DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3156 and TAP2

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_000535.3	Gene:	TAP2 / 6891	HGNCID:	44	Length:	703	Species:	Homo sapiens

Alignment Length:	657	Identity:	213/657 - (32%)
Similarity:	328/657 - (49%)	Gaps:	67/657 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SLPPPNRYHSHLHPTLRMPWWCMRRGFAQSSKWLARNAKANLPTAVGAGIVPAPVKMGRSQ---- 108
            |..||.|..|       .||..:..|:          ..|.|..::.|.:.| |....:.|
Human    87 SRAPPARVAS-------APWSWLLVGY----------GAAGLSWSLWAVLSP-PGAQEKEQDQVN 133

  Fly   109 ----YGRLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVFNKSGMDSAAMAKLGEYS 169
                ..|||.|::.:..:|.|....||::......:|.:.|:|||::  ....|..|.|....:.
Human   134 NKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL--GGDFDPHAFASAIFFM 196

  Fly   170 VLL-FGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDT 233
            .|. ||..:..|    .|...|.....||...:|.:|:.|:|.|::|:|....||||.:|||:||
Human   197 CLFSFGSSLSAG----CRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDT 257

  Fly   234 LMVGTSLSQNVSDGLRS-VAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVE 297
            .::...|..|.:..||| |.::|: .|.|:..||:|..:|.|.:|.......||....:.:.:..
Human   258 TLMSNWLPLNANVLLRSLVKVVGL-YGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREI 321

  Fly   298 LDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNF 362
            .|..|...:...|..|.::||::|..|:.||..:...|::..|:.::....||::         .
Human   322 QDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALY---------L 377

  Fly   363 IIISVLYYG--------GTLVLQD-SLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASER 418
            ::..||:.|        |...:|| .||.|:|.:||:|...|...:..|...|..:...:||:|:
Human   378 LVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEK 442

  Fly   419 IWEILDRECSIPIDKGVVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSG 483
            ::..:||:.::|....:.|.... |.|.||:|.|.:|.||:..||...:..|.||..||:||.:|
Human   443 VFSYMDRQPNLPSPGTLAPTTLQ-GVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNG 506

  Fly   484 SGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPG 548
            |||:|:|.|:..||.|.||.|.||...:......:|.:.:.:|.|||||||.|:|.||.||....
Human   507 SGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSC 571

  Fly   549 ETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEA 613
            |   .:::....:.|:...|..::..|:.|.||::|..|:.|||||:||||||:::|.:||||||
Human   572 E---DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEA 633

  Fly   614 TSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEG- 677
            |||||...|..:|:.  |....||||.|||||..::.|.||.||.:||:      .:|..:|||
Human   634 TSALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL------QKLAQLQEGQ 690

  Fly   678 -VFRELV 683
             ::..||
Human   691 DLYSRLV 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	200/599 (33%)
		ABC_membrane	127..395	CDD:279056	78/278 (28%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	103/239 (43%)
TAP2	NP_000535.3	3a01208	1..697	CDD:273363	211/655 (32%)
		Part of the peptide-binding site. /evidence=ECO:0000269\|PubMed:8955196	301..389		20/96 (21%)
		Part of the peptide-binding site. /evidence=ECO:0000269\|PubMed:8955196	414..433		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920