DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and Abcb10

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	594	Identity:	299/594 - (50%)
Similarity:	422/594 - (71%)	Gaps:	5/594 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVF-NKSGMDSAAMAK 164
            |...|||:..:||.|.:.|:..|:|.:|.|.|||.||||.|.|||::|||:: |.|.....::.:
Mouse   114 PAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRIIDVIYTNPSEGYGDSLTR 178

  Fly   165 LGEYSVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRL 229
            |   ..:|..:|:.|..||..||:|..::...||..||:.|:.|:|.|||.:||...||||||||
Mouse   179 L---CAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFDKTRTGELINRL 240

  Fly   230 SNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRIT 294
            |:||.::|.|:::|:|||||:.|...||.|||.:.||.||.....|||.::.:|::||||:|:::
Mouse   241 SSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLS 305

  Fly   295 KVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFC 359
            |...|..||..:.||||.||::|::.|.:|..||..:.|::|:.||:..||..|||.|||..|..
Mouse   306 KATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKEALARAGFFGAAGLS 370

  Fly   360 GNFIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILD 424
            ||.|::||||.||.|:....:|:|.|::|::||.:|.:|:.|||:|||:|.||:||..|:||:|:
Mouse   371 GNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLE 435

  Fly   425 RECSIPIDKGVVPLEKPV-GEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTT 488
            |:..:|.::|:|..||.. |.:.|:||.||:|.|||.:|..||||::..|:.||:||.|||||:|
Mouse   436 RQPRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKST 500

  Fly   489 IALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSP 553
            :..|:||||||..|||.|||.|:|.:||.|||:.||.|||||||||||:.|||.|||:...:.:.
Mouse   501 VVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTA 565

  Fly   554 ERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALD 618
            :::::..|.||.::|....|.|.||:||::|::||||||||:||||||:|||.||:|||||||||
Mouse   566 QQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALD 630

  Fly   619 AVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELV 683
            |.:|:|||.|||.|::|||||.||||||||:||:.:|||..|||.|.|::.||:....|::|:|:
Mouse   631 AENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLM 695

  Fly   684 ASQAFGSRN 692
            ..|:|.|.|
Mouse   696 NKQSFLSYN 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	293/582 (50%)
		ABC_membrane	127..395	CDD:279056	121/268 (45%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	140/238 (59%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	294/582 (51%)
		ABC_membrane	142..403	CDD:279056	118/263 (45%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	140/239 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848842
Domainoid	1	1.000	233	1.000	Domainoid score	I2398
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6474
Inparanoid	1	1.050	580	1.000	Inparanoid score	I1015
Isobase	1	0.950	-	0	Normalized mean entropy	S1123
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D221577at33208
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	1	1.000	-	-		oto94556
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1969
SonicParanoid	1	1.000	-	-		X2387
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750