DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17896 and alh-8

DIOPT Version :9

Sequence 1:	NP_569845.2	Gene:	CG17896 / 30995	FlyBaseID:	FBgn0023537	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001022078.1	Gene:	alh-8 / 174800	WormBaseID:	WBGene00000114	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	344/508 - (67%)
Similarity:	420/508 - (82%)	Gaps:	1/508 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HLAKRSYSSAAPTTKLFIDGKFVESKTNEWIDVHDPATNQVVTRVPKATQAEMQAALESNKKAFR 77
            |.:....::||||.||:|||:.|||||.:::::.:||||:|:..||.|||||||||::|.|.||.
Worm    17 HFSTSKSAAAAPTVKLWIDGQAVESKTTDFVELTNPATNEVIAMVPNATQAEMQAAVDSAKNAFN 81

  Fly    78 SWSNQSILTRQQVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQM 142
            :|.|.|.|||||.|||||||||.:|.:||::||.||||||.||||||.||||||||.||:|||.|
Worm    82 TWKNTSPLTRQQCMFKLQALIKRDMKKLAESITIEQGKTLPDAEGDVSRGLQVVEHACSVPSLMM 146

  Fly   143 GETVANVARDMDTYSLVLPLGVTAGVAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGATMLL 207
            |||:.||:|||||:|..:|||||||:.||||||||||||||||:.|||||::||||:.|||..||
Worm   147 GETLPNVSRDMDTHSYRIPLGVTAGICPFNFPAMIPLWMFPVALATGNTMVIKPSEQDPGAAQLL 211

  Fly   208 MELLNEAGCPPGVVNVIHGQHDAVNFICDAPEIKAVSFVGSDQAGKYIYERAGKNGKRVQSNMGA 272
            :||..|||.|.|.||:|||||.|||||||.|:|||:||||.|.|||:||||..||||||||||||
Worm   212 VELAKEAGVPDGCVNIIHGQHSAVNFICDNPDIKAISFVGGDAAGKHIYERGAKNGKRVQSNMGA 276

  Fly   273 KNHGIILGDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQAWIPDLVERAQKLKVNAGHVP 337
            ||||:|:.|||||.|||||..|||||||||||||:|||.||:|:||:|:|||:|:.||||||..|
Worm   277 KNHGVIMADANKEQTLNQLTAAAFGAAGQRCMALTTAVLVGEARAWLPELVEKAKNLKVNAGWKP 341

  Fly   338 GTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKITVPGYEDGYFVGPTILSDVTPSMKCYTE 402
            .||:||:||..|:.|:..||||..||||::.|||..|||||:|:|.|||||||:.|.|:|.||.|
Worm   342 DTDIGPLISKQSKARVLRLIESAKKEGAQVPLDGSNITVPGFENGNFVGPTILAGVKPNMTCYRE 406

  Fly   403 EIFGPVLVILKADTLDDAIGIVNANPYGNGTAVFTTNGAAARKFVNEIDAGQVGVNVPIPVPLPM 467
            ||||||||:::|:.|::||.|:|.||||||||:||:|||.||||.||:|.||:|:||||||||||
Worm   407 EIFGPVLVVMEAENLNEAIEIINNNPYGNGTAIFTSNGATARKFTNEVDVGQIGINVPIPVPLPM 471

  Fly   468 FSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRKTDVTHTQAAVAMPTMK 520
            |||||:||||.||.:||||.||:||||.|||||.|.:: :|..:..::.|.:|
Worm   472 FSFTGSRGSFLGDLNFYGKAGIQFYTQWKTVTQYWNES-LTELKPQMSFPQLK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17896	NP_569845.2	ALDH_F6_MMSDH	26..502	CDD:143404	335/475 (71%)
alh-8	NP_001022078.1	PLN02466	18..502	CDD:215259	335/483 (69%)
alh-8	NP_001022078.1	ALDH_F6_MMSDH	30..506	CDD:143404	335/475 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166654
Domainoid	1	1.000	671	1.000	Domainoid score	I65
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4082
Inparanoid	1	1.050	713	1.000	Inparanoid score	I334
Isobase	1	0.950	-	0	Normalized mean entropy	S872
OMA	1	1.010	-	-		QHG60884
OrthoDB	1	1.010	-	-		D238939at33208
OrthoFinder	1	1.000	-	-		FOG0006592
OrthoInspector	1	1.000	-	-		oto18007
orthoMCL	1	0.900	-	-		OOG6_102212
Panther	1	1.100	-	-	LDO	PTHR43866
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2648
SonicParanoid	1	1.000	-	-		X4835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890