DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17896 and ALD2

DIOPT Version :9

Sequence 1:	NP_569845.2	Gene:	CG17896 / 30995	FlyBaseID:	FBgn0023537	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_013893.1	Gene:	ALD2 / 855206	SGDID:	S000004780	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	150/486 - (30%)
Similarity:	241/486 - (49%)	Gaps:	25/486 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFIDGKFVESKTNEWIDVHDPATNQVVTRVPKATQAEMQAALESNKKAFRS-WSNQSILTRQQVM 91
            |||:.:|..|...:.|:..:|||.:.:|....|.:.::..|:::.:.||.: ||..|...|...:
Yeast    23 LFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYL 87

  Fly    92 FKLQALIKENMGELAKNITKEQGKTL-ADAEGDVLRGLQVVEHCC-SIPSLQMGETVANVARDMD 154
            ..|..||:|....||...|.:.||.. ::|:||:.:.||:..:.. |......|.|:. :..:..
Yeast    88 SNLLKLIEEEQDTLAALETLDAGKPYHSNAKGDLAQILQLTRYFAGSADKFDKGATIP-LTFNKF 151

  Fly   155 TYSLVLPLGVTAGVAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGATMLLMELLNEAGCPPG 219
            .|:|.:|.||.|.:.|:|:|..:..|....|:..|||:::||:|....:.:....|:.:||.|||
Yeast   152 AYTLKVPFGVVAQIVPWNYPLAMACWKLQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPG 216

  Fly   220 VVNVIHGQHDAV-NFICDAPEIKAVSFVGSDQAGKYIYERAGK-NGKRVQSNMGAKNHGIILGDA 282
            |||::.|....| ..:....:|..:||.||.:.|.::.|.:|: |.|.|....|.|:..::..||
Yeast   217 VVNIVPGYGSLVGQALASHMDIDKISFTGSTKVGGFVLEASGQSNLKDVTLECGGKSPALVFEDA 281

  Fly   283 NKENTLNQLAGAAFGAAGQRCMALSTAVFVGDA--QAWIPDLVERAQKLKVNAGHVPGTD----V 341
            :.:..::.:|...|..:||.|.| ::.|:|..:  ..::....|.|:|....||.....|    |
Yeast   282 DLDKAIDWIAAGIFYNSGQNCTA-NSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIV 345

  Fly   342 GPVISAASRQRINDLIESGVKEGAKLILDGRKITVPGYEDGYFVGPTILSDVTPSMKCYTEEIFG 406
            |||||:....||...||.|.:|....:....:..:.|.: |||:.|||.:||..:.|...:||||
Yeast   346 GPVISSTQYDRIKSYIERGKREEKLDMFQTSEFPIGGAK-GYFIPPTIFTDVPQTSKLLQDEIFG 409

  Fly   407 PVLVILKADTLDDAIGIVNANPYGNGTAVFTTNGAAARKFVNEIDAGQVGVN----VPIPVPLPM 467
            ||:|:.|....|||:.:.|...||..:||||.:...|..|..:|.||.|.:|    ..:.||...
Yeast   410 PVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINSSNDEDVTVPFGG 474

  Fly   468 FSFTGTRGSFRGDHHFYGKQGIKFYTQTKTV 498
            |..:|.....       |:.|:..|.|||.|
Yeast   475 FKMSGIGREL-------GQSGVDTYLQTKAV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17896	NP_569845.2	ALDH_F6_MMSDH	26..502	CDD:143404	150/486 (31%)
ALD2	NP_013893.1	ALDH_ALD2-YMR170C	14..502	CDD:143462	150/486 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910