Protein Alignment CG3156 and TAP1

DIOPT Version :10

• Sequence 1: NP_569844.2
• Gene: CG3156 / 30994
• FlyBaseID: FBgn0023536
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_000584.3
• Gene: TAP1 / 6890
• HGNCID: 43
• Length: 748
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 202/619 - (32%)
• Similarity: 313/619 - (50%)
• Gaps: 38/619 - (6%)

  Fly    87 ANLPTA-----VGAGIVPA-------PVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAITMS 139
            |.||.|     :|:..||.       ||:       |||....||...|:..:..:|:||...|:
Human   146 AALPAAALWHKLGSLWVPGGQGGSGNPVR-------RLLGCLGSETRRLSLFLVLVVLSSLGEMA 203

  Fly   140 VPLFLGKVIDVVFNKSGMDSAAMAKLGEYSVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSR 204
            :|.|.|::.|.:......|:.. ..|...|:|.....||    .|....::.|....:...|:..
Human   204 IPFFTGRLTDWILQDGSADTFT-RNLTLMSILTIASAVL----EFVGDGIYNNTMGHVHSHLQGE 263

  Fly   205 LYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGL----RSVAMIGVGTGMMIYTS 265
            ::.::|.||..:|....||.:::|::.||..:..|||:|:|..|    |.:.::|:    |::.|
Human   264 VFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI----MLWGS 324

  Fly   266 PQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAA 330
            ..|..|:.:.:|.:..:....|::.:.:.....:..|:..:.|.|....:.||::|..|:.|...
Human   325 VSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQK 389

  Fly   331 FDGKLDEALQIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYV 395
            |..||.|...:..||..|.|:....|...|..:.:.:||.||.||...:::.|.|..|:||....
Human   390 FREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQF 454

  Fly   396 AISMNGLSNFYSQLNKGIGASERIWEILDRECSIPIDKGVVPLEKPVGEVGFQNVFFTFPTRPES 460
            ..::..|.:.|.::.|.:|:||:|:|.|||....|....:.||... |.|.||:|.|.:|.||:.
Human   455 TQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLE-GLVQFQDVSFAYPNRPDV 518

  Fly   461 AVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGA 525
            .||...:..|.||..||:||.:||||:|:|.|:..||.|.||.:.|||..|.....::|...:.|
Human   519 LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAA 583

  Fly   526 VSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGG 590
            |.|||.:|..|::|||.||..  :.|:.|.:......:....|...||.|.||.|.:.|..||||
Human   584 VGQEPQVFGRSLQENIAYGLT--QKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGG 646

  Fly   591 QKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQ--GRTVLTIAHRLSTIRNADQ 653
            |:|.||:|||||:.|.:||||:|||||||.|:..|:..|....:  .|:||.|...||.:..||.
Human   647 QRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 711

  Fly   654 IAVLSDGKIVEQGSYNELMGIQEGVFRELVASQA 687
            |..|..|.|.|.|::.:||. ::|.:..:|.:.|
Human   712 ILFLEGGAIREGGTHQQLME-KKGCYWAMVQAPA 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	103..687	CDD:440747	192/589 (33%)
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	200/613 (33%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	375..420		14/44 (32%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	453..487		11/33 (33%)