DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17896 and ALDH6B2

DIOPT Version :9

Sequence 1:	NP_569845.2	Gene:	CG17896 / 30995	FlyBaseID:	FBgn0023537	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_179032.1	Gene:	ALDH6B2 / 815903	AraportID:	AT2G14170	Length:	607	Species:	Arabidopsis thaliana

Alignment Length:	532	Identity:	310/532 - (58%)
Similarity:	392/532 - (73%)	Gaps:	19/532 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVRLIGAEARHL------AKRSYSSAAPTTKL----------FIDGKFVESKTNEWIDVHDPATN 51
            |:|:.|...|.|      .:.|:.|.:|....          .|.|.||||:::.:|||.:|||.
plant    75 LLRISGNNLRPLRPQFLALRSSWLSTSPEQSTQPQMPPRVPNLIGGSFVESQSSSFIDVINPATQ 139

  Fly    52 QVVTRVPKATQAEMQAALESNKKAFRSWSNQSILTRQQVMFKLQALIKENMGELAKNITKEQGKT 116
            :||::||..|..|.:||:.:.|:||..|.|..|.|||:||.|.|.||::||.:||.|||.|||||
plant   140 EVVSKVPLTTNEEFKAAVSAAKQAFPLWRNTPITTRQRVMLKFQELIRKNMDKLAMNITTEQGKT 204

  Fly   117 LADAEGDVLRGLQVVEHCCSIPSLQMGETVANVARDMDTYSLVLPLGVTAGVAPFNFPAMIPLWM 181
            |.|:.||:.|||:||||.|.:.:|||||.:.||:..:||||:..||||.||:.||||||||||||
plant   205 LKDSHGDIFRGLEVVEHACGMATLQMGEYLPNVSNGVDTYSIREPLGVCAGICPFNFPAMIPLWM 269

  Fly   182 FPVAITTGNTMLLKPSERVPGATMLLMELLNEAGCPPGVVNVIHGQHDAVNFICDAPEIKAVSFV 246
            ||||:|.|||.:|||||:.|||:::|.||..|||.|.||:|::||.:|.||.|||..:|:|||||
plant   270 FPVAVTCGNTFILKPSEKDPGASVILAELAMEAGLPDGVLNIVHGTNDTVNAICDDEDIRAVSFV 334

  Fly   247 GSDQAGKYIYERAGKNGKRVQSNMGAKNHGIILGDANKENTLNQLAGAAFGAAGQRCMALSTAVF 311
            ||:.||.:||.||...|||:||||||||||::|.|||.:.|||.|..|.|||||||||||||.||
plant   335 GSNTAGMHIYARAAAKGKRIQSNMGAKNHGLVLPDANIDATLNALLAAGFGAAGQRCMALSTVVF 399

  Fly   312 VGDAQAWIPDLVERAQKLKVNAGHVPGTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKITV 376
            ||||::|...|||||:.|||..|..|..|:|||||..:::||..||:|||.:||||:||||.|.|
plant   400 VGDAKSWEDKLVERAKALKVTCGSEPDADLGPVISKQAKERICRLIQSGVDDGAKLLLDGRDIVV 464

  Fly   377 PGYEDGYFVGPTILSDVTPSMKCYTEEIFGPVLVILKADTLDDAIGIVNANPYGNGTAVFTTNGA 441
            ||||.|.|:||||||.|||.|:||.|||||||||.::|::.|:||.|:|.|.||||.|:||::||
plant   465 PGYEKGNFIGPTILSGVTPDMECYKEEIFGPVLVCMQANSFDEAISIINKNKYGNGAAIFTSSGA 529

  Fly   442 AARKFVNEIDAGQVGVNVPIPVPLPMFSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRKTD 506
            |||||..:|:|||:|:|||||||||.|||||.:.||.||.:||||.|:.|:||.|||||.|:  |
plant   530 AARKFQMDIEAGQIGINVPIPVPLPFFSFTGNKASFAGDLNFYGKAGVDFFTQIKTVTQQWK--D 592

  Fly   507 VTHTQAAVAMPT 518
            :. |..::||||
plant   593 IP-TSVSLAMPT 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17896	NP_569845.2	ALDH_F6_MMSDH	26..502	CDD:143404	295/485 (61%)
ALDH6B2	NP_179032.1	PLN02419	1..604	CDD:166060	310/532 (58%)
ALDH6B2	NP_179032.1	ALDH_F6_MMSDH	114..590	CDD:143404	295/475 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	601	1.000	Domainoid score	I38
eggNOG	1	0.900	-	-		E1_KOG2449
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4082
Inparanoid	1	1.050	616	1.000	Inparanoid score	I214
OMA	1	1.010	-	-		QHG60884
OrthoDB	1	1.010	-	-		D608999at2759
OrthoFinder	1	1.000	-	-		FOG0006592
OrthoInspector	1	1.000	-	-		oto3989
orthoMCL	1	0.900	-	-		OOG6_102212
Panther	1	1.100	-	-	LDO	PTHR43866
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840