DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17896 and ALDH6A1

DIOPT Version :9

Sequence 1:	NP_569845.2	Gene:	CG17896 / 30995	FlyBaseID:	FBgn0023537	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_005580.1	Gene:	ALDH6A1 / 4329	HGNCID:	7179	Length:	535	Species:	Homo sapiens

Alignment Length:	502	Identity:	343/502 - (68%)
Similarity:	428/502 - (85%)	Gaps:	0/502 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SYSSAAPTTKLFIDGKFVESKTNEWIDVHDPATNQVVTRVPKATQAEMQAALESNKKAFRSWSNQ 82
            |:||:.||.||||.|||||||:::|||:|:||||:|:.|||:||:|||.||:.|.|:||.:|::.
Human    32 SFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADT 96

  Fly    83 SILTRQQVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQMGETVA 147
            |:|:||||:.:.|.|||||:.|:||.||.|||||||||||||.||||||||.||:.||.||||:.
Human    97 SVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMP 161

  Fly   148 NVARDMDTYSLVLPLGVTAGVAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGATMLLMELLN 212
            ::.:|||.||..|||||.||:|||||||||||||||:|:..|||.|:|||||||||||||.:||.
Human   162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQ 226

  Fly   213 EAGCPPGVVNVIHGQHDAVNFICDAPEIKAVSFVGSDQAGKYIYERAGKNGKRVQSNMGAKNHGI 277
            ::|.|.|.:|:|||||:|||||||.|:|||:|||||::||:||:||..::|||||:||||||||:
Human   227 DSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGV 291

  Fly   278 ILGDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQAWIPDLVERAQKLKVNAGHVPGTDVG 342
            ::.|||||||||||.||||||||||||||||||.||:|:.|:|:|||.|:.|:||||..||.|:|
Human   292 VMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLG 356

  Fly   343 PVISAASRQRINDLIESGVKEGAKLILDGRKITVPGYEDGYFVGPTILSDVTPSMKCYTEEIFGP 407
            |:|:..:::|:.:||:||.||||.::||||||.|.|||:|.||||||:|:|.|:|.||.||||||
Human   357 PLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGP 421

  Fly   408 VLVILKADTLDDAIGIVNANPYGNGTAVFTTNGAAARKFVNEIDAGQVGVNVPIPVPLPMFSFTG 472
            |||:|:.:|||:||.|||.||||||||:||||||.|||:.:.:|.||||||||||||||||||||
Human   422 VLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTG 486

  Fly   473 TRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRKTDVTHTQAAVAMPTM 519
            :|.|||||.:|||||||:||||.||:|..|::.|.|.:..||.||||
Human   487 SRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTM 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17896	NP_569845.2	ALDH_F6_MMSDH	26..502	CDD:143404	329/475 (69%)
ALDH6A1	NP_005580.1	ALDH_F6_MMSDH	40..516	CDD:143404	329/475 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159065
Domainoid	1	1.000	685	1.000	Domainoid score	I137
eggNOG	1	0.900	-	-		E1_KOG2449
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4082
Inparanoid	1	1.050	730	1.000	Inparanoid score	I613
Isobase	1	0.950	-	0	Normalized mean entropy	S872
OMA	1	1.010	-	-		QHG60884
OrthoDB	1	1.010	-	-		D238939at33208
OrthoFinder	1	1.000	-	-		FOG0006592
OrthoInspector	1	1.000	-	-		oto88536
orthoMCL	1	0.900	-	-		OOG6_102212
Panther	1	1.100	-	-	LDO	PTHR43866
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720