DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and abcb11b

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	XP_003199513.2	Gene:	abcb11b / 571189	ZFINID:	ZDB-GENE-050517-14	Length:	1348	Species:	Danio rerio

Alignment Length:	633	Identity:	213/633 - (33%)
Similarity:	324/633 - (51%)	Gaps:	54/633 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 VKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVF-------------- 152
            :::|..|..|..|.  .|.|::..|..|.:...:....:.|..|.:.|...
Zfish    52 IRVGFFQLFRFASC--REIWMMVFGSLCAIAHGSAQPLMLLVFGMLTDTFIDYDIELNELSDPQK 114

  Fly   153 ----------NKSGMDSAAM---AKLG----EYSVLLF---------GIFVLGGFANFARVHLFG 191
                      |.:..::.|:   ...|    ||.:..|         |:|:||    :.::.|:.
Zfish   115 ACVNNTIQWRNLTQEENLALNMTRSCGLLDIEYEMTNFAYYYVGIGAGVFILG----YLQISLWI 175

  Fly   192 NAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGV 256
            .||.|.::.:|...:|.::..|:||||....|||..|:|:|...:..:::..|...::.......
Zfish   176 TAAARQIQIIRKMYFRKVMRMEIGWFDCTSVGELNTRMSDDINKINDAIADQVGIFIQRFTTFVC 240

  Fly   257 GTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTF 321
            |..|......:|..|...|.|.:...|.:...:|.::|.:||..||:....|:|...:|:||..|
Zfish   241 GFLMGFARGWKLTLVIISVSPLIGIGAGLMALFVAKLTGMELQAYAKAGAVADEVLSSVRTVAAF 305

  Fly   322 CREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALT 386
            ..|::||..:|..|..|.|.|.::......|.|...|..........:||.:||: |:......|
Zfish   306 GGEKKEVDRYDRNLISAQQWGIRKGLIMGFFTGYMWFIIFLCYALAFWYGSSLVV-DTQEYSPGT 369

  Fly   387 AFMLYAGYV--AISMNGLSNFYSQLNKGIGASERIWEILDRECSIP-IDKGVVPLEKPVGEVGFQ 448
            ...::.|.:  |:::...|........|.||:..|:|.:|||..|. :.:....|:|..|::.|.
Zfish   370 LLQVFFGVLIAALNLGQASPCLEAFAAGRGAATIIFETIDREPEIDCLSEAGYKLDKVKGDLEFH 434

  Fly   449 NVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRT 513
            |:.|.:|:|||..:|...:|.:..|.|||.||.||:||:|...|:.|.|||:.|.:.|||.|:|.
Zfish   435 NITFHYPSRPEVKILDQLNLQVKSGETTAFVGPSGAGKSTAIQLIQRFYDPKEGMLTLDGHDIRG 499

  Fly   514 VNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDT 578
            :|.||||:.||.|.||||||:.:|.|||.|| .||  .|.:.:....::||...|...||...:|
Zfish   500 LNIQWLRSLIGIVEQEPVLFATTIAENIRYG-RPG--VSNDDIITAAKEANAYNFIMDLPQKFET 561

  Fly   579 LVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAH 643
            |||:.|..:|||||||:||||||::||.||:||.||||||..||.:||.|||.:..|||.::|||
Zfish   562 LVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKVRMGRTTISIAH 626

  Fly   644 RLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVASQAFGSR 691
            |||||:|||.|.....|:.||:|.::||:. ::||:..||..|:.|.:
Zfish   627 RLSTIKNADVIVGFEHGRAVERGKHDELLE-RKGVYFTLVTLQSQGDK 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	210/623 (34%)
		ABC_membrane	127..395	CDD:279056	69/307 (22%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	121/238 (51%)
abcb11b	XP_003199513.2	ABC_membrane	76..382	CDD:279056	69/310 (22%)
		PTZ00265	157..1339	CDD:240339	196/526 (37%)
		ABC_MTABC3_MDL1_MDL2	432..668	CDD:213216	121/239 (51%)
		ABC_membrane	787..1053	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1105..1344	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900