DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and ABCB4

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_001323911.1	Gene:	ABCB4 / 819314	AraportID:	AT2G47000	Length:	1286	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	205/560 - (36%)
Similarity:	323/560 - (57%)	Gaps:	34/560 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LFLGKVIDVVFNKSGMDSAAMAKLGEYSVLLFGIFVLGGF-ANFARVHLFGNAALRIVRSLRSRL 205
            |..|.:||.........:..::|:    .|.|....:|.| |.|.::..:..:..|....:||..
plant    82 LLFGDLIDAFGENQTNTTDKVSKV----ALKFVWLGIGTFAAAFLQLSGWMISGERQAARIRSLY 142

  Fly   206 YRSMLMQEVGWFD-TKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVA------MIGVGTGMMIY 263
            .:::|.|::.:|| ...|||::.|:|.||:::..::.:.|...::.:|      :|....|.::
plant   143 LKTILRQDIAFFDIDTNTGEVVGRMSGDTVLIQDAMGEKVGKAIQLLATFVGGFVIAFVRGWLL- 206

  Fly   264 TSPQLAAVSALVVPAMAG--MAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQ 326
            |...|:::..||   |||  :|||..:...|    ....||:.....|:..|:::||.:|..|:|
plant   207 TLVMLSSIPLLV---MAGALLAIVIAKTASR----GQTAYAKAATVVEQTIGSIRTVASFTGEKQ 264

  Fly   327 EVAAFDGKLDEALQIGYKETRARAIFFG---LTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAF 388
            .::.::..|..|.:.|..|..:..:..|   |..||...:.:   :|||.|:|....|.|.:...
plant   265 AISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYALAV---WYGGKLILDKGYTGGQVLNI 326

  Fly   389 MLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECSIP--IDKGVVPLEKPVGEVGFQNVF 451
            ::.....::|:...|...|....|..|:.:::|.::|..:|.  ...|.| |:...|::..::|:
plant   327 IIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFETIERRPNIDSYSTNGKV-LDDIKGDIELKDVY 390

  Fly   452 FTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNP 516
            ||:|.||:..:...|||.:..|||.|:||:|||||:|:..|:.|.||||.|.|.:|||:|:....
plant   391 FTYPARPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVVSLIERFYDPQAGDVLIDGINLKEFQL 455

  Fly   517 QWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVG 581
            :|:|:.||.||||||||:.||::||.||.   |..:.|.::...|.||.|:|.|:||.||||:||
plant   456 KWIRSKIGLVSQEPVLFTASIKDNIAYGK---EDATTEEIKAAAELANASKFVDKLPQGLDTMVG 517

  Fly   582 QRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLS 646
            :.|..||||||||:|:|||::|:|.||:||||||||||.||.:||.|||.::..||.:.:|||||
plant   518 EHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVVVAHRLS 582

  Fly   647 TIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVASQ 686
            |:||||.|||:..|||||:||:.||:...||.:.:|:..|
plant   583 TVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQLIRLQ 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	205/560 (37%)
		ABC_membrane	127..395	CDD:279056	64/265 (24%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	128/238 (54%)
ABCB4	NP_001323911.1	PTZ00265	46..1280	CDD:240339	205/560 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910