Protein Alignment CG3156 and MDL2

DIOPT Version :9

• Sequence 1: NP_569844.2
• Gene: CG3156 / 30994
• FlyBaseID: FBgn0023536
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_015053.2
• Gene: MDL2 / 855858
• SGDID: S000006191
• Length: 773
• Species: Saccharomyces cerevisiae
• Alignment Length: 685
• Identity: 246/685 - (35%)
• Similarity: 374/685 - (54%)
• Gaps: 73/685 - (10%)

  Fly    48 SLPPPNRYHSHLHPTLRMPWWCMR----------RGF-AQSSKWLARNAKANLPTAVGAGIVPAP 101
            ||..|:  .|.|.|..|:   |:|          :.| ..|||.:   .:.:||:|       :|
Yeast    33 SLVTPS--SSQLIPLSRL---CLRSPAVGKSLILQSFRCNSSKTV---PETSLPSA-------SP 82

  Fly   102 VKMG--RSQYG-------------RLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVV 151
            :..|  ||.:.             ||..|.|.:..:|...|..|.:|.:|.||:|..:|.|:|.:
Yeast    83 ISKGSARSAHAKEQSKTDDYKDIIRLFMLAKRDWKLLLTAILLLTISCSIGMSIPKVIGIVLDTL 147

  Fly   152 FNKSGMDSAAMAKLGEYSVLLFGI-------FVLGGFANFARVHLFGNAALRIVRSLRSRLYRSM 209
            ...||.|...: |:..:|:.|:..       .::|..|||.|..|....:.|:|..||:.:.:..
Yeast   148 KTSSGSDFFDL-KIPIFSLPLYEFLSFFTVALLIGCAANFGRFILLRILSERVVARLRANVIKKT 211

  Fly   210 LMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSAL 274
            |.|:..:||....|:||:||.:|..:|..|::|.||||::::....||.|||...||||:.:...
Yeast   212 LHQDAEFFDNHKVGDLISRLGSDAYVVSRSMTQKVSDGVKALICGVVGVGMMCSLSPQLSILLLF 276

  Fly   275 VVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEAL 339
            ..|.:...|.|:|:.:|..:|...:...::.:.|||:...:|||::|..|..|::.::..:.:..
Yeast   277 FTPPVLFSASVFGKQIRNTSKDLQEATGQLTRVAEEQLSGIKTVQSFVAEGNELSRYNVAIRDIF 341

  Fly   340 QIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSN 404
            |:|.......|.||..|...|:...::||.||..||||..|:||.|||||||..|...::.|||.
Yeast   342 QVGKTAAFTNAKFFTTTSLLGDLSFLTVLAYGSYLVLQSQLSIGDLTAFMLYTEYTGNAVFGLST 406

  Fly   405 FYSQLNKGIGASERIWEILDRECSI---------PIDKGVVPLEKPVGEVGFQNVFFTFPTRPES 460
            |||::.:|.||:.|::|:.||:.||         | |:||:.         |::|.|::||||..
Yeast   407 FYSEIMQGAGAASRLFELTDRKPSISPTVGHKYKP-DRGVIE---------FKDVSFSYPTRPSV 461

  Fly   461 AVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGA 525
            .:..:.:..:.||::..:||.||.||:|||||:||.|:|..||:.:|..|:..:|.:.||.:||.
Yeast   462 QIFKNLNFKIAPGSSVCIVGPSGRGKSTIALLLLRYYNPTTGTITIDNQDISKLNCKSLRRHIGI 526

  Fly   526 VSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGG 590
            |.|||||.|.:||:||.||..  .||:.|.::.|.:......|..:.|:..||::|..|.:||||
Yeast   527 VQQEPVLMSGTIRDNITYGLT--YTPTKEEIRSVAKQCFCHNFITKFPNTYDTVIGPHGTLLSGG 589

  Fly   591 QKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGR--TVLTIAHRLSTIRNADQ 653
            ||||:||||||||.|.||||||||||||..||..:......|::.:  |:::|||||||||.::.
Yeast   590 QKQRIAIARALIKKPTILILDEATSALDVESEGAINYTFGQLMKSKSMTIVSIAHRLSTIRRSEN 654

  Fly   654 IAVLS-DGKIVEQGSYNELMGIQEGVFRELVASQA 687
            :.||. ||.:||.|.:.||.........:|:..:|
Yeast   655 VIVLGHDGSVVEMGKFKELYANPTSALSQLLNEKA 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	227/612 (37%)
		ABC_membrane	127..395	CDD:279056	92/274 (34%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	108/241 (45%)
MDL2	NP_015053.2	3a01208	1..685	CDD:273363	244/679 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344925
Domainoid	1	1.000	166	1.000	Domainoid score	I810
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6474
Inparanoid	1	1.050	402	1.000	Inparanoid score	I312
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	1	1.000	-	-		otm46909
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1969
SonicParanoid	1	1.000	-	-		X2387
TreeFam	1	0.960	-	-
	13	12.690