Protein Alignment CG3156 and ABCB11

DIOPT Version :10

• Sequence 1: NP_569844.2
• Gene: CG3156 / 30994
• FlyBaseID: FBgn0023536
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: XP_011510380.1
• Gene: ABCB11 / 8647
• HGNCID: 42
• Length: 1355
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 223/678 - (32%)
• Similarity: 335/678 - (49%)
• Gaps: 72/678 - (10%)

  Fly    69 CMRRGFAQS-SKWLA-----------RNAKANL-PTAVGAGIVPAPVKMGRSQYGRLLSLTKSEK 120
            |.|||..:| :.|.:           .:.|:.| ....|.|     |::|..|..|..|.|  :.
Human    36 CTRRGENKSRTSWSSFKEQKKISNNNNDKKSRLQDEKKGDG-----VRVGFFQLFRFSSST--DI 93

  Fly   121 WVLTAGIGCLVVSSAITMSVPLFLGKVIDV-----------------------VFNKSGMD---- 158
            |::..|..|..:.......|.|..|.:.||                       |:..|.::
Human    94 WLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMT 158

  Fly   159 ----------SAAMAKLGEYSVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQE 213
                      .:.|.|...|..   ||.|......:.::..:..||.|.::.:|...:|.::..|
Human   159 NGTRCGLLNIESEMIKFASYYA---GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRME 220

  Fly   214 VGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPA 278
            :||||....|||..|.|:|...:..:::..::..::.:.....|..:..:...:|..|...|.|.
Human   221 IGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPL 285

  Fly   279 MAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGY 343
            :...|...|..|.:.|..||..||:....|:|...:::||..|..|::||..::..|..|.:.|.
Human   286 IGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGI 350

  Fly   344 KETRARAIFFGLTGF--CGNFIIISV-LYYGGTLVLQD-SLTIGALTAFMLYAGYVAISMNGLSN 404
            ::......|   |||  |..|:..:: .:||.||||.: ..|.|.|....|.....|:::...|.
Human   351 RKGIVMGFF---TGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASP 412

  Fly   405 FYSQLNKGIGASERIWEILDRECSIP-IDKGVVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSL 468
            .......|..|:..|:|.:||:..|. :.:....|::..||:.|.||.|.:|:|||..:|.|.::
Human   413 CLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNM 477

  Fly   469 NLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLF 533
            .:.||..||:||.||:||:|...|:.|.|||..|.|.:||.|:|::|.||||:.||.|.||||||
Human   478 VIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLF 542

  Fly   534 SCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIA 598
            |.:|.|||.||.   |..:.|.:.|..::||...|...||...|||||:.|..:|||||||||||
Human   543 STTIAENIRYGR---EDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIA 604

  Fly   599 RALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIV 663
            ||||:||.||:||.||||||..||.:||..|..:..|.|::::||||||:|.||.|.....|..|
Human   605 RALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAV 669

  Fly   664 EQGSYNELMGIQEGVFRELVASQAFGSR 691
            |:|::.||:. ::||:..||..|:.|::
Human   670 ERGTHEELLE-RKGVYFTLVTLQSQGNQ 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	103..687	CDD:440747	210/625 (34%)
ABCB11	XP_011510380.1	PTZ00265	52..1348	CDD:240339	217/662 (33%)
		MdlB	773..1350	CDD:440747