DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and Abcb8

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_083296.2	Gene:	Abcb8 / 74610	MGIID:	1351667	Length:	717	Species:	Mus musculus

Alignment Length:	717	Identity:	258/717 - (35%)
Similarity:	384/717 - (53%)	Gaps:	95/717 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TLRVRKSSQIRLSTSYNHHLGRCLHHRTARSLQHSLP--PPNRYHSHLHPTLRMPWWCMRRGFAQ 76
            |....:||..|||:    ||.|.:.....:...| ||  ||   .||..|:.    ||
Mouse    27 TFSAARSSDDRLSS----HLLRTVAQLRVQLRAH-LPRAPP---ASHWSPSA----WC------- 72

  Fly    77 SSKWLARNAKANLPTAVGAGIVPAPVKMGRSQYGRLLSLTKSE-----------------KWVL- 123
               |:.           |..:|||.:    .|:.||..:...|                 .|.|
Mouse    73 ---WVG-----------GTLVVPAVL----WQHPRLCLIALCEAKESPPAQPTRAPELRFNWKLF 119

  Fly   124 -------TAGIGCLVV----SSAITMSVPLFLGKVIDVV--FNKSGMDS--AAMAKLGEYSVLLF 173
                   ...:|..:|    ::.:.:.:||.||:::::|  :.:..|.|  :...||....:||:
Mouse   120 WHFLHPHLLALGAAIVLALGAALVNVQIPLLLGQLVEIVAKYTRDHMGSFVSESRKLSVQLLLLY 184

  Fly   174 GIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGT 238
            |:   .|...|..:.|..:...|:...:|..|:.|:|.|::.:||.|.||:|::||:.|.....:
Mouse   185 GV---QGLLTFGYLVLLSHIGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKS 246

  Fly   239 SLSQNVSDGLRS-VAMIG--VGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDK 300
            |....:|.|||| ..:||  |...|:   ||:|..:.|:|.||:.|:..:.|..:|::::...::
Mouse   247 SFKLVISQGLRSCTQVIGSLVSLSML---SPRLTLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQ 308

  Fly   301 YAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLD----EALQIGYKETRARAIFFGLTGFCGN 361
            .|.....|:|..|||:||:.|..|::|...:..:|:    :|.::|    |..|:|.||:....|
Mouse   309 IARATGVADEALGNVRTVRAFAMEKREEERYQAELESCCCKAEELG----RGIALFQGLSNIAFN 369

  Fly   362 FIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRE 426
            .:::..|:.||:||....|..|.|.:|::.:..|..||..||..:.|:.:|:.|..|::|.:...
Mouse   370 CMVLGTLFIGGSLVAGQQLKGGDLMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMALS 434

  Fly   427 CSIPIDKG-VVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIA 490
            ..||:..| .:|.:...|.:.||||.|::|.||...||.||:|.|..|...|:||:||.||||:|
Mouse   435 PVIPLTGGYCIPNKDIRGSITFQNVTFSYPCRPGFNVLKDFTLKLPSGKIVALVGQSGGGKTTVA 499

  Fly   491 LLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNN-IGAVSQEPVLFSCSIRENILYGANPGETPSPE 554
            .|:.|.|||:.|:|.|||.||||:||.|||.. ||.:|||||||:.:|.|||.:|....   |.|
Mouse   500 SLLERFYDPEAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDA---SDE 561

  Fly   555 RLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDA 619
            .:.....:||..:|....|||..|:||:||..||||||||:||||||||.|.:||||||||||||
Mouse   562 EVYTAAREANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDA 626

  Fly   620 VSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVA 684
            .||.:||.|||....|||||.|||||||:|.|..|.|:::|::.|.|::.||:. :.|::.||:.
Mouse   627 ESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLK-KGGLYSELIR 690

  Fly   685 SQ 686
            .|
Mouse   691 RQ 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	234/623 (38%)
		ABC_membrane	127..395	CDD:279056	81/282 (29%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	131/239 (55%)
Abcb8	NP_083296.2	MdlB	116..695	CDD:224055	230/591 (39%)
Abcb8	NP_083296.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730