/92 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020