DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and MDL1

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_013289.1	Gene:	MDL1 / 850885	SGDID:	S000004178	Length:	695	Species:	Saccharomyces cerevisiae

Alignment Length:	716	Identity:	252/716 - (35%)
Similarity:	390/716 - (54%)	Gaps:	80/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RLTHLCTTLRVRKSSQIRLSTSYNHHLGRCLHHRTARSLQHSLPP-----------PNRYHSHLH 60
            |:..||...::.:|.....|..|           :.:||  ..||           |:|.|..|.
Yeast     4 RMIRLCKGPKLLRSQFASASALY-----------STKSL--FKPPMYQKAEINLIIPHRKHFLLR 55

  Fly    61 PTLRMPWWCMRRGFAQSSKWLARNAKANLPTAVGAGIVPAPVKM--------GRSQYGRLLSLTK 117
             ::|:          ||.  :|:..|:..||          :|:        |.....||..|:|
Yeast    56 -SIRL----------QSD--IAQGKKSTKPT----------LKLSNANSKSSGFKDIKRLFVLSK 97

  Fly   118 SEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVFNKSGMDSAAMAKLGEYSVLLFG-------- 174
            .|...:...:..:::||:::|:||..:||::|:.....|.|..     |..|..|:|
Yeast    98 PESKYIGLALLLILISSSVSMAVPSVIGKLLDLASESDGEDEE-----GSKSNKLYGFTKKQFFT 157

  Fly   175 ----IFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLM 235
                :|::|..||.:|:.:......|:|..||:|..::.|.|:..:.||...|:||:|||:|..:
Yeast   158 ALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMKAALDQDATFLDTNRVGDLISRLSSDASI 222

  Fly   236 VGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDK 300
            |..|::||||||.|::....||.|||.:.|.:|..|..::.|.:..||::|||.:|.:::.....
Yeast   223 VAKSVTQNVSDGTRAIIQGFVGFGMMSFLSWKLTCVMMILAPPLGAMALIYGRKIRNLSRQLQTS 287

  Fly   301 YAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFIII 365
            ...:.|.|||:....:|::.:..|:.||..:..::.....||.||.....:|||.||..||..::
Yeast   288 VGGLTKVAEEQLNATRTIQAYGGEKNEVRRYAKEVRNVFHIGLKEAVTSGLFFGSTGLVGNTAML 352

  Fly   366 SVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECSI- 429
            |:|..|.:::...|:|:|.|::||:||.|...|:.|||:|||:|.||.||:.|::|:.||:..|
Yeast   353 SLLLVGTSMIQSGSMTVGELSSFMMYAVYTGSSLFGLSSFYSELMKGAGAAARVFELNDRKPLIR 417

  Fly   430 -PIDKGVVPL-EKPVGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALL 492
             .|.|..|.| :||   :.|:||.||:||||:..:..|.::.:.||.....||.|||||:|||.|
Yeast   418 PTIGKDPVSLAQKP---IVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVCAVGPSGSGKSTIASL 479

  Fly   493 MLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQ 557
            :||.||...|::.....|:|..|.:..|..||.|.|||:||:.:|.:||||...|......:|::
Yeast   480 LLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTILDNILYCIPPEIAEQDDRIR 544

  Fly   558 QVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSE 622
            :.|..||.::|....||||.|:||.||..||||||||:|:|||.:.:||:|||||||||||:.||
Yeast   545 RAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLLDPAVLILDEATSALDSQSE 609

  Fly   623 NLVQNALDNLIQ-GRTVLTIAHRLSTIRNADQIAVL-SDGKIVEQGSYNELMGIQEGVFRELVAS 685
            .:|...|...:: |.|.::||||||||:::.::.|| ..|.:||.||:.:|:.|.......|:|.
Yeast   610 EIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETGSFRDLIAIPNSELNALLAE 674

  Fly   686 Q 686
            |
Yeast   675 Q 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	229/598 (38%)
		ABC_membrane	127..395	CDD:279056	89/279 (32%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	110/240 (46%)
MDL1	NP_013289.1	MdlB	116..676	CDD:224055	222/568 (39%)
		ABC_membrane	116..386	CDD:279056	88/274 (32%)
		ABC_MTABC3_MDL1_MDL2	432..676	CDD:213216	111/244 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344926
Domainoid	1	1.000	166	1.000	Domainoid score	I810
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I312
Isobase	1	0.950	-	0	Normalized mean entropy	S1123
OMA	1	1.010	-	-		QHG54509
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	1	1.000	-	-		otm46909
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1969
SonicParanoid	1	1.000	-	-		X2387
TreeFam	1	0.960	-	-
	14	13.640